10 Best mthfr supplements of 2025

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1

PD VARS
Physician Designed MTHFR Daily Multivitamin | Methylated Multivitamin for Men & Women | for Energy, Mood, & Heart | Vitamin B-Complex | 120 Capsules
Main highlights

Error Pathway Correction and Energy Boost
Provides error pathways correction, improved energy and mood, methylation, homocysteine and cardiovascular health. Pure pharmaceutical grade encapsulation for optimum use by the body.

Support for MTHFR Genetic Errors
Formulated to provide support for MTHFR genetic errors utilizing intracellular vitamin and amino acid deficiencies. Ideal for folate deficiency and overall wellness.

Improved Energy and Mood
Customers frequently praise the product for boosting energy levels and enhancing mood, especially beneficial for those with genetic issues or conditions like PCOS.
9.9

Exceptional

Our Rating

9.9
simple to consume

9.3
Efficient Energy Use

8.0
quality of ingredients
How do we rank?

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Value for Money

2

10X Health System
10X Health 5 MTHF Supplement - Methylated Multivitamin with Methylfolate & Magnesium for Brain, Heart Health, DNA & Neurotransmitter Synthesis - Bioavailable 5-MTHF Supplement - 60 Capsules
Main highlights

Enhanced Absorption and Health Benefits
Boosted bioavailability with 5-MTHF for better absorption, supporting brain, heart, and DNA health.

Ideal for Cognitive and Mood Support
Perfect for those seeking improved neurotransmitter production and mood stability.

Consistently High-Quality Ingredients
Customers praise the consistent quality and secure packaging of the capsules.
Key specs
- Form:Capsules
- Active Ingredient:5-MTHF
- Bioavailability:Boosted
- Dosage:N/A
- GMP Certified:N/A
9.8

Exceptional

Our Rating
3

Triquetra Health
L Methyl Folate 15mg Plus Methyl B12 Cofactor – Organic Berry Flavor, High Potency Liquid Sublingual Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive Forms Vitamin B9 & B12 (1oz)
Main highlights

Key Features and Benefits
Clinically validated 15mg L-Methylfolate in active form for superior absorption, with essential Methyl B12 for methylation and homocysteine breakdown.

Ideal Use Cases
Ideal for supporting brain, mood, energy, cardiovascular health, and nerve function, especially in those with methylation issues who can`t process folic acid.

Customer Reviews Summary
Highly praised for its effective support of mood and energy levels, with the cherry-flavored, sublingual form noted for its ease of use.
Key specs
- Form:Liquid sublingual
- Active Ingredient:L Methyl folate
- Bioavailability:Enhanced sublingual absorption
- Dosage:15mg
- GMP Certified:N/A
9.7

Exceptional

Our Rating

9.7
simple to consume

9.7
Absorbency

9.5
worth the money
4

THORNE
THORNE 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation, and Homocysteine Levels* - 60 Capsules - 5-MTHF 1mg
Main highlights

Supports Cardiovascular and Nerve Health
Thorne 5-MTHF provides active folate for cardiovascular, nerve health, and methylation support.

Ideal for MTHFR Gene Mutation
Perfect for individuals with MTHFR mutation needing enhanced folate absorption.

Improves Focus and Mood
Customers praise its ability to enhance focus, mood, and overall well-being.
9.6

Exceptional

Our Rating

9.9
simple to consume

9.5
Absorbency

9.3
worth the money
5

Igennus Healthcare Nutrition
Igennus Super B-Complex Methylated B Vitamins, Sustained Release, Clean Label, MTHFR Supplement with Methylfolate & B12 Methylcobalamin, Vegan, Lab Verified, 60 Small Tablets
Main highlights

High Absorption B Vitamins
Features methylated forms like methylfolate & methylcobalamin for superior absorption and efficacy.

Ideal for Energy and Heart Health
Supports energy metabolism, immune function, and heart health with MTHFR-friendly ingredients.

Praised for Clean Ingredients
Customers appreciate the absence of fillers and the vegan, hypoallergenic formula.
9.5

Excellent

Our Rating

9.7
simple to consume

9.7
quality of ingredients

9.5
worth the money
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6

Triquetra Health
Organic Methyl Folate 1000 mcg + Methyl B12 Cofactor (300 Servings) – Metabolically Active 5-MTHF Form, Organic Berry Flavor, Liquid Sublingual Form – Mood, Cognition, Methylation, Pregnancy (1oz)
Main highlights

Biologically Active Folate
L-Methylfolate in 1000 mcg dose for immediate absorption and no processing.

Ideal for Methylation Support
Supports healthy methylation, brain, mood, energy, and pregnancy needs.

