August 25, 2025

Advertising Disclosure

10 Best immune system supplements for dogs of 2025

Save up to 24% off

Best Choice

1

VetSmart Formulas
Critical Immune Defense for Dogs & Cats; Supports Normal Cell Growth - Turkey Tail, Reishi, Shiitake and Maitake Mushroom Formula with Patented White Turmeric Root Extract - 30-Day Supply
Main highlights

Key Features and Benefits
Enhances pet health with premium ingredients, supporting joint, coat, and overall wellness. Unique formula backed by veterinary science.

Ideal Use Cases
Perfect for aging pets, those with joint issues, or pets needing a nutritional boost for a shiny coat and improved vitality.

Customer Reviews Highlight
Most praised for significantly improving pets` mobility and energy, with noticeable results in joint health and activity levels.
9.7

Exceptional

Our Rating

8.2
Simple to use

8.2
Aroma

8.2
Comfort
How do we rank?

Powerful technology We scan thousands of products and stores, analyzing reviews to find what matters most to users like you

Careful review Our team ensures quality, value, and fit based on real user feedback

Trusted insights AI and human analysis guide your decisions, reflecting real user priorities
Real users impact

Thousands of users trust our site daily

Based on millions of stores and reviews

Shoppers influence our rankings
Analyzing top stores
Value for Money

2

Wuffes

Wuffes 23-in-1 Dog Multivitamin Supplement for Hip & Joint, Skin & Coat and Immune System Support with Omega 3, Iron, Zinc, Vitamin C - Minerals & Vitamins for Senior Dogs and Puppies - 30 Soft Chews
9.6

Exceptional

Our Rating

8.4
Flavor

8.0
pain management

8.0
worth the money
3

Zesty Paws
Zesty Paws Dog Allergy Relief- Dog Itching Skin Relief- Dog Probiotics for Itchy Skin and Itchy Ears- Dog Allergy Paw Relief- Dog Allergy Chews- Dog Itch Relief - Dog Skin Allergy Relief - Lamb - 90ct
Main highlights

Supports Immunity and Digestion
Zesty Paws Aller-Immune Bites enhance immunity, digestion, and skin health with EpiCor and probiotics.

Ideal for Allergy-Prone Dogs
Best for dogs with seasonal allergies and sensitive skin, providing relief from itching and irritation.

Praised for Allergy Relief
Highly rated for reducing allergy symptoms and improving coat condition in dogs.
Key specs
- Active Ingredients:EpiCor Pets, Colostrum
- Application Method:Oral
- Formulation:Chewables
- Target Area:Immune, Skin, Gut
- Relief Type:Dog Itch Remedies
9.5

Excellent

Our Rating

9.5
Gentle

9.3
Flavor

8.9
worth the money
4

Zesty Paws
Zesty Paws Probiotics for Dogs - Digestive Enzymes for Gut Flora, Digestive Health, Diarrhea & Bowel Support - Clinically Studied DE111 - Dog Supplement Soft Chew for Pet Immune System - Pumpkin
Main highlights

Digestive and Immune Support
Contains DE111 probiotic and six-strain blend for gut health.

For All Dog Breeds
Ideal for small, medium, and large dogs needing digestive aid.

Reduces Gas and Bloating
Praised for eliminating unpleasant odors and digestive discomfort.
9.2

Excellent

Our Rating

9.9
Gentle

9.7
Comfort

9.3
worth the money
5

VETIQ
VetIQ Multivitamin Supplement for Dogs, Supports Active Brain Function, Immune System, and Digestive System, Hickory Smoke Flavored Dog Multivitamin, Made in The USA, 60 Count

14% Off
Main highlights

Comprehensive Health Support
VetIQ Multivitamin aids brain, immune, and digestive systems.

Ideal for Training and Anxiety
Perfect for training and calming anxious dogs.

Highly Praised Flavor and Texture
Dogs love the hickory smoke flavor and soft chew texture.
Key specs
- Formulation:Multivitamin
- Dimensions:1.5 x 6.18 x 7.75 inches
- Health Benefit:Supports brain, immune, digestive
- Country of Origin:USA
- Ingredients:N/A
9.1

Excellent

Our Rating

8.0
Flavor

8.0
Simple to use

8.0
worth the money
See Today’s Deals & Prices
6

Zesty Paws
Zesty Paws Dog Multivitamin, Chewable Dog Vitamins and Supplements for Hip & Joints, Skin & Coat, Omega 3 Fish Oil for Dogs- Senior & Puppy Multivitamin- Chicken- 90ct
Main highlights

8-in-1 Formula Benefits
Comprehensive support for joints, skin, heart, immune, liver, and gut health.

Ideal for Dogs with Joint Issues
Perfect for senior dogs needing joint and skin support.

