10 Best eye ointments of 2025

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Best Choice

1

Systane
Systane Lub Eye Nightime Ointment 3.5g (6 Pack) 0.12 Ounce(Packaging May Vary)
Main highlights

Effective for Severe Dry Eyes
Contains 94% White Petrolatum and 3% Mineral Oil, providing long-lasting moisture and relief for extremely dry eyes. Ideal for nighttime use.

Ideal for Post-Eye Surgery Care
Perfect for individuals recovering from eye surgery or those with severe dry eyes. Provides overnight protection and moisture, ensuring comfort and healing.

Highly Praised for Long-Lasting Comfort
Customers appreciate the thick consistency and effectiveness, noting significant relief from dry eyes and improved comfort throughout the night.
9.9

Exceptional

Our Rating

9.5
Moisturizing

9.3
Simple to use

8.7
worth the money
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Value for Money

2

RUGBY LABORATORIES

Rugby Sodium Chloride Hypertonicity Ophthalmic Ointment 5% - 50 mg Sodium Chloride Eye Ointment for Temporary Corneal Edema Relief - Made With Lanolin and Mineral Oil - Alcohol-Free - 0.125 Oz(3 Pack)
9.8

Exceptional

Our Rating
3

Systane
Systane Nighttime Lubricant Eye Ointment 3.5g Tube
Main highlights

Long-Lasting Protection
Forms a long-lasting, protective layer on eyes while you sleep, soothing and protecting against dryness and irritation.

Ideal for Nighttime Use
Best used for nighttime relief of dry eye symptoms, providing comfort and protection as you rest.

Soothing Effect
Most praised for its soothing effect, alleviating discomfort from dry eyes effectively.
Key specs
- Formula:Preservative-free
- Usage:Nighttime
- Preservatives:None
- Hydration:Soothes and protects
- Application:Nighttime relief for dry eyes
9.6

Exceptional

Our Rating
4

Soothe
Soothe Preservative-Free Lubricant Eye Ointment, Nighttime Relief for Severe Dry & Irritated Eyes, Gentle for Sensitive Eyes, 0.12 Fl Oz

20% Off
Main highlights

Key Features and Benefits
Moisturizes and refreshes severe dry eyes overnight with a soothing formula, containing two lubricants for long-lasting relief and comfort.

Ideal Use Cases
Perfect for individuals suffering from severe dry eyes, especially effective overnight to prevent irritation and provide relief from dryness.

Customer Reviews Highlight
Most reviews praise its effectiveness in providing significant relief from severe dryness, noting its ease of use and overnight comfort.
9.4

Excellent

Our Rating

8.2
worth the money

8.0
Simple to use
5

OCuSOFT
OCuSOFT Retaine PM Nighttime Ointment - Lubricant Eye Ointment for Overnight Dry Eye Comfort - Cools and Soothes Irritated Eyes - 5g Tube

18% Off
Main highlights

Overnight Dry Eye Relief
Designed to keep eyes lubricated and comfortable while you sleep, this easy-to-use ointment is preservative-free and made in the USA.

Best for Nighttime Use
Ideal for those with chronic dry eyes, cornea tears, or exposure to dry environments. Recommended by ophthalmologists for overnight relief.

Customer Praise for Long-lasting Moisture
Users appreciate the long-lasting moisture and relief it provides, noting significant improvements in eye comfort and reduced dryness.
Key specs
- Formula:Preservative-Free Oil Based
- Usage:Nighttime use only
- Preservatives:Preservative-Free
- Hydration:Seals in Moisture
- Application:Overnight Dry Eye Relief
9.3

Excellent

Our Rating

9.3
Moisturizing

8.7
Simple to use

8.2
worth the money
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6

Genteal
Genteal Tears Night-Time Ointment 3.5g Clear 0.12 Fl Oz
Main highlights

Severe Dry Eye Symptom Relief
Provides long-lasting nighttime relief, moisturizes and lubricates eyes, and protects against further eye irritation.

Nighttime Use for Maximum Effectiveness
Ideal for severe dry eyes, Bell's Palsy, Sjogren syndrome, and post-eye surgery care. Apply before bed for best results.

Thick and Soothing Formula
Praised for its thick, soothing consistency that provides overnight comfort and prevents eye irritation and dryness.
9.2

Excellent

Our Rating

9.9
Moisturizing

9.3
worth the money

8.0
Simple to use
7

Stye
Stye Sterile Lubricant Eye Ointment, Ophthalmologist Tested, 0.125 ounces (Pack of 1)
Main highlights

Dual-Action Relief and Lubrication
Provides symptomatic stye relief and lubrication to prevent further irritation.

