September 13, 2025

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10 Best enzyme urine cleaners of 2025

Save up to 27% off

Best Choice

1

Black Diamond Stoneworks

Commercial Multi-Purpose Enzyme Cleaner & Odor Eliminator | Pet & Human Urine, Stains & Odors | Carpet, Laundry, Bathroom, Drain & Trash Deodorizer | Dog, Cat, Organic Waste Remover (1 Gallon)
9.9

Exceptional

Our Rating
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Value for Money

2

Biokleen
Biokleen Bac-Out Enzyme Stain & Odor Remover - 128 Ounces - Destroys Stains & Odors Safely, for Pet Stains, Laundry, Diapers, Wine, Carpets, & More, Eco-Friendly, Non-Toxic
Main highlights

Eco-Friendly Formula
Bac-Out uses a plant-based, biodegradable formula without harsh chemicals.

Versatile Cleaning Use
Ideal for pet accidents, laundry, carpets, and more.

Effective Odor Removal
Customers praise its ability to eliminate odors effectively.
9.8

Exceptional

Our Rating

9.7
Simple to use

9.5
Aroma

9.5
Odor elimination
3

Rocco & Roxie Supply Co.
Rocco & Roxie Stain & Odor Eliminator for Strong Odor, 32oz Enzyme Pet Odor Eliminator for Home, Carpet Stain Remover for Cats & Dog Pee, Enzymatic Cat Urine Destroyer, Carpet Cleaner Spray

27% Off
Main highlights

Certified Safe and Effective
Chlorine-free, color-safe, and CRI-approved for all carpets.

Ideal for Pet Owners
Perfect for removing pet stains and odors from multiple surfaces.

Enzyme-Based Miracle Worker
Customer reviews praise its ability to eliminate odors completely.
Key specs
- Formula:Enzyme Activated
- Use:Stain, Odor Removal
- Stain Type:Urine, Feces, Vomit
- Packaging:Spray
- Safety:Chlorine free, Safe for pets
9.7

Exceptional

Our Rating

9.9
worth the money

9.5
Simple to use

8.9
Odor elimination
4

Bioda
Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon
Main highlights

Powerful Cleaning and Odor Control
This probiotic cleaner offers powerful cleaning and odor elimination for various surfaces, leaving a fresh lemon and sage scent.

Ideal for Pet and Household Use
Perfect for managing pet stains, odors, and maintaining household cleanliness, especially in bathrooms and kitchens.

Highly Effective Odor Elimination
Customers praise its ability to permanently eliminate tough odors, especially from pet-related incidents and organic waste.
Key specs
- volume:1 Gallon
- cleaning method:Probiotic cleaner
- scent:Lemon and sage
- specific instructions:Spray & let probiotics work
- perfume:Lemon and sage
9.6

Exceptional

Our Rating
5

Nature's Miracle
Nature’s Miracle Urine Destroyer Plus Dog, 32 Ounces, Enzymatic Formula, Ready-to-Use
Main highlights

Powerful_Enzymatic_Cleaning
Begins breaking down stains immediately and continues until bio-mess is gone.

Versatile_Use_Scenarios
Ideal for multi-pet households, effective on carpets, floors, and fabrics.

Customer_Praised_Sprayer
Battery-powered sprayer offers ease and precision in application.
Key specs
- Enzymatic Formula:Continues working on bio-mess
- Usage:Dog urine messes
- Dimensions:10.51 x 4.61 x 2.76 inches
- Features:Safe for pets and home
- Odor Control:Breaks down odor
9.4

Excellent

Our Rating

9.7
potty training

8.9
Odor elimination

8.7
Simple to use
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6

KINZUA ENVIRONMENTAL
KINZUA ENVIRONMENTAL Urine B-Gone, Professional Enzyme Odor Eliminator & Pet Stain Remover, Human, Cat & Dog Urine Cleaner, Effective on Laundry, Carpets & More, Original Scent, 1 Gallon
Main highlights

High Enzyme Count for Effective Cleaning
Contains over 200 billion enzymes to liquefy, digest, and eliminate urine and feces.

Versatile Applications for Pet Owners
Ideal for carpets, upholstery, laundry, drains, and toilets; perfect for households with pets.

Customer Praised Stain and Odor Removal
Highly effective in removing pet stains and odors, leaving carpets smelling fresh.
9.1

Excellent

Our Rating

9.1
Simple to use

8.9
Odor elimination

8.4
Aroma
7

Resolve
Resolve Urine Destroyer Spray – Pet Stain and Odor Remover, Carpet Cleaner Solution for Cat and Dog Urine, 32 Fl Oz
Main highlights

Odor Neutralization and Stain Removal
Neutralizes odors on contact and removes pet and food stains.

Ideal for Households with Pets and Kids
Perfect for carpets, fabrics, and hard surfaces in busy homes.

