10 Best mitochondrial supplements of 2025

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Best Choice

1

Designs for Health
Designs for Health Mitochondrial NRG - Support Cellular Vitality + Metabolism - Mitochondria Energy Supplement with Alpha Lipoic Acid, Trans Resveratrol + Curcumin Powder (120 Vegan Capsules)
Main highlights

Energy and Metabolism Support
Features active B vitamins, CoQ10, and ALA for energy and mitochondrial health.

Ideal for Fatigue and Performance
Perfect for those with fatigue or seeking improved athletic performance.

Praised for Quick Effectiveness
Customers appreciate the fast-acting and noticeable energy boost.
9.9

Exceptional

Our Rating

9.9
Absorbency

9.9
quality of ingredients

9.9
Flavor
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Value for Money

2

MitoQ
MitoQ Pure Mitochondria-targeted Antioxidant Supplement | Reducing Free Radical Damage & Oxidative Stress | Supports Cellular Longevity, Metabolic Health, Healthier Aging, and Energy (60 Capsules)
Main highlights

Targeted Antioxidant Support
Delivers CoQ10 directly to mitochondria for enhanced energy and organ health.

Ideal for Aging and Energy
Perfect for aging individuals seeking improved vitality and organ performance.

Praised for Muscle Pain Relief
Customers report significant relief from muscle pain associated with statin use.
9.7

Exceptional

Our Rating

9.5
simple to consume

8.9
Absorbency

8.0
worth the money
3

Resciency
2326 MG Mitochondrial Supplements with ATP, Vitamins, CoQ10 & PQQ, More Effective Than Creatine HMB & Nitric Oxide, Energy, Endurance, Strength, Recovery & Muscle, Organic, 240 Capsules
Main highlights

Comprehensive Energy Support
Combines ATP, CoQ10, PQQ, and vitamins for enhanced energy, endurance, and recovery.

Ideal for Active Lifestyles
Perfect for fitness enthusiasts and busy individuals needing sustained energy and muscle support.

Praised for Organic Ingredients
Customers love the natural energy boost from organic beetroot and maca root.
9.5

Excellent

Our Rating
4

Life Extension
Life Extension Mitochondrial Energy Optimizer with PQQ – For Heart & Brain Health, Energy Management and Anti-Aging - Gluten-Free, Non-GMO, Vegetarian – 120 Capsules

25% Off
Main highlights

Cellular Energy Boost
Combines PQQ, carnosine, R-lipoic acid to enhance energy.

Ideal for Energy Management
Perfect for those seeking improved mental and physical energy.

Customer Praised Energy Boost
Highly effective in increasing energy levels throughout the day.
9.4

Excellent

Our Rating

8.9
simple to consume

8.9
Flavor

8.7
worth the money
5

Peak Performance
Mitochondria Maximizer with CoQ10 and Active PQQ. Best Mitochondrial Support Supplement with MCT Oil. Natural Cellular Generator for Clean, Focused Energy 60 Vegetarian Capsules
Main highlights

Enhanced Cellular Energy
Peak Performance supplement supports mitochondrial function with PQQ and CoQ10, improving energy production and absorption.

Ideal for Chronic Pain Relief
Beneficial for those with joint inflammation or arthritis seeking reduced pain and increased mobility.

Boosts Mental Clarity
Customers praise improved alertness and focus, ideal for demanding work environments.
9.1

Excellent

Our Rating

9.9
worth the money

9.7
simple to consume

9.5
Absorbency
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6

CystoRebalance
CystoRebalance Urolithin A Supplement 2000MG - for Healthy Aging, Antioxidants and Mitochondrial Support - High Purity & Potency - 120 Softgels - 2 Month Supply
Main highlights

High Absorption and Potency
2000 mg of Urolithin A in easy-to-swallow softgels for enhanced absorption and effectiveness.

Ideal for Healthy Aging
Promotes overall wellness and mitochondrial support, perfect for those seeking antioxidants and longevity benefits.

Customer Praise for Convenience
Users love the convenient softgel form and the easy daily dosage.
8.8

Very Good

Our Rating
7

NUTRAHARMONY
PQQ 40 mg - PQQ with CoQ10 Supplement - Mitochondria Biogenesis & Cellular Energy Production - with Magnesium, Vitamins C, E & B2 - Pure & Highly Bioavailable | Lab Tested - Made in USA - 60 Capsules
Main highlights

Energy and Cognitive Support
PQQ 40mg capsules enhance energy, cellular health, and cognitive function for optimal vitality and mental clarity.

Ideal for Active Lifestyles
Perfect for those seeking enhanced endurance, stamina, and brain health without caffeine.

