November 3, 2025

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10 Best enzyme urine cleaners of 2025

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1

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Rocco & Roxie Supply Co.
Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray, 1-Gallon
Main highlights

Certified Safe and Effective
Chlorine-free, color-safe formula certified by Carpet and Rug Institute.

Ideal for Pet-Related Stains
Perfect for eliminating pet urine, feces, vomit, and organic spills.

Highly Praised Odor Elimination
Customers rave about its miraculous ability to remove odors completely.
Key specs
- Formula:Enzyme Activated
- Use:Eliminate Stains, Odors
- Stain Type:Pet urine, feces, vomit
- Packaging:1-gallon
- Safety:Chlorine free, color safe
9.7

Exceptional

Our Rating

9.9
worth the money

9.5
Simple to use

8.9
Odor elimination
How do we rank?

Powerful technology We scan thousands of products and stores, analyzing reviews to find what matters most to users like you

Careful review Our team ensures quality, value, and fit based on real user feedback

Trusted insights AI and human analysis guide your decisions, reflecting real user priorities
Real users impact

Thousands of users trust our site daily

Based on millions of stores and reviews

Shoppers influence our rankings
Analyzing top stores
Value for Money

2

Biokleen
Biokleen Bac-Out Enzyme Stain & Odor Remover - 128 Ounces - Destroys Stains & Odors Safely, for Pet Stains, Laundry, Diapers, Wine, Carpets, & More, Eco-Friendly, Non-Toxic
Main highlights

Eco-Friendly Formula
Bac-Out uses a plant-based, biodegradable formula without harsh chemicals.

Versatile Cleaning Use
Ideal for pet accidents, laundry, carpets, and more.

Effective Odor Removal
Customers praise its ability to eliminate odors effectively.
9.6

Exceptional

Our Rating

9.7
Simple to use

9.5
Aroma

9.5
Odor elimination
3

Bioda
Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon
Main highlights

Powerful Cleaning and Odor Control
This probiotic cleaner offers powerful cleaning and odor elimination for various surfaces, leaving a fresh lemon and sage scent.

Ideal for Pet and Household Use
Perfect for managing pet stains, odors, and maintaining household cleanliness, especially in bathrooms and kitchens.

Highly Effective Odor Elimination
Customers praise its ability to permanently eliminate tough odors, especially from pet-related incidents and organic waste.
Key specs
- volume:1 Gallon
- cleaning method:Probiotic cleaner
- scent:Lemon and sage
- specific instructions:Spray & let probiotics work
- perfume:Lemon and sage
9.5

Excellent

Our Rating
4

Rocco & Roxie Supply Co.
Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray Clear, 32 Fl Oz
Main highlights

Certified Safe and Effective
Chlorine-free, color-safe, and CRI-approved for all carpets.

Ideal for Pet Owners
Perfect for removing pet stains and odors from multiple surfaces.

Enzyme-Based Miracle Worker
Customer reviews praise its ability to eliminate odors completely.
Key specs
- Formula:Enzyme Activated
- Use:Stain, Odor Removal
- Stain Type:Urine, Feces, Vomit
- Packaging:Spray
- Safety:Chlorine free, Safe for pets
9.4

Excellent

Our Rating

9.9
worth the money

9.5
Simple to use

8.9
Odor elimination
5

Nature's Miracle
Nature’s Miracle Urine Destroyer Plus Cat, 32 Ounces, Enzymatic Formula, Ready-to-Use
Main highlights

Powerful Stain and Odor Removal
Enzymatic formula breaks down severe cat urine stains and odors.

Ideal for Persistent Pet Messes
Perfect for cleaning carpets, furniture, and litter box areas.

Highly Effective Odor Control
Praised for eliminating smells, preventing repeat pet marking.
Key specs
- Formula:Enzymatic
- Use:Cat urine messes
- Stain Type:Bio-based mess
- Packaging:2.29 Pounds
- Safety:Safe for pets
9.2

Excellent

Our Rating

9.7
Freshness

9.3
Simple to use

8.4
worth the money
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6

Resolve
Resolve Urine Destroyer Spray – Pet Stain and Odor Remover, Carpet Cleaner Solution for Cat and Dog Urine, 32 Fl Oz

33% Off
Main highlights

Odor Neutralization and Stain Removal
Neutralizes odors on contact and removes pet and food stains.

