June 27, 2025

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10 Best l 5 methylfolates of 2025

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1

Designs for Health
Designs for Health L 5-MTHF - Quatrefolic L Methylfolate Supplement 1mg (1700mcg DFE) - Methylated Folate Supplement for Women & Men - Supports Methylation - Non-GMO, Gluten Free (120 Capsules)
Main highlights

Bio-Active Folate for Brain and Energy Support
L-5-MTHF provides folate in the bioidentical, bioactive form 5-methyltetrahydrofolate, supporting brain function, energy levels, and healthy homocysteine pathways.

Ideal for Individuals with MTHFR Gene Mutation
L-5-MTHF is perfect for those who cannot process standard folic acid, offering high bioavailability and stability, essential for methylation and overall health.

Highly Recommended by Functional Medicine Professionals
Praised for its quality and effectiveness, this supplement is trusted by both allergists and gynecologists, making it a top choice among practitioners.
Key specs
- Form:Capsule
- Active Ingredient:5-methyltetrahydrofolate
- Dosage:1mg per capsule
- Bioavailability:High bioavailability
- GMP Certified:N/A
9.8

Exceptional

Our Rating

9.9
quality of ingredients

9.3
materials Quality

8.2
worth the money
How do we rank?

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Based on millions of stores and reviews

Shoppers influence our rankings
Analyzing top stores
Value for Money

2

MD.LIFE
MD Life L-Methylfolate 5mg - Professional-Grade Active Methylfolate Supplement - Maximum Potency MTHFR Supplements - L methylfolate 5mg 90 Capsules - Essential Amino Acids
Main highlights

Key Features
High-potency, enhanced absorption L-Methylfolate 5mg; GMO-free, gluten-free, vegan; designed for maximum bioavailability and peak performance.

Ideal Use Cases
Perfect for those seeking to complement their nutrition and wellness routines with a high-quality, pure supplement under physician supervision.

Customer Reviews Highlight
Most praised for its effectiveness and quality, with users noting significant improvements in well-being and appreciating its purity and ingredient integrity.
9.7

Exceptional

Our Rating

9.7
simple to consume

9.5
Absorbency

9.1
worth the money
3

Triquetra Health
L Methyl Folate 15mg Plus Methyl B12 Cofactor – Organic Berry Flavor, High Potency Liquid Sublingual Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive Forms Vitamin B9 & B12 (1oz)
Main highlights

Key Features and Benefits
Clinically validated 15mg L-Methylfolate in active form for superior absorption, with essential Methyl B12 for methylation and homocysteine breakdown.

Ideal Use Cases
Ideal for supporting brain, mood, energy, cardiovascular health, and nerve function, especially in those with methylation issues who can`t process folic acid.

Customer Reviews Summary
Highly praised for its effective support of mood and energy levels, with the cherry-flavored, sublingual form noted for its ease of use.
Key specs
- Form:Liquid sublingual
- Active Ingredient:L Methyl folate
- Dosage:15mg
- Bioavailability:Enhanced sublingual absorption
- GMP Certified:N/A
9.6

Exceptional

Our Rating

9.7
simple to consume

9.7
Absorbency

9.5
worth the money
4

MethylPro
MethylPro L-Methylfolate 5 mg - L Methyl Folate, Methylfolate Supplement for Women & Men, Methylated Vitamin B9 (5-MTHF) for Brain Health, Focus, Calm - 30 Capsules (Pack of 1)
Main highlights

Key Features
Enhances serotonin, norepinephrine, and dopamine production, offers superior bioavailability, and supports cardiovascular and cognitive health without fillers.

Ideal Use Cases
Best for individuals with MTHFR gene variations, those needing mood support, or anyone seeking enhanced cardiovascular and nerve function.

Customer Reviews
Highly praised for its effectiveness in improving mood and mental clarity, with noticeable benefits for those with genetic folate conversion issues.
Key specs
- Form:Supplement
- Active Ingredient:L-Methylfolate
- Dosage:5 mg
- Bioavailability:Heightened
- GMP Certified:N/A
9.3

Excellent

Our Rating

9.7
simple to consume

9.3
Absorbency

8.9
worth the money
5

Seeking Health
Seeking Health L-5-MTHF, Supports Healthy Methylation, Easily Absorbed Methyl Folate Supplement, MTHFR Support Supplement, 1,700 mcg DFE, Vegetarian (60 Capsules)
Main highlights

Targeted Support and Easy Absorption
Each bottle contains 60 capsules of 1,700 mcg DFE L-5 MTHF, supporting MTHFR gene mutations, cognition, mood, methylation, and homocysteine levels. Optimized for easy absorption.

Prenatal and Genetic Mutation Support
Ideal for pregnant women, individuals with MTHFR gene mutations, and those needing enhanced folate absorption. Supports fetal development, nervous system, and overall health.

No Side Effects and Easy to Swallow
Customers appreciate that the capsules are easy to swallow, do not cause side effects, and are free from common allergens and artificial additives.
9.1

Excellent

Our Rating

9.9
simple to consume

9.9
quality of ingredients

9.9
Flavor
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6

Carlyle
Carlyle L Methylfolate 15mg | 120 Capsules | Value Size | Max Potency | Optimized and Activated | Non-GMO, Gluten Free | Methyl Folate, 5-MTHF | by Opti-Folate

14% Off
Main highlights

High Potency Formula
Delivers 25,000 mcg Folate and 15 mg L-Methylfolate for maximum efficacy.

Ideal for Genetic Conditions
Perfect for individuals with genetic conditions affecting folate metabolism.

