10 Best immune system supplements for dogs of 2025

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Best Choice

1

VetSmart Formulas
Critical Immune Defense for Dogs & Cats; Supports Normal Cell Growth - Turkey Tail, Reishi, Shiitake and Maitake Mushroom Formula with Patented White Turmeric Root Extract - 30-Day Supply
Main highlights

Key Features and Benefits
Enhances pet health with premium ingredients, supporting joint, coat, and overall wellness. Unique formula backed by veterinary science.

Ideal Use Cases
Perfect for aging pets, those with joint issues, or pets needing a nutritional boost for a shiny coat and improved vitality.

Customer Reviews Highlight
Most praised for significantly improving pets` mobility and energy, with noticeable results in joint health and activity levels.
9.7

Exceptional

Our Rating

8.2
Simple to use

8.2
Aroma

8.2
Comfort
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Value for Money

2

PetLab Co.
PetLab Co. Allergy & Immune Probiotics for Dogs, Support Seasonal Allergies, Gut & Digestive Health - Pork Flavor - 30 Soft Chews

13% Off
Main highlights

Supports Gut Balance and Immune Response
Advanced formula with probiotics for gut health and immune support.

Ideal for Seasonal Allergy Relief
Perfect for dogs with seasonal allergies to promote comfort.

Reduces Paw Licking and Biting
Most praised for reducing paw licking and biting in dogs.
9.6

Exceptional

Our Rating

8.0
Flavor

8.0
Aroma

8.0
worth the money
3

Zesty Paws
Zesty Paws Probiotics for Dogs - Digestive Enzymes for Gut Flora, Digestive Health, Diarrhea & Bowel Support - Clinically Studied DE111 - Dog Supplement Soft Chew for Pet Immune System - Pumpkin
Main highlights

Digestive and Immune Support
Contains DE111 probiotic and six-strain blend for gut health.

For All Dog Breeds
Ideal for small, medium, and large dogs needing digestive aid.

Reduces Gas and Bloating
Praised for eliminating unpleasant odors and digestive discomfort.
9.3

Excellent

Our Rating

9.9
Gentle

9.7
Comfort

9.3
worth the money
4

Standard Process Inc.

Standard Process Canine Immune System Support - Immune Support Supplement for Dogs - Powder Canine Supplement Aids Overall Health & Wellness - Immunity Support Supplement with Zinc & Kelp - 30 g
9.1

Excellent

Our Rating
5

Zesty Paws
Zesty Paws Multivitamin Treats for Dogs - Glucosamine Chondroitin for Joint Support + Digestive Enzymes & Probiotics - Grain Free Dog Vitamin for Skin & Coat + Immune Health - Chicken Flavor - 90ct
Main highlights

8-in-1 Formula Benefits
Comprehensive support for joints, skin, heart, immune, liver, and gut health.

Ideal for Dogs with Joint Issues
Perfect for senior dogs needing joint and skin support.

Praised for Skin and Coat Improvement
Significantly reduces shedding and enhances coat shine.
9.0

Excellent

Our Rating

9.3
worth the money

9.3
quality of ingredients

9.1
Flavor
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6

VETIQ
VetIQ Multivitamin Supplement for Dogs, Supports Active Brain Function, Immune System, and Digestive System, Hickory Smoke Flavored Dog Multivitamin, Made in The USA, 60 Count
Main highlights

Comprehensive Health Support
VetIQ Multivitamin aids brain, immune, and digestive systems.

Ideal for Training and Anxiety
Perfect for training and calming anxious dogs.

