10 Best l methylfolate brands of 2025

Save up to 26% off

Best Choice

1

MethylPro
MethylPro 15mg L-Methylfolate - Professional Strength Active Methyl Folate Supplement for Brain Support, Balanced Mood + Immune Health - Gluten-Free with No Fillers (90 Capsules)

12% Off
Main highlights

Mood and Cardiovascular Support
L-Methylfolate 15mg helps promote serotonin, norepinephrine, and dopamine production for mood and heart health.

Ideal for MTHFR Variants
Best for individuals with genetic MTHFR variations needing active folate absorption.

Customer Praised Absorption
Users appreciate the supplement's superior absorption and effectiveness.
9.7

Exceptional

Our Rating

9.9
Flavor

9.9
simple to consume

9.7
Absorbency
How do we rank?

Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service levels, popularity trends, and more. The rankings reflect our opinion and should be a good starting point for shopping. By purchasing the products we rank, you’ll get the lowest price we found while we may receive a commission at no cost to you, which will help us continue to provide you with value.
Value for Money

2

Carlyle
Carlyle L Methylfolate 15mg | 120 Capsules | Value Size | Max Potency | Optimized and Activated | Non-GMO, Gluten Free | Methyl Folate, 5-MTHF | by Opti-Folate

14% Off
Main highlights

High Potency Formula
Delivers 25,000 mcg Folate and 15 mg L-Methylfolate for maximum efficacy.

Ideal for Genetic Conditions
Perfect for individuals with genetic conditions affecting folate metabolism.

Praised for Affordability
Customers appreciate the cost-effectiveness compared to prescription alternatives.
9.4

Excellent

Our Rating

9.9
simple to consume

9.9
Absorbency

9.5
worth the money
3

Carlyle
Carlyle L Methylfolate 7.5 mg | 60 Capsules | Optimized and Activated | Non-GMO, Gluten Free | Methyl Folate, 5-MTHF | by Opti-Folate
Main highlights

Key Features and Benefits
L-Methylfolate 7.5 mg capsules boost mental clarity and focus.

Ideal Use Cases
Perfect for individuals with MTHFR gene mutation needing folate.

Praised Feature from Reviews
Notable improvement in mental clarity and expression.
9.3

Excellent

Our Rating

9.5
simple to consume

9.3
Flavor

9.1
worth the money
4

Life Extension
Life Extension Optimized Folate – L-methylfolate – Heart & Brain Support, Healthy Homocysteine Levels – Non-GMO, Gluten-Free, Vegetarian – 1700 mcg DFE, 100 Vegetarian Tablets
Main highlights

Optimal Cognitive Support
This folate supplement supports brain health and optimal cognitive function as you age.

Ideal for MTHFR Mutation
Best for individuals with MTHFR mutation needing L-methylfolate supplementation.

Highly Effective Methylfolate
Praised for its high-quality, effective L-methylfolate form over folic acid.
9.2

Excellent

Our Rating

9.3
simple to consume

9.3
worth the money

9.1
Flavor
5

Triquetra Health
L Methylfolate 7.5mg plus Methyl B12 - Active 5-MTHF Form, MTHFR Supplement - Bloodstream Ready Methylated Folate + B12 Cofactor - Supports Mood, Homocysteine Methylation, Cognition (60 Capsules)
Main highlights

Bioavailable Active Folate and B12
Contains 7.5mg L-Methylfolate and Methyl B12 for optimal absorption and metabolism.

Ideal for Methylation Support
Perfect for those with methylation issues needing active folate and B12.

Customer Praises for Energy Boost
Users report significant improvements in energy and mood after use.
8.9

Very Good

Our Rating
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6

Nutricost

Nutricost L-Methylfolate 15mg, 120 Capsules (5-MTHF) - Vegan, Non-GMO, Gluten Free
8.8

Very Good

Our Rating
7

Carlyle
Carlyle L Methylfolate 15mg | 60 Capsules | Max Potency | Optimized and Activated | Non-GMO, Gluten Free | Methyl Folate, 5-MTHF | by Opti-Folate
Main highlights

Key Features and Benefits
Delivers 25,000 mcg of metabolically active L-Methylfolate for enhanced wellness, ensuring superior absorption and efficacy over standard Folic Acid.

