10 Best leptin resistance supplements for weight losses of 2025

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1

Dr. Westin Childs
Dr. Westin Childs | Leptin Resistance Rx – Natural Leptin Sensitizer Support Supplement for Women for Thyroid, Metabolic Health, Vitality, Energy, Focus with Glycosaminoglycans, Vitamin C - 60 ct
Main highlights

Leptin Sensitivity Enhancement
Supports leptin sensitivity, hormone balance, and thyroid function for a slender physique.

Ideal for Weight Management
Best used with exercise, whole foods, and intermittent fasting for optimal results.

Energy and Focus Boost
Customers love the boost in energy and focus it provides.
Key specs
- Weight Loss Support:Encourages calorie burning
- Formulation:Capsules
- Natural Ingredients:All-natural formula
- Serving Size:1 capsule daily
- Appetite Control:Supports leptin sensitivity
9.7

Exceptional

Our Rating
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Value for Money

2

DAVINCI

DAVINCI Labs Adipo-Leptin Benefits Dietary Supplement - Hormone Balance Support & Metabolism Support with Green Tea Extract, Green Coffee Bean Extract & More* - 60 Vegetarian Capsules (30 Servings)
9.6

Exceptional

Our Rating
3

NatureGenX
NatureGenX LeptinXT - Leptin Supplements for Weight Loss for Women, Healthy Fat Burner Pills, Advanced Strength Fat Burners for Women Weight Loss, Ideal Womens Fat Burner & Diet Pills, 60 Ct.
Main highlights

Supports Weight Loss Goals
NatureGenX Leptin XT helps reduce calorie intake by influencing leptin hunger hormones, best combined with a calorie-controlled diet and exercise.

Ideal for Women Seeking Natural Weight Loss
Crafted with natural ingredients like garcinia cambogia, green tea extract, and raspberry ketones, it supports women's weight loss journey and appetite control.

Customer Praise for Appetite Suppression
Users appreciate its ability to curb hunger, reduce binge eating, and increase energy levels, contributing to a more active and focused lifestyle.
9.5

Excellent

Our Rating
4

Life Extension
Life Extension AMPK Metabolic Activator, hesperidin, G. pentaphyllum, fight unwanted belly fat & revitalize cellular metabolism, gluten-free, non-GMO, 30 Vegetarian Tablets

35% Off
Main highlights

Fat Reduction Enzyme Activation
Triggers AMPK activity to help burn abdominal fat.

Best for Balanced Diets
Ideal for use with protein-rich diets and exercise.

Appetite Control
Users praise its ability to curb appetite effectively.
Key specs
- Ingredients:Hesperidin, G. pentaphyllum
- Benefits:Burn belly fat
- Metabolism:Triggers AMPK activity
- Usage:N/A
- Sleep Support:N/A
9.4

Excellent

Our Rating

8.0
worth the money

8.0
Flavor
5

Power By Naturals
Power By Naturals Leptin Supplements for Weight Loss for Women – Weightloss Supplements Women with African Mango, Green Tea & Apple Cider Vinegar – 60 Capsules
Main highlights

Key Features and Benefits
Natural weight management with leptin optimization, reduces cravings, and promotes fat utilization, enriched with caffeine and green tea for energy and focus.

Ideal Use Cases
Best for women seeking a natural approach to balance diet, reduce hunger, and support an active lifestyle with mental clarity and energy.

Customer Reviews Highlight
Most praised for effectively reducing cravings and boosting energy without artificial ingredients, leading to noticeable weight management results.
Key specs
- Weight Loss Support:Leptin supplements
- Formulation:Herb-infused formula
- Natural Ingredients:Caffeine, raspberry ketones
- Serving Size:Two veggie capsules
- Appetite Control:Leptin-driven management
9.2

Excellent

Our Rating

8.0
Flavor

8.0
worth the money
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6

Health As It Ought To Be

Health As It Ought To Be Leptin Syn3rgy Supplement | Physician Formulated Capsules with Green Tea, African Mango, Ginseng | 60 Capsules
9.0

Excellent

Our Rating
7

Plus+Ultra
GLP-1 Supplement for Women and Men | Hunger & Metabolism Support - Expert Formulated to Support GLP1 Naturally | Probiotic and Prebiotic (60 Capsules)

16% Off
Main highlights

Appetite Control and Weight Management
Activates GLP-1 hormone for natural appetite control and weight management.

Daily Use for Best Results
Best used consistently for 3 months for optimal weight management.