Praised for Affordability
Customers appreciate the cost-effectiveness compared to prescription alternatives.
8.8

Very Good

Our Rating

9.9
simple to consume

9.9
Absorbency

9.5
worth the money
7

THORNE
THORNE 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation, and Homocysteine Levels* - 60 Capsules - 5-MTHF 1mg
Main highlights

Supports Cardiovascular and Nerve Health
Thorne 5-MTHF provides active folate for cardiovascular, nerve health, and methylation support.

Ideal for MTHFR Gene Mutation
Perfect for individuals with MTHFR mutation needing enhanced folate absorption.

Improves Focus and Mood
Customers praise its ability to enhance focus, mood, and overall well-being.
8.7

Very Good

Our Rating

9.9
simple to consume

9.5
Absorbency

9.3
worth the money
8

Triquetra Health
L Methylfolate 7.5mg plus Methyl B12 - Active 5-MTHF Form, MTHFR Supplement - Bloodstream Ready Methylated Folate + B12 Cofactor - Supports Mood, Homocysteine Methylation, Cognition (60 Capsules)
Main highlights

Bioavailable Active Folate and B12
Contains 7.5mg L-Methylfolate and Methyl B12 for optimal absorption and metabolism.

Ideal for Methylation Support
Perfect for those with methylation issues needing active folate and B12.

Customer Praises for Energy Boost
Users report significant improvements in energy and mood after use.
Key specs
- Form:Capsule
- Active Ingredient:L Methylfolate 7.5mg
- Dosage:7.5mg
- Bioavailability:Immediate absorption
- GMP Certified:Yes
8.4

Good

Our Rating
9

Carlyle
Carlyle L Methylfolate 7.5 mg | 60 Capsules | Optimized and Activated | Non-GMO, Gluten Free | Methyl Folate, 5-MTHF | by Opti-Folate
Main highlights

Key Features and Benefits
L-Methylfolate 7.5 mg capsules boost mental clarity and focus.

Ideal Use Cases
Perfect for individuals with MTHFR gene mutation needing folate.

Praised Feature from Reviews
Notable improvement in mental clarity and expression.
Key specs
- Form:Quick-release capsules
- Active Ingredient:L-METHYLFOLATE
- Dosage:12,500 mcg
- Bioavailability:N/A
- GMP Certified:N/A
8.3

Good

Our Rating

9.5
simple to consume

9.3
Flavor

9.1
worth the money
10

NUTRAHARMONY
L Methylfolate 15 mg - 5-MTHF Methylfolate Supplement - plus Methyl B12, Vitamins B2 & B6, Magnesium - BioActive Vitamin B9 - Methylation Support, Energy & Brain - Made in USA, 60 Capsules for 2 Month
Main highlights

Superior Absorption and Bioavailability
The 5-MTHF capsules offer high-potency methylfolate for optimal health support with superior absorption.

Ideal for Cognitive and Mood Support
Perfect for enhancing memory, focus, and clarity, supporting energy and mood.

Praised for Quality and Purity
Customers appreciate the non-GMO, vegan, and GMP-certified formula made in the USA.
Key specs
- Form:Capsules
- Active Ingredient:5-MTHF Methylfolate
- Dosage:15 mg
- Bioavailability:High
- GMP Certified:Yes
8.2

Good

Our Rating

10 Best l 5 methylfolates of 2025

1

Designs for Health L 5-MTHF - Quatrefolic L Methylfolate Supplement 1mg (1700mcg DFE) - Methylated Folate Supplement for Women & Men - Supports Methylation - Non-GMO, Gluten Free (120 Capsules)

9.9

9.3

8.2

How do we rank?

How do we rank?

Analyzing top stores

2

MD Life L-Methylfolate 5mg - Professional-Grade Active Methylfolate Supplement - Maximum Potency MTHFR Supplements - L methylfolate 5mg 90 Capsules - Essential Amino Acids

9.7

9.5

9.1

3

L Methyl Folate 15mg Plus Methyl B12 Cofactor – Organic Berry Flavor, High Potency Liquid Sublingual Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive Forms Vitamin B9 & B12 (1oz)

9.7

9.7

9.5

4

MethylPro L-Methylfolate 5 mg - L Methyl Folate, Methylfolate Supplement for Women & Men, Methylated Vitamin B9 (5-MTHF) for Brain Health, Focus, Calm - 30 Capsules (Pack of 1)

9.7

9.3

8.9

5

Seeking Health L-5-MTHF, Supports Healthy Methylation, Easily Absorbed Methyl Folate Supplement, MTHFR Support Supplement, 1,700 mcg DFE, Vegetarian (60 Capsules)

9.9

9.9

9.9

6

Carlyle L Methylfolate 15mg | 120 Capsules | Value Size | Max Potency | Optimized and Activated | Non-GMO, Gluten Free | Methyl Folate, 5-MTHF | by Opti-Folate

9.9

9.9

9.5

7

THORNE 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation, and Homocysteine Levels* - 60 Capsules - 5-MTHF 1mg

9.9

9.5

9.3

8

L Methylfolate 7.5mg plus Methyl B12 - Active 5-MTHF Form, MTHFR Supplement - Bloodstream Ready Methylated Folate + B12 Cofactor - Supports Mood, Homocysteine Methylation, Cognition (60 Capsules)

9

Carlyle L Methylfolate 7.5 mg | 60 Capsules | Optimized and Activated | Non-GMO, Gluten Free | Methyl Folate, 5-MTHF | by Opti-Folate

9.5

9.3

9.1

10

L Methylfolate 15 mg - 5-MTHF Methylfolate Supplement - plus Methyl B12, Vitamins B2 & B6, Magnesium - BioActive Vitamin B9 - Methylation Support, Energy & Brain - Made in USA, 60 Capsules for 2 Month

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