Highly Praised Flavor and Texture
Dogs love the hickory smoke flavor and soft chew texture.
8.9

Very Good

Our Rating

8.0
Flavor

8.0
Simple to use

8.0
worth the money
7

NaturVet

NaturVet Mushroom Max Advanced Immune Support Dog Supplement – Helps Strengthen Immunity, Overall Health for Dogs – Includes Shitake Mushrooms, Reishi, Turkey Tail – 60 Ct.
8.8

Very Good

Our Rating

9.1
Simple to use

8.9
worth the money

8.2
Flavor
8

Natural Dog Company

Natural Dog Company Aller-Immune Chews, Allergy Relief & Immune Support for Dogs, Itch Relief, Skin, Coat & Gut Health with Probiotics, Colostrum & Salmon Oil, Grain-Free Dog Supplement - 90 Chews

16% Off
8.6

Very Good

Our Rating
9

Wholistic Pet Organics
Wholistic Pet Organics Canine Complete Dog Multivitamin - 1 Lb - Nutrient-Rich Multi-Vitamins and Supplements - Whole-Food Powder for Immune System, Skin, Coat & Overall Health
Main highlights

Comprehensive Nutrition
Wholistic Canine Complete provides essential vitamins, minerals, probiotics, and antioxidants for overall dog health.

Versatile Use
Ideal for all dog ages and complements homemade and raw diets.

Improved Coat
Customers praise the supplement for enhancing their dog's coat health and reducing shedding.
8.3

Good

Our Rating

9.5
Simple to use

8.0
worth the money

8.0
Flavor
10

VETRISCIENCE
VetriScience Immunity Health Easy-Open Capsules, 23 Antioxidants for Cell Advance, Immune Plus Supplement for Medium to Large Breed Dogs, Immune and Allergy Support, 120 Count
Main highlights

23 Powerful Antioxidants
Immunity Health offers 23 antioxidants to boost immune health and protect against free-radical damage in all dog breeds and ages.

Ideal for All Breeds
Perfect for owners seeking immune support for dogs of any size, with specific formulas for small and medium/large breeds.

Easy-to-Use Capsules
Customers praise the convenience of capsules that can be added directly to meals or sprinkled over food.
8.2

Good

Our Rating

10 Best immune system supplements for dogs of 2025

1

Critical Immune Defense for Dogs & Cats; Supports Normal Cell Growth - Turkey Tail, Reishi, Shiitake and Maitake Mushroom Formula with Patented White Turmeric Root Extract - 30-Day Supply

8.2

8.2

8.2

2

PetLab Co. Allergy & Immune Probiotics for Dogs, Support Seasonal Allergies, Gut & Digestive Health - Pork Flavor - 30 Soft Chews

8.0

8.0

8.0

3

Zesty Paws Probiotics for Dogs - Digestive Enzymes for Gut Flora, Digestive Health, Diarrhea & Bowel Support - Clinically Studied DE111 - Dog Supplement Soft Chew for Pet Immune System - Pumpkin

9.9

9.7

9.3

4

Standard Process Canine Immune System Support - Immune Support Supplement for Dogs - Powder Canine Supplement Aids Overall Health & Wellness - Immunity Support Supplement with Zinc & Kelp - 30 g

5

Zesty Paws Multivitamin Treats for Dogs - Glucosamine Chondroitin for Joint Support + Digestive Enzymes & Probiotics - Grain Free Dog Vitamin for Skin & Coat + Immune Health - Chicken Flavor - 90ct

9.3

9.3

9.1

6

VetIQ Multivitamin Supplement for Dogs, Supports Active Brain Function, Immune System, and Digestive System, Hickory Smoke Flavored Dog Multivitamin, Made in The USA, 60 Count

8.0

8.0

8.0

7

NaturVet Mushroom Max Advanced Immune Support Dog Supplement – Helps Strengthen Immunity, Overall Health for Dogs – Includes Shitake Mushrooms, Reishi, Turkey Tail – 60 Ct.

9.1

8.9

8.2

8

Natural Dog Company Aller-Immune Chews, Allergy Relief & Immune Support for Dogs, Itch Relief, Skin, Coat & Gut Health with Probiotics, Colostrum & Salmon Oil, Grain-Free Dog Supplement - 90 Chews

9

Wholistic Pet Organics Canine Complete Dog Multivitamin - 1 Lb - Nutrient-Rich Multi-Vitamins and Supplements - Whole-Food Powder for Immune System, Skin, Coat & Overall Health

9.5

8.0

8.0

10

VetriScience Immunity Health Easy-Open Capsules, 23 Antioxidants for Cell Advance, Immune Plus Supplement for Medium to Large Breed Dogs, Immune and Allergy Support, 120 Count

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