10 Best enzyme cleaners of 2025

Save up to 20% off

Editor's Choice

1

Clicked 668 times in the last month

ANGRY ORANGE
Angry Orange Stain Remover - 32oz Enzyme Pet Cleaner - Dog & Cat Urine Destroyer and Stain Remover - Citrus Spray Cleaning Solution - Puppy Supplies
Main highlights

Dual Action Enzyme Cleaner
Combines stain removal and odor elimination for pet messes.

Versatile Multi-Surface Use
Ideal for carpets, hardwood, fabrics, and more.

Citrus Scented Success
Customers praise the effective odor removal and pleasant scent.
9.8

Exceptional

Our Rating

9.3
Simple to use

8.9
Aroma

8.7
Odor elimination
How do we rank?

Powerful technology We scan thousands of products and stores, analyzing reviews to find what matters most to users like you

Careful review Our team ensures quality, value, and fit based on real user feedback

Trusted insights AI and human analysis guide your decisions, reflecting real user priorities
Real users impact

Thousands of users trust our site daily

Based on millions of stores and reviews

Shoppers influence our rankings
Analyzing top stores
Value for Money

2

Biokleen
Biokleen Bac-Out Enzyme Stain & Odor Remover - 128 Ounces - Destroys Stains & Odors Safely, for Pet Stains, Laundry, Diapers, Wine, Carpets, & More, Eco-Friendly, Non-Toxic
Main highlights

Eco-Friendly Formula
Bac-Out uses a plant-based, biodegradable formula without harsh chemicals.

Versatile Cleaning Use
Ideal for pet accidents, laundry, carpets, and more.

Effective Odor Removal
Customers praise its ability to eliminate odors effectively.
9.7

Exceptional

Our Rating

9.7
Simple to use

9.5
Aroma

9.5
Odor elimination
3

GELEAN

Multi-Purpose Probiotic Enzyme Cleaner, Made in USA - Stain and Odor Remover - Concentrated - Professional & Home Strength Drains, Floors, Bathrooms, Toilets Trash Can, (128 Fl Oz, Fresh fragrance)
9.6

Exceptional

Our Rating
4

Rocco & Roxie Supply Co.
Rocco & Roxie Stain & Odor Eliminator for Strong Odor, 32oz Enzyme Pet Odor Eliminator for Home, Carpet Stain Remover for Cats & Dog Pee, Enzymatic Cat Urine Destroyer, Carpet Cleaner Spray

20% Off
Main highlights

Certified Safe and Effective
Chlorine-free, color-safe, and CRI-approved for all carpets.

Ideal for Pet Owners
Perfect for removing pet stains and odors from multiple surfaces.

Enzyme-Based Miracle Worker
Customer reviews praise its ability to eliminate odors completely.
Key specs
- Formula:Enzyme Activated
- Use:Stain, Odor Removal
- Stain Type:Urine, Feces, Vomit
- Packaging:Spray
- Safety:Chlorine free, Safe for pets
9.5

Excellent

Our Rating

9.9
worth the money

9.5
Simple to use

8.9
Odor elimination
5

Bioda
Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon
Main highlights

Powerful Cleaning and Odor Control
This probiotic cleaner offers powerful cleaning and odor elimination for various surfaces, leaving a fresh lemon and sage scent.

Ideal for Pet and Household Use
Perfect for managing pet stains, odors, and maintaining household cleanliness, especially in bathrooms and kitchens.

Highly Effective Odor Elimination
Customers praise its ability to permanently eliminate tough odors, especially from pet-related incidents and organic waste.
Key specs
- volume:1 Gallon
- cleaning method:Probiotic cleaner
- scent:Lemon and sage
- specific instructions:Spray & let probiotics work
- perfume:Lemon and sage
9.4

Excellent

Our Rating
See Today’s Deals & Prices
6

ACTIVE
Enzyme Laundry Booster Odor Remover - 2 lbs Unscented Enzymatic Clothes Stain Cleaner Powder, Natural Deodorizer with Bio Active Enzymes, Detergent Additive Eliminator for Sweat, Oil, Blood - 64 Loads
Main highlights

Effective Stain and Odor Removal
Bio enzymatic formula targets and eliminates tough stains and odors.

Perfect for Activewear and Pet Accidents
Ideal for removing sweat, grease, and pet-related odors.

