10 Best methylated multivitamins of 2025

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10X Health System
10X Health Optimize Methylated Multivitamin for Men & Women - 34 in 1 Formula with 800 mcg of Vitamin B12, Vitamin E, 5-MTHF, B Complex, NAC, Magnesium & Zinc Multivitamins - 90 Capsules
Main highlights

Comprehensive Nutritional Support
10x Optimize provides a multivitamin and mineral formula addressing genetic methylation deficits for optimal health.

Efficient Supplementation
Best used for reducing overall supplement intake while maintaining nutritional balance.

Enhanced Absorption and Well-being
Praised for methylated nutrients improving absorption, reducing anxiety, and boosting sleep quality.
9.6

Exceptional

Our Rating
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Value for Money

2

Pure Therapro Rx
Methyl Multi Without Iron Methylated Multivitamin for Men & Women, 120-Day Supply | Methyl B12 & Methylfolate (5-MTHF) for MTHFR Support | Pharma Grade Multivitamin & Multimineral For Health, 240 Caps
Main highlights

Comprehensive Wellness Support
Methyl Multi without Iron is a meticulously-researched multivitamin promoting cognitive function and detoxification with high-quality ingredients.

Ideal for MTHFR Mutations
Perfect for individuals with MTHFR mutations, enhancing vitamin absorption and supporting metabolism and energy release.

Customer-Praised Effectiveness
Customers appreciate the improvement in B12 levels and reduced neuropathic symptoms, highlighting its effectiveness.
9.5

Excellent

Our Rating

9.9
quality of ingredients

9.5
worth the money

9.5
Absorbency
3

NUTRAHARMONY
Methylated Multivitamin - B-Complex with Methylfolate & B12 - for Men & Women - 9-in-1 MTHFR Supplement with TMG - for Energy, Brain & Mood - Vegan, Lab Tested - Made in USA - 120 Capsules, One/Day
Main highlights

Essential Vitamins for Methylation
Contains 9 vital vitamins including methylated B complex for daily wellness.

Daily Energy and Cognitive Support
Ideal for boosting energy, enhancing focus, and maintaining mood balance.

Customer Favorite for Energy Boost
Praised for its effective energy and metabolism support.
9.4

Excellent

Our Rating
4

Micro Ingredients
Pure Methylated Multivitamin for Men & Women | 240 Capsules with Vitamins C, D, B12, Thiamin, Folate + Magnesium, Zinc, & More | High Absorption | Bioactive Vitamin & Mineral Complex | Filler Free
Main highlights

High Absorption Bioactive Form
This multivitamin features 19 essential nutrients in highly absorbable forms, ensuring effective nutrient uptake and utilization.

Comprehensive Health Support
Ideal for men and women seeking energy, heart, immune, and brain health support through a complete multivitamin solution.

Filler-Free Formula
Customers appreciate the pure, active ingredients without fillers, enhancing the supplement's effectiveness and safety.
9.2

Excellent

Our Rating
5

Double Wood Supplements
Methylated Multivitamin (Methylated and Activated Vitamins Only - B Complex with Trimethylglycine (TMG) and Methylfolate)(Non-GMO, Gluten Free MTHFR Supplement) 120 Capsules by Double Wood
Main highlights

Methylated and Activated Vitamins
Contains methylated forms of vitamins for improved bioavailability and absorption.

Ideal for MTHFR Gene Mutation
Perfect for individuals needing methylated vitamins due to MTHFR mutation.

Praised for Bioavailability
Customers appreciate the bioavailability of pre-converted B vitamins.
9.1

Excellent

Our Rating
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6

Igennus Healthcare Nutrition
Igennus Methylated Men's Multivitamin, MTHFR Supplement with Active B-Vitamins, 21 Highly Bioavailable Nutrients, Multivitamin for Sustained Release, Clean Label, Non-GMO & Halal 60 Tablets

21% Off
Main highlights

High-Potency Nutrients
22 essential nutrients with bioactive B-complex, chelated minerals, and antioxidants for men's health.

Daily Energy and Immunity
Ideal for boosting daily energy and immune support with methylated B-vitamins and vitamin D3.

Bioavailable Vitamins Praised
Customers praise bioavailable forms of vitamins, especially methylated B-vitamins and methylfolate.
9.0

Excellent

Our Rating
7

THORNE
THORNE Basic Nutrients 2/Day - Comprehensive Daily Multivitamin with Optimal Bioavailability - Vitamin & Mineral Formula - Gluten, Dairy & Soy-Free - 60 Capsules - 30 Servings
Main highlights

Comprehensive Formula for Wellness
Optimal Wellness: A daily supplement with key nutrients for health and wellness with just two capsules.