Ideal for Stye Treatment
Perfect for relieving discomfort from styes, including burning and itching.

Trusted Stye Relief
Praised for easing pain with quick, effective results.
Key specs
- Use Case:Stye treatment relief
- Relief Duration:Temporarily relieves discomfort
- Eye Comfort:Relieves burning, stinging, itching
- Moisturizing Formula:Dual-action formula
- Preservative Free:N/A
9.0

Excellent

Our Rating

8.0
Comfort

8.0
Simple to use

8.0
worth the money
8

Optase
Optase HYLO Night Eye Ointment - .18 oz

15% Off
Main highlights

Preservative Free Night Relief
OPTASE Hylo Night Ointment provides comfortable lubrication for dry eye relief, free from preservatives.

Ideal for Nighttime Use
Designed for overnight application to protect and lubricate eyes while sleeping.

Effective Dry Eye Relief
Customers praise its effectiveness in reducing morning dry-eye symptoms and protecting the cornea.
Key specs
- Formula:White Petrolatum, Lanolin, Light Mineral Oil
- Usage:Apply before bed
- Preservatives:Preservative free
- Hydration:Over 6 hours retention
- Application:Nighttime dry eye relief
8.9

Very Good

Our Rating

9.7
Moisturizing

9.3
Comfort

8.0
Simple to use
9

Systane

Systane Nighttime Lubricant Eye Ointment 3.50 g , 0.12 Oz (Pack of 3)

20% Off
8.8

Very Good

Our Rating
10

Genteal
GenTeal Tears Lubricant Eye Ointment, Night-Time Ointment, 0.12 Fl Oz (Pack of 3)
Main highlights

Night-time Dry Eye Relief
Concentrated ointment formula offering long-lasting comfort, free from preservatives and lanolin, ideal for overnight use to alleviate dry eye symptoms.

Best for Severe Dry Eye Cases
Highly effective for individuals with severe dry eye conditions, partial facial paralysis, or those needing intense overnight lubrication.

Most Praised Feature
Highly effective overnight eye lubricant providing consistent relief; customers appreciate its ability to maintain eye moisture throughout the night.
Key specs
- Use Case:Night-time use
- Relief Duration:Long lasting night-time
- Eye Comfort:Night-time dry eye relief
- Moisturizing Formula:Concentrated ointment
- Preservative Free:Yes
8.7

Very Good

Our Rating

9.3
Moisturizing

8.0
Simple to use

8.0
worth the money

10 Best eye ointments of 2025

1

Systane Lub Eye Nightime Ointment 3.5g (6 Pack) 0.12 Ounce(Packaging May Vary)

9.5

9.3

8.7

How do we rank?

How do we rank?

Analyzing top stores

2

Rugby Sodium Chloride Hypertonicity Ophthalmic Ointment 5% - 50 mg Sodium Chloride Eye Ointment for Temporary Corneal Edema Relief - Made With Lanolin and Mineral Oil - Alcohol-Free - 0.125 Oz(3 Pack)

3

Systane Nighttime Lubricant Eye Ointment 3.5g Tube

4

Soothe Preservative-Free Lubricant Eye Ointment, Nighttime Relief for Severe Dry & Irritated Eyes, Gentle for Sensitive Eyes, 0.12 Fl Oz

8.2

8.0

5

OCuSOFT Retaine PM Nighttime Ointment - Lubricant Eye Ointment for Overnight Dry Eye Comfort - Cools and Soothes Irritated Eyes - 5g Tube

9.3

8.7

8.2

6

Genteal Tears Night-Time Ointment 3.5g Clear 0.12 Fl Oz

9.9

9.3

8.0

7

Stye Sterile Lubricant Eye Ointment, Ophthalmologist Tested, 0.125 ounces (Pack of 1)

8.0

8.0

8.0

8

Optase HYLO Night Eye Ointment - .18 oz

9.7

9.3

8.0

9

Systane Nighttime Lubricant Eye Ointment 3.50 g , 0.12 Oz (Pack of 3)

10

GenTeal Tears Lubricant Eye Ointment, Night-Time Ointment, 0.12 Fl Oz (Pack of 3)

9.3

8.0

8.0

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