10 Best oral pain reliefs of 2025

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Best Choice

1

Mommy's Bliss

Mommy's Bliss Little Gums Soothing Oral Tablets, Great for Teething Babies, Benzocaine-Free & Sugar-Free, 2 Months+, 1 Bottle (140 Tablets)
9.9

Exceptional

Our Rating
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Value for Money

2

Mommy's Bliss
Mommy's Bliss Infants' Pain and Fever Reducer, Baby Acetaminophen, Dye Free, Delicious Mixed Berry Flavor, Ages 2+, 2 Fluid Ounces

11% Off
Main highlights

Effective Relief for Infants
Mommys Bliss Infant Acetaminophen reduces fever and relieves minor aches for infants 0-3 years.

Ideal for Cold and Flu
Perfect for treating symptoms like fever, sore throat, and headaches.

Clean Label Certification
Praised for being the first acetaminophen certified by Clean Label Project.
Key specs
- Active Ingredients:Acetaminophen
- Application Method:Syringe
- Duration of Relief:Temporary
- Formulation:Liquid
- Target Area:General
9.8

Exceptional

Our Rating
3

Safetec

Safetec Oral Pain Relief, .75 g Packets, Box of 144
9.6

Exceptional

Our Rating
4

Orajel
Orajel 2X Medicated Toothache & Mouth Sores Liquid, 0.45 Fl Oz
Main highlights

Fast-Acting Pain Relief
Contains 20% Benzocaine and menthol for quick oral pain relief.

Ideal for Toothaches and Mouth Sores
Perfect for pre-dental visits and immediate relief from toothaches.

Customer Praised for Quick Action
Users appreciate its fast-acting formula and effective pain coverage.
9.5

Excellent

Our Rating

9.7
pain management

8.7
Simple to use

8.0
Flavor
5

Orajel
Orajel 4X for Toothache & Gum Pain: Severe Cream Tube 0.33oz- From Oral Pain Relief Brand

25% Off
Main highlights

Instant Pain Relief Formula
Orajel's 4X clinical strength formula provides fast relief for tooth and gum pain.

Ideal for Pre-Dental Visits
Useful for managing pain before seeing a dentist, offering temporary relief.

Praised for Immediate Relief
Customers appreciate the immediate pain relief, though it may wear off quickly.
9.4

Excellent

Our Rating

9.5
pain management

8.9
worth the money

8.0
Flavor
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6

DenTek
DenTek Instant Oral Pain Relief Maximum Strength Kit for Toothaches | 50 Count

19% Off
Main highlights

Instant Pain Relief
DenTek kit provides immediate relief from oral pain and toothaches.

Ideal for Sensitive Teeth
Perfect for temporary relief of sensitive teeth and sore gums.

Praised Applicator Design
Customers love the easy-to-use applicators for precise application.
9.3

Excellent

Our Rating

9.5
Simple to use

8.9
worth the money

8.9
pain management
7

Orajel
Orajel 3X for Toothache & Gum Pain: Maximum Gel Tube 0.42oz - From #1 Oral Pain Relief Brand - Orajel for Instant Pain Relief
Main highlights

Instant Pain Relief with Maximum Strength Formula
Orajel provides immediate pain relief for tooth and gum discomfort with its maximum strength formula containing 20% benzocaine.

Emergency Dental Pain Relief
Ideal for providing temporary relief from toothaches, gum irritation, and pain from dental aligners, helping avoid emergency dental visits.

Fast-Acting and Effective
Customers frequently praise Orajel for its quick pain relief and effectiveness, although some mention the need for frequent reapplication and issues with the tube design.
9.1

Excellent

Our Rating

9.5
pain management

9.1
Long life

8.7
Simple to use
8

Rite Aid
Rite Aid Maximum Strength Liquid Anesthetic Oral Pain Relief - .5 fl oz, Benzocaine 20% | Pain Relief Medications & Treatments | Canker Sore and Tooth Pain Relief for Adults | Mouth Sores Treatment
Main highlights

Key Features and Benefits
Fast-acting, maximum strength Benzocaine 20% formula provides instant pain relief for toothaches, sore gums, and mouth sores.