Ideal for Households with Pets and Kids
Perfect for carpets, fabrics, and hard surfaces in busy homes.

Customer Praise for Odor Elimination
Praised for effectively reducing odors, even with repeated use.
Key specs
- odor removal:Neutralizes & destroys odors
- surface compatibility:Carpets, fabrics, hard surfaces
- volume:N/A
- active ingredients:N/A
- scent:N/A
9.1

Excellent

Our Rating

9.5
Simple to use

9.1
worth the money

8.7
Aroma
7

Zep

Zep Urine Remover 128 Ounces Targets and Eliminates Urine Odors and Stains
8.8

Very Good

Our Rating
8

Nature's Miracle
Nature’s Miracle Urine Destroyer Plus Dog, 32 Ounces, Enzymatic Formula, Ready-to-Use
Main highlights

Powerful_Enzymatic_Cleaning
Begins breaking down stains immediately and continues until bio-mess is gone.

Versatile_Use_Scenarios
Ideal for multi-pet households, effective on carpets, floors, and fabrics.

Customer_Praised_Sprayer
Battery-powered sprayer offers ease and precision in application.
Key specs
- Enzymatic Formula:Continues working on bio-mess
- Usage:Dog urine messes
- Dimensions:10.51 x 4.61 x 2.76 inches
- Features:Safe for pets and home
- Odor Control:Breaks down odor
8.6

Very Good

Our Rating

9.7
potty training

8.9
Odor elimination

8.7
Simple to use
9

AmazonCommercial
AmazonCommercial Multi-Purpose Enzyme Cleaner, 1-Gallon, 1-Pack
Main highlights

Powerful Enzymatic Cleaning
Breaks down complex organic proteins, pet stains, and odors on various surfaces.

Ideal for Pet Owners
Perfect for homes with pets, tackling messes on carpets, furniture, and more.

Highly Praised Odor Elimination
Customers love its ability to eliminate odors, not just mask them.
8.5

Good

Our Rating

9.3
Simple to use

9.1
worth the money

8.9
Odor elimination
10

KINZUA ENVIRONMENTAL
KINZUA ENVIRONMENTAL Urine B-Gone, Professional Enzyme Odor Eliminator & Pet Stain Remover, Human, Cat & Dog Urine Cleaner, Effective on Laundry, Carpets & More, Original Scent, 1 Gallon
Main highlights

High Enzyme Count for Effective Cleaning
Contains over 200 billion enzymes to liquefy, digest, and eliminate urine and feces.

Versatile Applications for Pet Owners
Ideal for carpets, upholstery, laundry, drains, and toilets; perfect for households with pets.

Customer Praised Stain and Odor Removal
Highly effective in removing pet stains and odors, leaving carpets smelling fresh.
8.2

Good

Our Rating

9.1
Simple to use

8.9
Odor elimination

8.4
Aroma

10 Best enzyme urine cleaners of 2025

1

Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray, 1-Gallon

9.9

9.5

8.9

How do we rank?

How do we rank?

Analyzing top stores

2

Biokleen Bac-Out Enzyme Stain & Odor Remover - 128 Ounces - Destroys Stains & Odors Safely, for Pet Stains, Laundry, Diapers, Wine, Carpets, & More, Eco-Friendly, Non-Toxic

9.7

9.5

9.5

3

Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon

4

Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray Clear, 32 Fl Oz

9.9

9.5

8.9

5

Nature’s Miracle Urine Destroyer Plus Cat, 32 Ounces, Enzymatic Formula, Ready-to-Use

9.7

9.3

8.4

6

Resolve Urine Destroyer Spray – Pet Stain and Odor Remover, Carpet Cleaner Solution for Cat and Dog Urine, 32 Fl Oz

9.5

9.1

8.7

7

Zep Urine Remover 128 Ounces Targets and Eliminates Urine Odors and Stains

8

Nature’s Miracle Urine Destroyer Plus Dog, 32 Ounces, Enzymatic Formula, Ready-to-Use

9.7

8.9

8.7

9

AmazonCommercial Multi-Purpose Enzyme Cleaner, 1-Gallon, 1-Pack

9.3

9.1

8.9

10

KINZUA ENVIRONMENTAL Urine B-Gone, Professional Enzyme Odor Eliminator & Pet Stain Remover, Human, Cat & Dog Urine Cleaner, Effective on Laundry, Carpets & More, Original Scent, 1 Gallon

9.1

8.9

8.4

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