9 Best otc acne treatments of 2025

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Best Choice

1

CeraVe
CeraVe Acne Control Gel, 2% Salicylic Acid Treatment With Glycolic Acid + Lactic Acids + Niacniamide, Acne Gel Helps Clear Blemishes Without Over Drying, Alcohol Free & Oil Free, 1.35 Fl Oz

25% Off
Main highlights

Advanced Exfoliation and Hydration
Combines BHA and AHA to clear acne, smooth skin, and maintain moisture.

Ideal for Sensitive and Acne-Prone Skin
Perfect for those seeking gentle yet effective acne treatment.

Unmatched Performance and Affordability
Praised for its effective results and affordable price point.
9.9

Exceptional

Our Rating

8.9
worth the money

8.9
For Gentle skin

8.7
Aroma
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Value for Money

2

Differin
Differin Acne Treatment Gel, 30 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 15g Tube (Packaging May Vary)
Main highlights

Effective Acne Treatment
Differin Gel targets clogged pores and inflammation, reducing breakouts and improving skin texture and tone.

Ideal for Acne-Prone Skin
Best for those with acne-prone, sensitive skin needing a gentle retinoid treatment.

Praised for Clear Skin
Customers love its ability to keep skin clear and smooth, even with hormonal or diet-related acne.
9.7

Exceptional

Our Rating

8.2
worth the money

8.0
Aroma

8.0
Fashion
3

Differin
Differin Acne Spot Treatment with 10% Benzoyl Peroxide, Maximum Strength OTC Acne Treatment, Fast Acting Spot Treatment for Face, 1 oz
Main highlights

Maximum Strength Treatment
Contains 10% benzoyl peroxide for powerful over-the-counter acne treatment.

Fast Acting Solution
Ideal for quick acne relief, visibly reducing size and redness.

Customer Praised Effectiveness
Highly effective at reducing blemishes quickly with minimal application.
9.4

Excellent

Our Rating
4

Neutrogena
Neutrogena On-The-Spot Acne Treatment Gel with Benzoyl Peroxide - Gentle Face Acne Medicine for Acne Prone Skin, 0.75 oz

33% Off
Main highlights

Effective Acne Treatment with Benzoyl Peroxide
.75-ounce tube with 2.5% benzoyl peroxide fights acne gently.

Ideal for Daily Use on Acne-Prone Skin
Use up to three times daily without over-drying.

Praised for Quick and Visible Results
Customers appreciate its effectiveness and quick results.
9.3

Excellent

Our Rating
5

AcneFree
AcneFree Terminator 10 Acne Spot Treatment with Benzoyl Peroxide 10% Maximum Strength Acne Cream Treatment, 1 Ounce - Pack Of 1

35% Off
Main highlights

Maximum Strength Benzoyl Peroxide
Contains 10% benzoyl peroxide for effective acne treatment and redness control.

Ideal for Spot Treatment
Best used for treating individual pimples and mild recurring acne.

Convenient Flip-Cap Design
Praised for its easy-to-use flip-cap that prevents loss and simplifies application.
9.1

Excellent

Our Rating

9.7
quality of ingredients

8.4
worth the money

8.0
Sheerness
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6

Differin
Differin Acne Face Wash with 10% Benzoyl Peroxide, Maximum Strength OTC Acne Foaming Cleanser, Fast Acting Acne Treatment for Face and Body, 5 oz.

21% Off
Main highlights

Maximum Strength Benzoyl Peroxide
Contains 10% benzoyl peroxide for powerful acne treatment.

Versatile Use for Face and Body
Ideal for treating acne on face, chest, and back.

Smooth Skin Results
Customers praise its ability to smooth and clear skin.
9.0

Excellent

Our Rating
7

Neutrogena
Neutrogena Rapid Clear Stubborn Acne Spot Treatment Gel with Maximum Strength 10% Benzoyl Peroxide Acne Treatment Medication, Pimple Cream for Acne Prone Skin Care, 1 oz

27% Off
Main highlights

Maximum Strength Benzoyl Peroxide
Contains 10% benzoyl peroxide for rapid acne reduction.

Ideal for Stubborn Acne
Perfect for treating stubborn acne on acne-prone skin.

Quick and Effective Results
Praised for reducing acne size and redness within hours.
8.8

Very Good

Our Rating

8.7
Aroma

8.4
Fashion

8.2
worth the money
8

Clean & Clear
Clean & Clear, Persa-Gel 10 Acne Spot Treatment, Maximum Strength, 1 Oz

25% Off
Main highlights

Maximum Strength Formula
Contains 10% benzoyl peroxide for effective acne treatment.

Ideal for Spot Treatment
Perfect for inflamed acne bumps and quick results.

Highly Praised for Quick Results
Users report visible reduction in acne overnight.
8.7

Very Good

Our Rating
9

TARO
Taro Adapalene 0.1% Acne Treatment Gel (0.5oz)
Main highlights

Dermatologist Developed Formula
Adapalene 0.1% gel is oil-free, fragrance-free, and paraben-free, designed for acne treatment.

Effective for Acne and Wrinkles
Ideal for daily use to treat acne and improve skin texture.

Highly Effective Yet Potent
Praised for its strong effectiveness; users recommend gradual introduction to avoid irritation.
Key specs
- Function:Acne Treatment
- Usage:Once Daily
- Ingredients:Adapalene 0.1
- Packaging:4.8 x 1.97 x 1.46 inches
- Texture:Gel - Oil Free
8.6

Very Good

Our Rating

9 Best otc acne treatments of 2025

1

CeraVe Acne Control Gel, 2% Salicylic Acid Treatment With Glycolic Acid + Lactic Acids + Niacniamide, Acne Gel Helps Clear Blemishes Without Over Drying, Alcohol Free & Oil Free, 1.35 Fl Oz

8.9

8.9

8.7

How do we rank?

How do we rank?

Analyzing top stores

2

Differin Acne Treatment Gel, 30 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 15g Tube (Packaging May Vary)

8.2

8.0

8.0

3

Differin Acne Spot Treatment with 10% Benzoyl Peroxide, Maximum Strength OTC Acne Treatment, Fast Acting Spot Treatment for Face, 1 oz

4

Neutrogena On-The-Spot Acne Treatment Gel with Benzoyl Peroxide - Gentle Face Acne Medicine for Acne Prone Skin, 0.75 oz

5

AcneFree Terminator 10 Acne Spot Treatment with Benzoyl Peroxide 10% Maximum Strength Acne Cream Treatment, 1 Ounce - Pack Of 1

9.7

8.4

8.0

6

Differin Acne Face Wash with 10% Benzoyl Peroxide, Maximum Strength OTC Acne Foaming Cleanser, Fast Acting Acne Treatment for Face and Body, 5 oz.

7

Neutrogena Rapid Clear Stubborn Acne Spot Treatment Gel with Maximum Strength 10% Benzoyl Peroxide Acne Treatment Medication, Pimple Cream for Acne Prone Skin Care, 1 oz

8.7

8.4

8.2

8

Clean & Clear, Persa-Gel 10 Acne Spot Treatment, Maximum Strength, 1 Oz

9

Taro Adapalene 0.1% Acne Treatment Gel (0.5oz)

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