Ideal Use Cases
Perfect for relieving pain from toothaches, canker sores, dentures/braces discomfort, minor dental procedures, and injuries from cheek bites.

Customer Reviews Highlight
Users highly praise its quick pain relief for mouth and gum issues, comparing it favorably to leading brands for effectiveness.
9.0

Excellent

Our Rating
9

Hyland's
Hyland's Baby Daytime Soothing Tablets with Chamomilla, Natural Relief of Oral Discomfort, Irritability, and Swelling, (Pack of 1, 125 Count Total)

25% Off
Main highlights

Relief of Oral Discomfort
Naturally relieves symptoms of oral discomfort including sore, sensitive, or swelling gums and irritability. Made with natural active ingredients, no artificial flavors or sugars.

Ideal for Teething Babies
Best for babies experiencing teething discomfort. Quick-dissolving tablets melt in the mouth instantly, providing fast relief. Suitable for daytime and nighttime use.

Quick Dissolving and Effective
Customers praise the fast-dissolving tablets that provide quick relief from teething pain. Easy to administer and well-tolerated by babies, making it a parent favorite.
8.9

Very Good

Our Rating

9.9
pain management

9.9
Simple to use

9.3
Flavor
10

Anbesol
Anbesol Maximum Strength Oral Pain Relief Gel, Instant Pain Relief For Toothache Pain, Canker Sores, Sore Gums, Mouth Sores, Denture Pain, and Aligner Pain, ADA Accepted, 0.33 oz (packaging may vary)
Main highlights

Instant Oral Pain Relief
Formulated with Benzocaine for fast, temporary relief from mouth pain.

Ideal for Various Oral Pains
Effective for toothaches, canker sores, sore gums, and more.

Praised for Quick Numbing
Customers appreciate its immediate numbing effect for pain relief.
8.8

Very Good

Our Rating

8.9
worth the money

8.4
pain management

8.0
Flavor

10 Best oral pain reliefs of 2025

1

Mommy's Bliss Little Gums Soothing Oral Tablets, Great for Teething Babies, Benzocaine-Free & Sugar-Free, 2 Months+, 1 Bottle (140 Tablets)

How do we rank?

How do we rank?

Analyzing top stores

2

Mommy's Bliss Infants' Pain and Fever Reducer, Baby Acetaminophen, Dye Free, Delicious Mixed Berry Flavor, Ages 2+, 2 Fluid Ounces

3

Safetec Oral Pain Relief, .75 g Packets, Box of 144

4

Orajel 2X Medicated Toothache & Mouth Sores Liquid, 0.45 Fl Oz

9.7

8.7

8.0

5

Orajel 4X for Toothache & Gum Pain: Severe Cream Tube 0.33oz- From Oral Pain Relief Brand

9.5

8.9

8.0

6

DenTek Instant Oral Pain Relief Maximum Strength Kit for Toothaches | 50 Count

9.5

8.9

8.9

7

Orajel 3X for Toothache & Gum Pain: Maximum Gel Tube 0.42oz - From #1 Oral Pain Relief Brand - Orajel for Instant Pain Relief

9.5

9.1

8.7

8

Rite Aid Maximum Strength Liquid Anesthetic Oral Pain Relief - .5 fl oz, Benzocaine 20% | Pain Relief Medications & Treatments | Canker Sore and Tooth Pain Relief for Adults | Mouth Sores Treatment

9

Hyland's Baby Daytime Soothing Tablets with Chamomilla, Natural Relief of Oral Discomfort, Irritability, and Swelling, (Pack of 1, 125 Count Total)

9.9

9.9

9.3

10

Anbesol Maximum Strength Oral Pain Relief Gel, Instant Pain Relief For Toothache Pain, Canker Sores, Sore Gums, Mouth Sores, Denture Pain, and Aligner Pain, ADA Accepted, 0.33 oz (packaging may vary)

8.9

8.4

8.0

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Orajel 3X for Mouth Sores: Maximum Strength Gel Tube 0.42oz- From #1 Oral Pain Relief Brand

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