Smooth and Easy to Swallow
Users praise the pill's easy consumption and lack of aftertaste.
8.7

Very Good

Our Rating
8

Artnaturals
NAD Supplement 8457 mg Extra Strength NMN Alternative Liposomal + Green Tea for Women & Men w/Urolithin A, Resveratrol, CoQ10, Alpha Lipoic Acid – Energy Anti-Aging,Cell Regeneration –30-Day
Main highlights

NAD+ Urolithin A Complex Benefits
Harnesses a unique NAD+ formula with Urolithin A for cellular energy and vitality.

Optimal Use for Energy and Longevity
Ideal for enhancing energy, promoting longevity, and supporting overall wellness.

Customer Praise for Absorption and Effectiveness
Praised for superior absorption and noticeable effectiveness in boosting energy.
8.6

Very Good

Our Rating
9

Life Extension
Life Extension PQQ Caps – Pyrroloquinoline Quinone, 10 mg – Promotes The Growth of New Mitochondria, ATP, Energy Support – Gluten-Free, Non-GMO, Vegetarian – 30 Capsules

50% Off
Main highlights

Promotes Mitochondrial Growth
PQQ supports new mitochondrial growth, boosting cellular energy.

Ideal for Aging Adults
Useful for older individuals needing cognitive and energy support.

Praised for Energy Boost
Customers report increased energy and reduced fatigue.
8.3

Good

Our Rating

9.9
quality of ingredients

9.3
Efficient Energy Use

8.0
worth the money
10

Life Extension
Life Extension Mitochondrial Basics with PQQ, L-Taurine, R-lipoic Acid, foundational Supplement for Cellular Energy Production, Brain and Heart Health, Gluten-Free, Non-GMO, Vegetarian, 30 Capsules

15% Off
Main highlights

Supports Cellular Energy Production
Contains PQQ, R-lipoic acid, and taurine to enhance energy.

Ideal for Mitochondrial Support
Best for those with mitochondrial-related energy issues.

Praised for Overall Well-Being
Users report improved mental clarity and presence.
8.2

Good

Our Rating

10 Best mitochondrial supplements of 2025

1

Designs for Health Mitochondrial NRG - Support Cellular Vitality + Metabolism - Mitochondria Energy Supplement with Alpha Lipoic Acid, Trans Resveratrol + Curcumin Powder (120 Vegan Capsules)

9.9

9.9

9.9

2

MitoQ Pure Mitochondria-targeted Antioxidant Supplement | Reducing Free Radical Damage & Oxidative Stress | Supports Cellular Longevity, Metabolic Health, Healthier Aging, and Energy (60 Capsules)

9.5

8.9

8.0

3

2326 MG Mitochondrial Supplements with ATP, Vitamins, CoQ10 & PQQ, More Effective Than Creatine HMB & Nitric Oxide, Energy, Endurance, Strength, Recovery & Muscle, Organic, 240 Capsules

4

Life Extension Mitochondrial Energy Optimizer with PQQ – For Heart & Brain Health, Energy Management and Anti-Aging - Gluten-Free, Non-GMO, Vegetarian – 120 Capsules

8.9

8.9

8.7

5

Mitochondria Maximizer with CoQ10 and Active PQQ. Best Mitochondrial Support Supplement with MCT Oil. Natural Cellular Generator for Clean, Focused Energy 60 Vegetarian Capsules

9.9

9.7

9.5

6

CystoRebalance Urolithin A Supplement 2000MG - for Healthy Aging, Antioxidants and Mitochondrial Support - High Purity & Potency - 120 Softgels - 2 Month Supply

7

PQQ 40 mg - PQQ with CoQ10 Supplement - Mitochondria Biogenesis & Cellular Energy Production - with Magnesium, Vitamins C, E & B2 - Pure & Highly Bioavailable | Lab Tested - Made in USA - 60 Capsules

8

NAD Supplement 8457 mg Extra Strength NMN Alternative Liposomal + Green Tea for Women & Men w/Urolithin A, Resveratrol, CoQ10, Alpha Lipoic Acid – Energy Anti-Aging,Cell Regeneration –30-Day

9

Life Extension PQQ Caps – Pyrroloquinoline Quinone, 10 mg – Promotes The Growth of New Mitochondria, ATP, Energy Support – Gluten-Free, Non-GMO, Vegetarian – 30 Capsules

9.9

9.3

8.0

10

Life Extension Mitochondrial Basics with PQQ, L-Taurine, R-lipoic Acid, foundational Supplement for Cellular Energy Production, Brain and Heart Health, Gluten-Free, Non-GMO, Vegetarian, 30 Capsules

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