Ideal Use Cases
Perfect for individuals needing nutritional support for cardiovascular, neurologic health, and those seeking to enhance mood and mental clarity.

Customer Reviews Highlight
Widely praised for its effectiveness in improving mood and energy levels, with many noting significant health improvements within weeks of use.
8.6

Very Good

Our Rating

9.3
simple to consume

9.1
worth the money

8.9
Flavor
8

NatureBell
NatureBell L Methylfolate 15mg, 240 Veggie Capsules | 5-MTHF with Methyl B12 1,000mcg | High Potency Dual Action for Energy & Cognitive Support, Active Folic Acid – Methyl Folate Supplement

26% Off
Main highlights

High Potency Energy Support
Combines Methyl Folate 15mg and Vitamin B12 for enhanced energy and cognitive health.

Ideal for MTHFR Mutation
Perfect for those needing methylated folate and B12 for genetic conditions.

Highly Praised Combination
Customers appreciate the brain support and focus benefits of this supplement.
8.5

Good

Our Rating
9

Carlyle

Carlyle L Methylfolate 1000mcg | 200 Capsules | Value Size | Optimized and Activated | Non-GMO, Gluten Free | Methyl Folate, 5-MTHF | by Opti-Folate
8.4

Good

Our Rating

9.9
Absorbency

9.7
simple to consume

9.7
Flavor
10

Basigano

Basigano 15mg L Methylfolate (5-MTHF)- Active Folic Acid-Enriched with Vitamins B6 and B12-60 Vegetarian Capsules - Non-GMO, Gluten-Free
8.2

Good

Our Rating

10 Best l methylfolate brands of 2025

1

MethylPro 15mg L-Methylfolate - Professional Strength Active Methyl Folate Supplement for Brain Support, Balanced Mood + Immune Health - Gluten-Free with No Fillers (90 Capsules)

9.9

9.9

9.7

2

Carlyle L Methylfolate 15mg | 120 Capsules | Value Size | Max Potency | Optimized and Activated | Non-GMO, Gluten Free | Methyl Folate, 5-MTHF | by Opti-Folate

9.9

9.9

9.5

3

Carlyle L Methylfolate 7.5 mg | 60 Capsules | Optimized and Activated | Non-GMO, Gluten Free | Methyl Folate, 5-MTHF | by Opti-Folate

9.5

9.3

9.1

4

Life Extension Optimized Folate – L-methylfolate – Heart & Brain Support, Healthy Homocysteine Levels – Non-GMO, Gluten-Free, Vegetarian – 1700 mcg DFE, 100 Vegetarian Tablets

9.3

9.3

9.1

5

L Methylfolate 7.5mg plus Methyl B12 - Active 5-MTHF Form, MTHFR Supplement - Bloodstream Ready Methylated Folate + B12 Cofactor - Supports Mood, Homocysteine Methylation, Cognition (60 Capsules)

6

Nutricost L-Methylfolate 15mg, 120 Capsules (5-MTHF) - Vegan, Non-GMO, Gluten Free

7

Carlyle L Methylfolate 15mg | 60 Capsules | Max Potency | Optimized and Activated | Non-GMO, Gluten Free | Methyl Folate, 5-MTHF | by Opti-Folate

9.3

9.1

8.9

8

NatureBell L Methylfolate 15mg, 240 Veggie Capsules | 5-MTHF with Methyl B12 1,000mcg | High Potency Dual Action for Energy & Cognitive Support, Active Folic Acid – Methyl Folate Supplement

9

Carlyle L Methylfolate 1000mcg | 200 Capsules | Value Size | Optimized and Activated | Non-GMO, Gluten Free | Methyl Folate, 5-MTHF | by Opti-Folate

9.9

9.7

9.7

10

Basigano 15mg L Methylfolate (5-MTHF)- Active Folic Acid-Enriched with Vitamins B6 and B12-60 Vegetarian Capsules - Non-GMO, Gluten-Free

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