10 Best methylfolates of 2025

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Best Choice

1

Carlyle
Carlyle L Methylfolate 15mg | 120 Capsules | Value Size | Max Potency | Optimized and Activated | Non-GMO, Gluten Free | Methyl Folate, 5-MTHF | by Opti-Folate

14% Off
Main highlights

High Potency Formula
Delivers 25,000 mcg Folate and 15 mg L-Methylfolate for maximum efficacy.

Ideal for Genetic Conditions
Perfect for individuals with genetic conditions affecting folate metabolism.

Praised for Affordability
Customers appreciate the cost-effectiveness compared to prescription alternatives.
9.6

Exceptional

Our Rating

9.9
simple to consume

9.9
Absorbency

9.5
worth the money
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Shoppers influence our rankings
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Value for Money

2

THORNE
THORNE 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation, and Homocysteine Levels* - 60 Capsules - 5-MTHF 1mg
Main highlights

Supports Cardiovascular and Nerve Health
Thorne 5-MTHF provides active folate for cardiovascular, nerve health, and methylation support.

Ideal for MTHFR Gene Mutation
Perfect for individuals with MTHFR mutation needing enhanced folate absorption.

Improves Focus and Mood
Customers praise its ability to enhance focus, mood, and overall well-being.
9.5

Excellent

Our Rating

9.9
simple to consume

9.5
Absorbency

9.3
worth the money
3

Triquetra Health
L Methyl Folate 15mg Plus Methyl B12 Cofactor – Organic Berry Flavor, High Potency Liquid Sublingual Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive Forms Vitamin B9 & B12 (1oz)
Main highlights

Key Features and Benefits
Clinically validated 15mg L-Methylfolate in active form for superior absorption, with essential Methyl B12 for methylation and homocysteine breakdown.

Ideal Use Cases
Ideal for supporting brain, mood, energy, cardiovascular health, and nerve function, especially in those with methylation issues who can`t process folic acid.

Customer Reviews Summary
Highly praised for its effective support of mood and energy levels, with the cherry-flavored, sublingual form noted for its ease of use.
9.4

Excellent

Our Rating

9.7
simple to consume

9.7
Absorbency

9.5
worth the money
4

NOW Foods
NOW Foods Supplements, Methyl Folate 1,000 mcg, Metabolically Active Folate*, Co-Enzyme B Vitamin, 90 Tablets

38% Off
Main highlights

Superior Bioavailability and Potency
Methylfolate, a biologically active form, enhances cell function and DNA synthesis.

Ideal for MTHFR Gene Mutation
Perfect for those needing methylfolate supplementation due to genetic mutations.

Easy to Swallow Tablets
Customers appreciate the ease of swallowing despite the tablet size.
9.1

Excellent

Our Rating

9.9
simple to consume

9.9
Absorbency

9.7
worth the money
5

Triquetra Health
Organic Methyl Folate 1000 mcg + Methyl B12 Cofactor (300 Servings) – Metabolically Active 5-MTHF Form, Organic Berry Flavor, Liquid Sublingual Form – Mood, Cognition, Methylation, Pregnancy (1oz)
Main highlights

Biologically Active Folate
L-Methylfolate in 1000 mcg dose for immediate absorption and no processing.

Ideal for Methylation Support
Supports healthy methylation, brain, mood, energy, and pregnancy needs.

Easy Sublingual Use
Praised for its pleasant taste and straightforward sublingual application.
8.9

Very Good

Our Rating
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6

Life Extension
Life Extension Optimized Folate – L-methylfolate – Heart & Brain Support, Healthy Homocysteine Levels – Non-GMO, Gluten-Free, Vegetarian – 1700 mcg DFE, 100 Vegetarian Tablets

16% Off
Main highlights

Optimal Cognitive Support
This folate supplement supports brain health and optimal cognitive function as you age.

Ideal for MTHFR Mutation
Best for individuals with MTHFR mutation needing L-methylfolate supplementation.