Ideal for Active Lifestyles
Perfect for individuals seeking foundational support for heart, brain, nerve, immune, bone, and skin health.

Highly Praised Energy Boost
Many users report noticeable energy improvements and enhanced mental clarity.
8.9

Very Good

Our Rating

9.3
worth the money

9.1
Absorbency

8.2
simple to consume
8

Nutricost

Nutricost Methylated Multivitamin 120 Capsules, 60 Servings - 23 Vitamin & Minerals Per Serving
8.8

Very Good

Our Rating
9

Pure Encapsulations
Pure Encapsulations O.N.E. Multivitamin - Once Daily Multivitamin with Antioxidant Complex Metafolin, CoQ10, and Lutein to Support Vision, Cognitive Function, and Cellular Health* - 60 Capsules
Main highlights

Comprehensive Nutrient Support
Includes vitamins A, B, C, D, E, CoQ10, L-5-MTHF, and ALA for antioxidant and cognitive support.

Ideal for Energy Boost
Best used for enhancing energy levels and cognitive function in active individuals.

Energy Enhancement Praised
Customers frequently commend the multivitamin for significantly boosting energy and improving daily vitality.
8.5

Good

Our Rating

9.1
simple to consume

9.1
worth the money

9.1
quality of ingredients
10

Power By Naturals
Power By Naturals Methyl Multi One - Iron-Free Methylated Multivitamin with Quatrefolic 5-MTHF, Active B12, P5P, CoQ10 & Zinc for MTHFR Support - Energy & Focus Formula - 60 Capsules (2-Month Supply)
Main highlights

Comprehensive Nutrition Solution
Offers a blend of 27 vitamins and minerals, including methylated B complex, ADK, C, and E for easy absorption and overall wellness.

Ideal for MTHFR Support
Designed for individuals with MTHFR gene variants, optimizing methylation with bioactive folate and methyl B12/B6.

Highly Praised Quality
Customers appreciate the high-quality ingredients and noticeable health improvements, particularly in focus and emotional balance.
8.4

Good

Our Rating

9.1
quality of ingredients

8.7
simple to consume

8.0
Flavor

10 Best methylated multivitamins of 2025

1

10X Health Optimize Methylated Multivitamin for Men & Women - 34 in 1 Formula with 800 mcg of Vitamin B12, Vitamin E, 5-MTHF, B Complex, NAC, Magnesium & Zinc Multivitamins - 90 Capsules

2

Methyl Multi Without Iron Methylated Multivitamin for Men & Women, 120-Day Supply | Methyl B12 & Methylfolate (5-MTHF) for MTHFR Support | Pharma Grade Multivitamin & Multimineral For Health, 240 Caps

9.9

9.5

9.5

3

Methylated Multivitamin - B-Complex with Methylfolate & B12 - for Men & Women - 9-in-1 MTHFR Supplement with TMG - for Energy, Brain & Mood - Vegan, Lab Tested - Made in USA - 120 Capsules, One/Day

4

Pure Methylated Multivitamin for Men & Women | 240 Capsules with Vitamins C, D, B12, Thiamin, Folate + Magnesium, Zinc, & More | High Absorption | Bioactive Vitamin & Mineral Complex | Filler Free

5

Methylated Multivitamin (Methylated and Activated Vitamins Only - B Complex with Trimethylglycine (TMG) and Methylfolate)(Non-GMO, Gluten Free MTHFR Supplement) 120 Capsules by Double Wood

6

Igennus Methylated Men's Multivitamin, MTHFR Supplement with Active B-Vitamins, 21 Highly Bioavailable Nutrients, Multivitamin for Sustained Release, Clean Label, Non-GMO & Halal 60 Tablets

7

THORNE Basic Nutrients 2/Day - Comprehensive Daily Multivitamin with Optimal Bioavailability - Vitamin & Mineral Formula - Gluten, Dairy & Soy-Free - 60 Capsules - 30 Servings

9.3

9.1

8.2

8

Nutricost Methylated Multivitamin 120 Capsules, 60 Servings - 23 Vitamin & Minerals Per Serving

9

Pure Encapsulations O.N.E. Multivitamin - Once Daily Multivitamin with Antioxidant Complex Metafolin, CoQ10, and Lutein to Support Vision, Cognitive Function, and Cellular Health* - 60 Capsules

9.1

9.1

9.1

10

Power By Naturals Methyl Multi One - Iron-Free Methylated Multivitamin with Quatrefolic 5-MTHF, Active B12, P5P, CoQ10 & Zinc for MTHFR Support - Energy & Focus Formula - 60 Capsules (2-Month Supply)

9.1

8.7

8.0

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