Praised for Skin and Coat Improvement
Significantly reduces shedding and enhances coat shine.
9.0

Excellent

Our Rating

9.3
worth the money

9.3
quality of ingredients

9.1
Flavor
7

VOSIFSDIY

Dog Multivitamin,15 in 1 Dog Multivitamin Liquid Drops Supplements, Dog Vitamins for Heart Health, Bones, Joint, Skin & Coat, Bladder, Immune System Support 60ml

24% Off
8.8

Very Good

Our Rating
8

Standard Process Inc.

Standard Process Canine Immune System Support - Immune Support Supplement for Dogs - Powder Canine Supplement Aids Overall Health & Wellness - Immunity Support Supplement with Zinc & Kelp - 30 g
8.6

Very Good

Our Rating
9

NaturVet

NaturVet Mushroom Max Advanced Immune Support Dog Supplement – Helps Strengthen Immunity, Overall Health for Dogs – Includes Shitake Mushrooms, Reishi, Turkey Tail – 60 Ct.
8.5

Good

Our Rating

9.1
Simple to use

8.9
worth the money

8.2
Flavor
10

NaturVet
NaturVet Senior Advanced 5-in-1 Support Dog Supplement – Helps Support Immune System, Heart, Liver, Cognitive Function, Eye Health – Includes Ginkgo Biloba, Lutein – 60 Ct.
Main highlights

Key Features
Blend of ginkgo biloba, lutein, milk thistle, CoQ10 to support overall health, immune system, and liver, eye, heart functions in dogs.

Ideal Use Cases
Perfect for aging dogs needing immune, cognitive, and organ support; enhances activity and comfort with flavorful, easy-to-digest soft chew supplements.

Customer Praise
Most reviews highlight the noticeable improvement in their dogs` energy and health after regular use, appreciating its effectiveness and great taste.
Key specs
- Formulation:Soft chew
- Dimensions:4.92 x 2.83 x 2.72 inches
- Health Benefit:Supports overall health
- Country of Origin:USA
- Ingredients:Ginkgo biloba, lutein, milk thistle, coenzyme Q10
8.4

Good

Our Rating

8.2
worth the money

8.0
Flavor

8.0
quality of ingredients

10 Best immune system supplements for dogs of 2025

1

Critical Immune Defense for Dogs & Cats; Supports Normal Cell Growth - Turkey Tail, Reishi, Shiitake and Maitake Mushroom Formula with Patented White Turmeric Root Extract - 30-Day Supply

8.2

8.2

8.2

How do we rank?

How do we rank?

Analyzing top stores

2

Wuffes 23-in-1 Dog Multivitamin Supplement for Hip & Joint, Skin & Coat and Immune System Support with Omega 3, Iron, Zinc, Vitamin C - Minerals & Vitamins for Senior Dogs and Puppies - 30 Soft Chews

8.4

8.0

8.0

3

Zesty Paws Dog Allergy Relief- Dog Itching Skin Relief- Dog Probiotics for Itchy Skin and Itchy Ears- Dog Allergy Paw Relief- Dog Allergy Chews- Dog Itch Relief - Dog Skin Allergy Relief - Lamb - 90ct

9.5

9.3

8.9

4

Zesty Paws Probiotics for Dogs - Digestive Enzymes for Gut Flora, Digestive Health, Diarrhea & Bowel Support - Clinically Studied DE111 - Dog Supplement Soft Chew for Pet Immune System - Pumpkin

9.9

9.7

9.3

5

VetIQ Multivitamin Supplement for Dogs, Supports Active Brain Function, Immune System, and Digestive System, Hickory Smoke Flavored Dog Multivitamin, Made in The USA, 60 Count

8.0

8.0

8.0

6

Zesty Paws Dog Multivitamin, Chewable Dog Vitamins and Supplements for Hip & Joints, Skin & Coat, Omega 3 Fish Oil for Dogs- Senior & Puppy Multivitamin- Chicken- 90ct

9.3

9.3

9.1

7

Dog Multivitamin,15 in 1 Dog Multivitamin Liquid Drops Supplements, Dog Vitamins for Heart Health, Bones, Joint, Skin & Coat, Bladder, Immune System Support 60ml

8

Standard Process Canine Immune System Support - Immune Support Supplement for Dogs - Powder Canine Supplement Aids Overall Health & Wellness - Immunity Support Supplement with Zinc & Kelp - 30 g

9

NaturVet Mushroom Max Advanced Immune Support Dog Supplement – Helps Strengthen Immunity, Overall Health for Dogs – Includes Shitake Mushrooms, Reishi, Turkey Tail – 60 Ct.

9.1

8.9

8.2

10

NaturVet Senior Advanced 5-in-1 Support Dog Supplement – Helps Support Immune System, Heart, Liver, Cognitive Function, Eye Health – Includes Ginkgo Biloba, Lutein – 60 Ct.

8.2

8.0

8.0

Sign up and get exclusive special deals