July 9, 2025

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10 Best l methylfolate supplements of 2025

Save up to 26% off

Best Choice

1

MethylPro
MethylPro 15mg L-Methylfolate - (90 Capsules)
Main highlights

Mood and Cardiovascular Support
L-Methylfolate 15mg helps promote serotonin, norepinephrine, and dopamine production for mood and heart health.

Ideal for MTHFR Variants
Best for individuals with genetic MTHFR variations needing active folate absorption.

Customer Praised Absorption
Users appreciate the supplement's superior absorption and effectiveness.
9.9

Exceptional

Our Rating

9.9
Flavor

9.9
simple to consume

9.7
Absorbency
How do we rank?

Powerful technology We scan thousands of products and stores, analyzing reviews to find what matters most to users like you

Careful review Our team ensures quality, value, and fit based on real user feedback

Trusted insights AI and human analysis guide your decisions, reflecting real user priorities
Real users impact

Thousands of users trust our site daily

Based on millions of stores and reviews

Shoppers influence our rankings
Analyzing top stores
Value for Money

2

Carlyle
Carlyle L Methylfolate 15mg | 120 Capsules | Value Size | Max Potency | Optimized and Activated | Non-GMO, Gluten Free | Methyl Folate, 5-MTHF | by Opti-Folate

14% Off
Main highlights

High Potency Formula
Delivers 25,000 mcg Folate and 15 mg L-Methylfolate for maximum efficacy.

Ideal for Genetic Conditions
Perfect for individuals with genetic conditions affecting folate metabolism.

Praised for Affordability
Customers appreciate the cost-effectiveness compared to prescription alternatives.
9.6

Exceptional

Our Rating

9.9
simple to consume

9.9
Absorbency

9.5
worth the money
3

Triquetra Health
L Methyl Folate 15mg Plus Methyl B12 Cofactor – High Potency, Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive Forms of Vitamin B9 & B12 (60 Capsules – 60 Servings)
Main highlights

Active Folate and B12 Support
Provides 15mg L-Methyl Folate and Methyl B12 for optimal body function.

Ideal for Mood and Energy
Perfect for enhancing mood, energy, and cognitive function.

Praised for Mood Improvement
Users report improved mood and energy levels within days.
9.3

Excellent

Our Rating

9.7
simple to consume

9.7
worth the money

9.7
Absorbency
4

Life Extension
Life Extension Optimized Folate – L-methylfolate – Heart & Brain Support, Healthy Homocysteine Levels – Non-GMO, Gluten-Free, Vegetarian – 1700 mcg DFE, 100 Vegetarian Tablets
Main highlights

Optimal Cognitive Support
This folate supplement supports brain health and optimal cognitive function as you age.

Ideal for MTHFR Mutation
Best for individuals with MTHFR mutation needing L-methylfolate supplementation.

Highly Effective Methylfolate
Praised for its high-quality, effective L-methylfolate form over folic acid.
9.2

Excellent

Our Rating

9.3
simple to consume

9.3
worth the money

9.1
Flavor
5

Triquetra Health
L Methyl Folate 15mg Plus Methyl B12 Cofactor – Organic Berry Flavor, High Potency Liquid Sublingual Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive Forms Vitamin B9 & B12 (1oz)
Main highlights

Key Features and Benefits
Clinically validated 15mg L-Methylfolate in active form for superior absorption, with essential Methyl B12 for methylation and homocysteine breakdown.

Ideal Use Cases
Ideal for supporting brain, mood, energy, cardiovascular health, and nerve function, especially in those with methylation issues who can`t process folic acid.

Customer Reviews Summary
Highly praised for its effective support of mood and energy levels, with the cherry-flavored, sublingual form noted for its ease of use.
9.1

Excellent

Our Rating

9.7
simple to consume

9.7
Absorbency

9.5
worth the money
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6

NatureBell
NatureBell L Methylfolate 15mg, 240 Veggie Capsules | 5-MTHF with Methyl B12 1,000mcg | High Potency Dual Action for Energy & Cognitive Support, Active Folic Acid – Methyl Folate Supplement

26% Off
Main highlights

High Potency Energy Support
Combines Methyl Folate 15mg and Vitamin B12 for enhanced energy and cognitive health.

Ideal for MTHFR Mutation
Perfect for those needing methylated folate and B12 for genetic conditions.