Easy Sublingual Use
Praised for its pleasant taste and straightforward sublingual application.
Key specs
- Form:Liquid sublingual
- Active Ingredient:L-Methylfolate
- Bioavailability:Enhanced sublingual absorption
- Dosage:1 mg or 1000 mcg
- GMP Certified:N/A
9.3

Excellent

Our Rating
7

Triquetra Health

Organic Kids Methylfolate + Methyl B12 Cofactor - Organic Berry Flavor, Sublingual Form - 5-MTHF Form, Superior Form of Folate - Adjustable Dosing for All Ages - Mood, Behavior, Cognition - 1 oz.
9.1

Excellent

Our Rating
8

Jarrow Formulas
Jarrow Formulas Methyl B-12 1000 MCG and Methyl Folate 400 MCG, Extra Strength, Cellular Energy Metabolism and Cardiovascular Health Formula(1) With P-5-P, 100 Chewable Tablets, Up to a 100 Day Supply

39% Off
Main highlights

Key Features
Combines Methyl B12, Methyl Folate, and P-5-P for enhanced energy metabolism, cardiovascular support, and neurotransmitter synthesis in lemon-flavored chewables.

Ideal Use Cases
Perfect for adults seeking to boost energy, support heart health, and improve neurological function with a daily, easy-to-take supplement.

Customer Reviews Highlight
Most praised for its noticeable boost in energy levels and overall mood improvement, according to consistent user feedback.
Key specs
- Target:Cellular energy metabolism
- Form:Chewable Tablets
- Dosage:1000 mcg
- Quantity:100 count
- Flavor:Lemon
9.0

Excellent

Our Rating

9.3
simple to consume

9.3
worth the money

9.3
Absorbency
9

Seeking Health
Seeking Health Methyl B12 with L-Methylfolate - MTHFR Support Supplement - Methylation Support Supplement - Lozenges to Support Brain Health & Energy - 60 Lozenges
Main highlights

Energy and Brain Health Support
Provides active forms of B12 and folate for energy and cognitive health.

Ideal for MTHFR Gene Mutation
Supports methylation pathways, beneficial for those with MTHFR gene mutation.

Tasty and Convenient Lozenge
Praised for its pleasant taste and ease of use.
Key specs
- Target:Energy, Mood, Focus
- Form:Lozenge
- Dosage:1,360 mcg DFE
- Quantity:N/A
- Flavor:N/A
8.9

Very Good

Our Rating

9.9
simple to consume

9.9
Flavor

9.7
Absorbency
10

Triquetra Health
L Methylfolate 7.5mg plus Methyl B12 - Active 5-MTHF Form, MTHFR Supplement - Bloodstream Ready Methylated Folate + B12 Cofactor - Supports Mood, Homocysteine Methylation, Cognition (60 Capsules)
Main highlights

Bioavailable Active Folate and B12
Contains 7.5mg L-Methylfolate and Methyl B12 for optimal absorption and metabolism.

Ideal for Methylation Support
Perfect for those with methylation issues needing active folate and B12.

Customer Praises for Energy Boost
Users report significant improvements in energy and mood after use.
Key specs
- Form:Capsule
- Active Ingredient:L Methylfolate 7.5mg
- Bioavailability:Immediate absorption
- Dosage:7.5mg
- GMP Certified:Yes
8.6

Very Good

Our Rating

10 Best mthfr supplements of 2025

1

Physician Designed MTHFR Daily Multivitamin | Methylated Multivitamin for Men & Women | for Energy, Mood, & Heart | Vitamin B-Complex | 120 Capsules

9.9

9.3

8.0

How do we rank?

How do we rank?

Analyzing top stores

2

10X Health 5 MTHF Supplement - Methylated Multivitamin with Methylfolate & Magnesium for Brain, Heart Health, DNA & Neurotransmitter Synthesis - Bioavailable 5-MTHF Supplement - 60 Capsules

3

L Methyl Folate 15mg Plus Methyl B12 Cofactor – Organic Berry Flavor, High Potency Liquid Sublingual Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive Forms Vitamin B9 & B12 (1oz)

9.7

9.7

9.5

4

THORNE 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation, and Homocysteine Levels* - 60 Capsules - 5-MTHF 1mg

9.9

9.5

9.3

5

Igennus Super B-Complex Methylated B Vitamins, Sustained Release, Clean Label, MTHFR Supplement with Methylfolate & B12 Methylcobalamin, Vegan, Lab Verified, 60 Small Tablets

9.7

9.7

9.5

6

Organic Methyl Folate 1000 mcg + Methyl B12 Cofactor (300 Servings) – Metabolically Active 5-MTHF Form, Organic Berry Flavor, Liquid Sublingual Form – Mood, Cognition, Methylation, Pregnancy (1oz)

7

Organic Kids Methylfolate + Methyl B12 Cofactor - Organic Berry Flavor, Sublingual Form - 5-MTHF Form, Superior Form of Folate - Adjustable Dosing for All Ages - Mood, Behavior, Cognition - 1 oz.

8

Jarrow Formulas Methyl B-12 1000 MCG and Methyl Folate 400 MCG, Extra Strength, Cellular Energy Metabolism and Cardiovascular Health Formula(1) With P-5-P, 100 Chewable Tablets, Up to a 100 Day Supply

9.3

9.3

9.3

9

Seeking Health Methyl B12 with L-Methylfolate - MTHFR Support Supplement - Methylation Support Supplement - Lozenges to Support Brain Health & Energy - 60 Lozenges

9.9

9.9

9.7

10

L Methylfolate 7.5mg plus Methyl B12 - Active 5-MTHF Form, MTHFR Supplement - Bloodstream Ready Methylated Folate + B12 Cofactor - Supports Mood, Homocysteine Methylation, Cognition (60 Capsules)

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