Highly Effective Methylfolate
Praised for its high-quality, effective L-methylfolate form over folic acid.
8.8

Very Good

Our Rating

9.3
simple to consume

9.3
worth the money

9.1
Flavor
7

Nutricost
Nutricost Methylfolate 1000mcg, 120 Vegetarian Capsules - Gluten Free, Non-GMO

18% Off
Main highlights

High Potency Formula
Contains 1,000mcg Methyl Folate per serving; 120 servings total.

Ideal for Energy Boost
Perfect for individuals seeking enhanced energy and mood improvement.

Praised for Value
Customers frequently commend its affordability and noticeable benefits.
8.7

Very Good

Our Rating

9.5
simple to consume

9.5
Flavor

9.1
Absorbency
8

Jarrow Formulas
Jarrow Formulas Extra Strength Methyl Folate 400 mcg, Dietary Supplement for Cardiovascular and Neurologic Health Support, 60 Veggie Capsules, 60 Day Supply

25% Off
Main highlights

Supports Cardiovascular and Neurologic Health
Contains 400 mcg of Methyl Folate 5-MTHF for heart and brain support.

Ideal for MTHFR Gene Mutation
Perfect for individuals who cannot convert synthetic folic acid.

High Bioavailability and Quality
Praised for its bioavailable form, Quatrefolic methyl folate.
8.6

Very Good

Our Rating

9.9
simple to consume

9.7
quality of ingredients

9.7
Absorbency
9

Double Wood Supplements
Methylfolate 1,000mcg, 120 Capsules (Third Party Tested Methyl Folate Supplement) Methylated Folate is a More Active Form of Folate Than Folic Acid (Non-GMO, Vegan Safe) by Double Wood
Main highlights

Bioavailable Folate
L Methyl Folate is the active form of folate, easily absorbed into the bloodstream.

Energy Support
Ideal for individuals seeking to enhance energy levels and combat fatigue.

High Quality
Praised for noticeable improvements in muscle energy consumption.
8.5

Good

Our Rating
10

365 by Whole Foods Market

365 by Whole Foods Market, Methyl Folate, 100 Count
8.3

Good

Our Rating

10 Best methylfolates of 2025

1

Carlyle L Methylfolate 15mg | 120 Capsules | Value Size | Max Potency | Optimized and Activated | Non-GMO, Gluten Free | Methyl Folate, 5-MTHF | by Opti-Folate

9.9

9.9

9.5

How do we rank?

How do we rank?

Analyzing top stores

2

THORNE 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation, and Homocysteine Levels* - 60 Capsules - 5-MTHF 1mg

9.9

9.5

9.3

3

L Methyl Folate 15mg Plus Methyl B12 Cofactor – Organic Berry Flavor, High Potency Liquid Sublingual Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive Forms Vitamin B9 & B12 (1oz)

9.7

9.7

9.5

4

NOW Foods Supplements, Methyl Folate 1,000 mcg, Metabolically Active Folate*, Co-Enzyme B Vitamin, 90 Tablets

9.9

9.9

9.7

5

Organic Methyl Folate 1000 mcg + Methyl B12 Cofactor (300 Servings) – Metabolically Active 5-MTHF Form, Organic Berry Flavor, Liquid Sublingual Form – Mood, Cognition, Methylation, Pregnancy (1oz)

6

Life Extension Optimized Folate – L-methylfolate – Heart & Brain Support, Healthy Homocysteine Levels – Non-GMO, Gluten-Free, Vegetarian – 1700 mcg DFE, 100 Vegetarian Tablets

9.3

9.3

9.1

7

Nutricost Methylfolate 1000mcg, 120 Vegetarian Capsules - Gluten Free, Non-GMO

9.5

9.5

9.1

8

Jarrow Formulas Extra Strength Methyl Folate 400 mcg, Dietary Supplement for Cardiovascular and Neurologic Health Support, 60 Veggie Capsules, 60 Day Supply

9.9

9.7

9.7

9

Methylfolate 1,000mcg, 120 Capsules (Third Party Tested Methyl Folate Supplement) Methylated Folate is a More Active Form of Folate Than Folic Acid (Non-GMO, Vegan Safe) by Double Wood

10

365 by Whole Foods Market, Methyl Folate, 100 Count

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