10 Best histamine supplements of 2025

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Best Choice

1

HEART & SOIL
HEART & SOIL Histamine and Immune Support – 3000mg DAO Enzyme Supplements with Bovine Thymus, Selenium & Vitamin A – Non-GMO, Allergen-Free – 180 Capsules
Main highlights

Rich in Nutrient-Dense Organs
Our immune support supplement is rich in grass-fed thymus, lung, spleen, liver, and kidney, providing comprehensive immune system support.

Ideal for Immune System Boost
Perfect for those looking to enhance their immune defense, manage histamine intolerance, and support overall wellness with natural, additive-free ingredients.

Highly Praised for Energy Boost
Customers rave about the instant and long-lasting energy boost, improved allergy symptoms, and overall better immune function after using this supplement.
Key specs
- Capsules:Six daily
- Form:Capsules
- Ingredients:Thymus, lung, spleen, liver, kidney
- Benefits:Immune system support
- Serving Size:Six capsules daily
9.9

Exceptional

Our Rating

9.9
quality of ingredients

9.7
worth the money

9.3
simple to consume
How do we rank?

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Value for Money

2

Pure Encapsulations

Pure Encapsulations Hist Reset | Support for Nasal and Respiratory Health* | 120 Capsules
9.8

Exceptional

Our Rating
3

Seeking Health
Seeking Health Histamine Digest - Formerly Histamine Block, DAO Enzyme Supplement for Histamine Food Intolerance, Supports Digestive Health, Upset Stomach, Vegetarian (30 Capsules)*
Main highlights

Digestive Health Support
Histamine Digest helps manage histamine intolerance by providing DAO enzyme support for better digestion and relief from symptoms like gas and bloating.

Ideal for Histamine Intolerance
Designed for those experiencing histamine intolerance, particularly useful before consuming histamine-rich foods and drinks.

Customer Praised Effectiveness
Highly appreciated for its effectiveness in reducing symptoms like hives and allergies, offering significant relief to users.
9.7

Exceptional

Our Rating

9.5
simple to consume

8.9
Flavor

8.0
worth the money
4

Bravado Labs

Bravado Labs DAO Supplements Histamine Blocker – Extra Potent 30,000 HDU DAO Enzyme Formula for Histamine Digest & Immune Support – for Food-Related Histamine Intolerance - Daily Use - 120 caps.
9.4

Excellent

Our Rating
5

Seeking Health

Seeking Health HistaminX, Histamine Support with Bioflavonoids, Natural Nettle, Quercetin, Rutin, Bromelain, for Immune System and Inflammation Support, Seasonal Support, Vegetarian (60 Capsules)
9.2

Excellent

Our Rating
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6

Prodigy Life
Premium Histamine Block Supplement
Main highlights

Histamine Regulation Support
Premium capsules with Diamine Oxidase enzyme to reduce food-derived histamine intolerance.

Ideal for Histamine Sensitivity
Best for individuals with low DAO levels or food allergies.

Affordable and Effective
Praised for being a budget-friendly option without compromising quality.
Key specs
- Capsules:30
- Form:Capsule
- Ingredients:Powerful ingredients, non-GMO
- Benefits:Healthy digestion, immunity
- Serving Size:One capsule
9.0

Excellent

Our Rating

9.9
simple to consume

9.5
worth the money

9.3
Flavor
7

Nature's Sunshine
Nature's Sunshine HistaBlock | Respiratory Support Supplement | Supports Airways & Blocks Irritants | Antioxidant Strength | Seasonal Allergy Help | Natural Respiratory Function Aid 90 Capsules

12% Off
Main highlights

Key Features
Combines bromelain, stinging nettle, and bitter orange for natural sinus relief, reducing mucous membrane swelling and supporting open airways.

Ideal Use Cases
Perfect for those experiencing seasonal allergies or respiratory stress, aiming for relief against airborne irritants, pollutants, and toxins.