Highly Praised Combination
Customers appreciate the brain support and focus benefits of this supplement.
9.0

Excellent

Our Rating
7

Nutricost
Nutricost Methylfolate 1000mcg, 120 Vegetarian Capsules - Gluten Free, Non-GMO

18% Off
Main highlights

High Potency Formula
Contains 1,000mcg Methyl Folate per serving; 120 servings total.

Ideal for Energy Boost
Perfect for individuals seeking enhanced energy and mood improvement.

Praised for Value
Customers frequently commend its affordability and noticeable benefits.
8.9

Very Good

Our Rating

9.5
simple to consume

9.5
Flavor

9.1
Absorbency
8

Carlyle
Carlyle L Methylfolate 7.5 mg | 60 Capsules | Optimized and Activated | Non-GMO, Gluten Free | Methyl Folate, 5-MTHF | by Opti-Folate
Main highlights

Key Features and Benefits
L-Methylfolate 7.5 mg capsules boost mental clarity and focus.

Ideal Use Cases
Perfect for individuals with MTHFR gene mutation needing folate.

Praised Feature from Reviews
Notable improvement in mental clarity and expression.
8.8

Very Good

Our Rating

9.5
simple to consume

9.3
Flavor

9.1
worth the money
9

THORNE
THORNE 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation, and Homocysteine Levels* - 60 Capsules - 5-MTHF 1mg
Main highlights

Supports Cardiovascular and Nerve Health
Thorne 5-MTHF provides active folate for cardiovascular, nerve health, and methylation support.

Ideal for MTHFR Gene Mutation
Perfect for individuals with MTHFR mutation needing enhanced folate absorption.

Improves Focus and Mood
Customers praise its ability to enhance focus, mood, and overall well-being.
8.7

Very Good

Our Rating

9.9
simple to consume

9.5
Absorbency

9.3
worth the money
10

Triquetra Health
L Methylfolate 7.5mg plus Methyl B12 - Active 5-MTHF Form, MTHFR Supplement - Bloodstream Ready Methylated Folate + B12 Cofactor - Supports Mood, Homocysteine Methylation, Cognition (60 Capsules)
Main highlights

Bioavailable Active Folate and B12
Contains 7.5mg L-Methylfolate and Methyl B12 for optimal absorption and metabolism.

Ideal for Methylation Support
Perfect for those with methylation issues needing active folate and B12.

Customer Praises for Energy Boost
Users report significant improvements in energy and mood after use.
8.4

Good

Our Rating

10 Best l methylfolate supplements of 2025

1

MethylPro 15mg L-Methylfolate - (90 Capsules)

9.9

9.9

9.7

How do we rank?

How do we rank?

Analyzing top stores

2

Carlyle L Methylfolate 15mg | 120 Capsules | Value Size | Max Potency | Optimized and Activated | Non-GMO, Gluten Free | Methyl Folate, 5-MTHF | by Opti-Folate

9.9

9.9

9.5

3

L Methyl Folate 15mg Plus Methyl B12 Cofactor – High Potency, Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive Forms of Vitamin B9 & B12 (60 Capsules – 60 Servings)

9.7

9.7

9.7

4

Life Extension Optimized Folate – L-methylfolate – Heart & Brain Support, Healthy Homocysteine Levels – Non-GMO, Gluten-Free, Vegetarian – 1700 mcg DFE, 100 Vegetarian Tablets

9.3

9.3

9.1

5

L Methyl Folate 15mg Plus Methyl B12 Cofactor – Organic Berry Flavor, High Potency Liquid Sublingual Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive Forms Vitamin B9 & B12 (1oz)

9.7

9.7

9.5

6

NatureBell L Methylfolate 15mg, 240 Veggie Capsules | 5-MTHF with Methyl B12 1,000mcg | High Potency Dual Action for Energy & Cognitive Support, Active Folic Acid – Methyl Folate Supplement

7

Nutricost Methylfolate 1000mcg, 120 Vegetarian Capsules - Gluten Free, Non-GMO

9.5

9.5

9.1

8

Carlyle L Methylfolate 7.5 mg | 60 Capsules | Optimized and Activated | Non-GMO, Gluten Free | Methyl Folate, 5-MTHF | by Opti-Folate

9.5

9.3

9.1

9

THORNE 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation, and Homocysteine Levels* - 60 Capsules - 5-MTHF 1mg

9.9

9.5

9.3

10

L Methylfolate 7.5mg plus Methyl B12 - Active 5-MTHF Form, MTHFR Supplement - Bloodstream Ready Methylated Folate + B12 Cofactor - Supports Mood, Homocysteine Methylation, Cognition (60 Capsules)

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