Clinically Validated Ingredients
Praised for including Berberine, Cinnamon, Turmeric, and more for effective GLP production.
Key specs
- Weight Loss Support:Natural weight management
- Formulation:Capsule
- Natural Ingredients:Berberine, Cinnamon, Turmeric
- Serving Size:1 capsule, 2 times
- Appetite Control:GLP-1 activation
8.9

Very Good

Our Rating
8

Power By Naturals
Power By Naturals Leptin Detox Cleanse for Reduce Weight - Natural Gut & Colon Cleanser, 1532mg, Acai Berry Cleanse for Men & Women, 60 Capsules, USA-Made
Main highlights

Kick-Start Healthy Weight Loss & Colon Cleanser
This detox formula naturally increases energy, flushes excess waste and toxins, and supports healthy digestion with all-natural ingredients.

Ideal for Overindulgence & Digestive Issues
Perfect for those struggling with gas, bloating, or following a ketogenic diet. Also great for rebooting before starting a diet.

Praised for Gentle & Effective Detox
Customers love that it works fast without causing cramps or constipation, helps with bloating, and increases energy levels.
8.8

Very Good

Our Rating

9.9
simple to consume

9.3
quality of ingredients

8.0
pain management
9

NutriFlair
NutriFlair Premium Berberine HCL 1200mg, 120 Capsules - Plus Pure True Ceylon Cinnamon, Berberine HCI Root Supplements Pills - Immune System - yields an Optimal 8% HCl
Main highlights

High Potency and Natural Ingredients
NutriFlair Berberine HCL 1200 mg with Ceylon Cinnamon supports metabolism, immune health, and digestion using vegan, non-GMO, gluten-free ingredients.

Ideal for Blood Sugar and Weight Management
Designed to support healthy blood sugar levels and weight management, perfect for individuals seeking natural health solutions.

Effective and Potent Supplement
Customers praise its effectiveness, noting improvements in digestion and metabolic support, though caution is advised when mixing with medications.
8.7

Very Good

Our Rating

9.3
quality of ingredients

9.1
simple to consume

8.9
worth the money
10

Wellness Resources

Wellness Resources Leptinal - The Leptin Helper - Supplement for Optimal Leptin Function, Metabolism, Cardiovascular Health, Thyroid (90 Capsules)
8.6

Very Good

Our Rating

10 Best leptin resistance supplements for weight losses of 2025

1

Dr. Westin Childs | Leptin Resistance Rx – Natural Leptin Sensitizer Support Supplement for Women for Thyroid, Metabolic Health, Vitality, Energy, Focus with Glycosaminoglycans, Vitamin C - 60 ct

How do we rank?

How do we rank?

Analyzing top stores

2

DAVINCI Labs Adipo-Leptin Benefits Dietary Supplement - Hormone Balance Support & Metabolism Support with Green Tea Extract, Green Coffee Bean Extract & More* - 60 Vegetarian Capsules (30 Servings)

3

NatureGenX LeptinXT - Leptin Supplements for Weight Loss for Women, Healthy Fat Burner Pills, Advanced Strength Fat Burners for Women Weight Loss, Ideal Womens Fat Burner & Diet Pills, 60 Ct.

4

Life Extension AMPK Metabolic Activator, hesperidin, G. pentaphyllum, fight unwanted belly fat & revitalize cellular metabolism, gluten-free, non-GMO, 30 Vegetarian Tablets

8.0

8.0

5

Power By Naturals Leptin Supplements for Weight Loss for Women – Weightloss Supplements Women with African Mango, Green Tea & Apple Cider Vinegar – 60 Capsules

8.0

8.0

6

Health As It Ought To Be Leptin Syn3rgy Supplement | Physician Formulated Capsules with Green Tea, African Mango, Ginseng | 60 Capsules

7

GLP-1 Supplement for Women and Men | Hunger & Metabolism Support - Expert Formulated to Support GLP1 Naturally | Probiotic and Prebiotic (60 Capsules)

8

Power By Naturals Leptin Detox Cleanse for Reduce Weight - Natural Gut & Colon Cleanser, 1532mg, Acai Berry Cleanse for Men & Women, 60 Capsules, USA-Made

9.9

9.3

8.0

9

NutriFlair Premium Berberine HCL 1200mg, 120 Capsules - Plus Pure True Ceylon Cinnamon, Berberine HCI Root Supplements Pills - Immune System - yields an Optimal 8% HCl

9.3

9.1

8.9

10

Wellness Resources Leptinal - The Leptin Helper - Supplement for Optimal Leptin Function, Metabolism, Cardiovascular Health, Thyroid (90 Capsules)

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