Customer Reviews
Most praised for its effectiveness in providing rapid and noticeable relief from sinus and respiratory discomfort, with natural ingredients highlighted.
8.8

Very Good

Our Rating

9.7
simple to consume

9.1
Flavor

8.9
worth the money
8

Histamine Shield Plus
Histamine Shield Plus™ Natural Antihistamine Supplement for Adults, Sinus & Allergy Relief for Pollen, Pet Dander, Dust, Mold, and Odors, Quercetin with Bromelain & Stinging Nettle 120 Capsules
Main highlights

Natural Allergy Relief
Utilizes naturally occurring ingredients to potentially relieve allergy symptoms and minimize side effects.

Versatile Use Cases
Ideal for managing allergies from pet dander, pollen, dust, and mold.

Highly Praised Absorption
Customers appreciate the fast absorption and effectiveness of the natural vegetable capsules.
Key specs
- Manufacturer:WellSource Nutraceuticals
- Country of Origin:USA
- Battery Life:N/A
- Screen Size:N/A
- RAM Size:N/A
8.6

Very Good

Our Rating
9

Ancestral Supplements
Ancestral Supplements Grass Fed Beef Kidney Supplement, 3000mg, DAO Enzyme Supplement, Kidney Support for Urinary and Histamine Health, Selenium, B12, Non GMO, 180 Capsules
Main highlights

Rich Kidney Nutrients
Contains proteins, peptides, and enzymes for kidney health.

Histamine Intolerance Aid
Supports healthy histamine levels with DAO, B12, Selenium.

Exceptional Customer Service
Customers praise responsive and helpful support from Brian.
Key specs
- Origin:New Zealand, Australia
- Usage:Kidney health support
- Form:Capsule
- Enzyme Blend:Diamine oxidase DAO
- Dietary Restrictions:No GMOs, fillers
8.5

Good

Our Rating

9.9
quality of ingredients

9.7
Support

9.7
Flavor
10

NATURALABS

NATURALABS DAO Supplements Histamine Blocker – Enzyme+ Diamine Oxidase & Vitamin C for Gut Health & Food Support – 60 Servings - 1 Capsule Before Meals for Histamine Intolerance
8.3

Good

Our Rating

10 Best histamine supplements of 2025

1

HEART & SOIL Histamine and Immune Support – 3000mg DAO Enzyme Supplements with Bovine Thymus, Selenium & Vitamin A – Non-GMO, Allergen-Free – 180 Capsules

9.9

9.7

9.3

How do we rank?

How do we rank?

Analyzing top stores

2

Pure Encapsulations Hist Reset | Support for Nasal and Respiratory Health* | 120 Capsules

3

Seeking Health Histamine Digest - Formerly Histamine Block, DAO Enzyme Supplement for Histamine Food Intolerance, Supports Digestive Health, Upset Stomach, Vegetarian (30 Capsules)*

9.5

8.9

8.0

4

Bravado Labs DAO Supplements Histamine Blocker – Extra Potent 30,000 HDU DAO Enzyme Formula for Histamine Digest & Immune Support – for Food-Related Histamine Intolerance - Daily Use - 120 caps.

5

Seeking Health HistaminX, Histamine Support with Bioflavonoids, Natural Nettle, Quercetin, Rutin, Bromelain, for Immune System and Inflammation Support, Seasonal Support, Vegetarian (60 Capsules)

6

Premium Histamine Block Supplement

9.9

9.5

9.3

7

Nature's Sunshine HistaBlock | Respiratory Support Supplement | Supports Airways & Blocks Irritants | Antioxidant Strength | Seasonal Allergy Help | Natural Respiratory Function Aid 90 Capsules

9.7

9.1

8.9

8

Histamine Shield Plus™ Natural Antihistamine Supplement for Adults, Sinus & Allergy Relief for Pollen, Pet Dander, Dust, Mold, and Odors, Quercetin with Bromelain & Stinging Nettle 120 Capsules

9

Ancestral Supplements Grass Fed Beef Kidney Supplement, 3000mg, DAO Enzyme Supplement, Kidney Support for Urinary and Histamine Health, Selenium, B12, Non GMO, 180 Capsules

9.9

9.7

9.7

10

NATURALABS DAO Supplements Histamine Blocker – Enzyme+ Diamine Oxidase & Vitamin C for Gut Health & Food Support – 60 Servings - 1 Capsule Before Meals for Histamine Intolerance

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