Customer Praise for Odor Elimination
Praised for effectively reducing odors, even with repeated use.
Key specs
- odor removal:Neutralizes & destroys odors
- surface compatibility:Carpets, fabrics, hard surfaces
- volume:N/A
- active ingredients:N/A
- scent:N/A
9.0

Excellent

Our Rating

9.5
Simple to use

9.1
worth the money

8.7
Aroma
8

Simple Solution
Simple Solution Extreme Pet Stain and Odor Eliminator Spray, Enzymatic Cleaner With 3X Pro-Bacteria Cleaning Power for Dogs & Cats, Strong Urine, Pee and Poop Smell Remover for Carpets & Floors, 32 oz
Main highlights

Powerful Enzymatic Formula
Three times stronger than regular formulas, effectively removes tough pet stains and odors.

Versatile Home Use
Ideal for cleaning dog and cat urine, feces, vomit on carpets, upholstery, and more.

Highly Praised Sprayer
Customers love the improved sprayer for its fine mist and no leakage.
8.9

Very Good

Our Rating

9.7
Odor elimination

9.3
Comfort

9.1
deep clean
9

KIDS 'N' PETS
KIDS 'N' PETS Instant All-Purpose Stain & Odor Remover Permanently Eliminates Dog Pee, Cat Urine, Other Smells, Spots from Home Carpet, Couch, Furniture, Mattress, Fabric. Non-Toxic, Child Safe - 27oz
Main highlights

Neutralizes Odors and Stains
Patented formula effectively neutralizes and eliminates tough odors and stains, ensuring a deep clean.

Versatile Application
Ideal for use on carpets, furniture, bedding, and any water-safe surfaces.

Highly Effective Odor Removal
Praised for exceptional ability to permanently eliminate urine and other odors.
Key specs
- Usage:Household stains & odors
- Formulation:Patented formula
- Surface Compatibility:Carpet, furniture, mattresses
- Stain Remover:Instant All-purpose
- Special Features:Non-Toxic & Cruelty-Free
8.8

Very Good

Our Rating

9.9
Stain resistance

9.5
Simple to use

9.1
worth the money
10

Nilodor
Nilodor BEON Urine Enzymatic Cleaner with Odor Neutralizer for Pet Dog, Carpet, and Bathroom, 1 Gallon, Cucumber Melon
Main highlights

Key Features
Bio-Enzymatic formula with odor neutralizer, works continuously, suitable for hard surfaces and carpets, and features a refreshing Cucumber Melon Fragrance.

Ideal Use Cases
Perfect for use around urinals, commodes, or any frequently soiled areas in homes, schools, or commercial settings. Effective on both hard surfaces and carpets.

Customer Praise
Most reviews highlight its effectiveness in odor elimination, leaving areas smelling fresh with the pleasant scent of Cucumber Melon being particularly appreciated.
Key specs
- Formula:Odor neutralizer
- Scent:Cucumber Melon
- Application:Mop or spray
- Cleaner:Bio-Enzymatic
- Surface:Hard surface or carpeting
8.6

Very Good

Our Rating

9.9
Simple to use

9.9
worth the money

9.3
Aroma

10 Best enzyme urine cleaners of 2025

1

Commercial Multi-Purpose Enzyme Cleaner & Odor Eliminator | Pet & Human Urine, Stains & Odors | Carpet, Laundry, Bathroom, Drain & Trash Deodorizer | Dog, Cat, Organic Waste Remover (1 Gallon)

How do we rank?

How do we rank?

Analyzing top stores

2

Biokleen Bac-Out Enzyme Stain & Odor Remover - 128 Ounces - Destroys Stains & Odors Safely, for Pet Stains, Laundry, Diapers, Wine, Carpets, & More, Eco-Friendly, Non-Toxic

9.7

9.5

9.5

3

Rocco & Roxie Stain & Odor Eliminator for Strong Odor, 32oz Enzyme Pet Odor Eliminator for Home, Carpet Stain Remover for Cats & Dog Pee, Enzymatic Cat Urine Destroyer, Carpet Cleaner Spray

9.9

9.5

8.9

4

Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon

5

Nature’s Miracle Urine Destroyer Plus Dog, 32 Ounces, Enzymatic Formula, Ready-to-Use

9.7

8.9

8.7

6

KINZUA ENVIRONMENTAL Urine B-Gone, Professional Enzyme Odor Eliminator & Pet Stain Remover, Human, Cat & Dog Urine Cleaner, Effective on Laundry, Carpets & More, Original Scent, 1 Gallon

9.1

8.9

8.4

7

Resolve Urine Destroyer Spray – Pet Stain and Odor Remover, Carpet Cleaner Solution for Cat and Dog Urine, 32 Fl Oz

9.5

9.1

8.7

8

Simple Solution Extreme Pet Stain and Odor Eliminator Spray, Enzymatic Cleaner With 3X Pro-Bacteria Cleaning Power for Dogs & Cats, Strong Urine, Pee and Poop Smell Remover for Carpets & Floors, 32 oz

9.7

9.3

9.1

9

KIDS 'N' PETS Instant All-Purpose Stain & Odor Remover Permanently Eliminates Dog Pee, Cat Urine, Other Smells, Spots from Home Carpet, Couch, Furniture, Mattress, Fabric. Non-Toxic, Child Safe - 27oz

9.9

9.5

9.1

10

Nilodor BEON Urine Enzymatic Cleaner with Odor Neutralizer for Pet Dog, Carpet, and Bathroom, 1 Gallon, Cucumber Melon

9.9

9.9

9.3

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