Highly Recommended for Odor Elimination
Customers praise its ability to remove persistent smells.
Key specs
- Usage:Laundry
- Volume:32 oz
- Formulation:Enzyme Powder
- Surface Compatibility:All Fabrics
- Stain Remover:Heavy Duty
9.3

Excellent

Our Rating
7

Nature's Miracle
Nature’s Miracle Stain and Odor Remover Dog, 32 Ounces, Everyday Mess Enzymatic Odor Control Formula

17% Off
Main highlights

Immediate Stain Removal
Begins to break down and remove stains on contact.

Ideal for Pet Accidents
Perfect for tackling dog messes and pet accidents at home.

Praised Fresh Scent
Customers love its fresh citrus scent and stain removal.
9.1

Excellent

Our Rating

9.7
Stain resistance

9.3
Simple to use

9.1
Odor elimination
8

Zeiff
Zeiff Pro-Grade Multi-Purpose Probiotic Enzyme Cleaner - Pet Stain and Odor Remover, Drain Cleaner - Powerful Cleaning & Odor Eliminating Formula For Professional & Home Surfaces - 32 Ounce
Main highlights

Key Features and Benefits
Powerful, proprietary enzyme cleaner; breaks down complex stains and odors; safe, non-corrosive, and eco-friendly; ideal for professional and home use.

Ideal Use Cases
Perfect for cleaning pet stains, unclogging drains, removing odors, and general cleaning of floors, carpets, and kitchen/bathroom surfaces.

Customer Reviews Highlight
Most praised for its effectiveness in eliminating tough stains and odors, leaving areas spotlessly clean and freshly scented.
9.0

Excellent

Our Rating

9.7
Simple to use

9.1
worth the money

9.1
Aroma
9

Biokleen

Biokleen Bac-Out Enzyme Stain Remover - 32 Ounce - Natural Foam Spray, Destroys Stains & Odors Safely, for Pet Stains, Laundry, Diapers, Wine, Carpets, Eco-Friendly, Non-Toxic, Plant-Based
8.9

Very Good

Our Rating
10

Simple Solution
Simple Solution Extreme Pet Stain and Odor Eliminator Spray, Enzymatic Cleaner With 3X Pro-Bacteria Cleaning Power for Dogs & Cats, Strong Urine, Pee and Poop Smell Remover for Carpets & Floors, 32 oz
Main highlights

Powerful Enzymatic Formula
Three times stronger than regular formulas, effectively removes tough pet stains and odors.

Versatile Home Use
Ideal for cleaning dog and cat urine, feces, vomit on carpets, upholstery, and more.

Highly Praised Sprayer
Customers love the improved sprayer for its fine mist and no leakage.
8.8

Very Good

Our Rating

9.7
Odor elimination

9.3
Comfort

9.1
deep clean

10 Best enzyme cleaners of 2025

1

Angry Orange Stain Remover - 32oz Enzyme Pet Cleaner - Dog & Cat Urine Destroyer and Stain Remover - Citrus Spray Cleaning Solution - Puppy Supplies

9.3

8.9

8.7

How do we rank?

How do we rank?

Analyzing top stores

2

Biokleen Bac-Out Enzyme Stain & Odor Remover - 128 Ounces - Destroys Stains & Odors Safely, for Pet Stains, Laundry, Diapers, Wine, Carpets, & More, Eco-Friendly, Non-Toxic

9.7

9.5

9.5

3

Multi-Purpose Probiotic Enzyme Cleaner, Made in USA - Stain and Odor Remover - Concentrated - Professional & Home Strength Drains, Floors, Bathrooms, Toilets Trash Can, (128 Fl Oz, Fresh fragrance)

4

Rocco & Roxie Stain & Odor Eliminator for Strong Odor, 32oz Enzyme Pet Odor Eliminator for Home, Carpet Stain Remover for Cats & Dog Pee, Enzymatic Cat Urine Destroyer, Carpet Cleaner Spray

9.9

9.5

8.9

5

Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon

6

Enzyme Laundry Booster Odor Remover - 2 lbs Unscented Enzymatic Clothes Stain Cleaner Powder, Natural Deodorizer with Bio Active Enzymes, Detergent Additive Eliminator for Sweat, Oil, Blood - 64 Loads

7

Nature’s Miracle Stain and Odor Remover Dog, 32 Ounces, Everyday Mess Enzymatic Odor Control Formula

9.7

9.3

9.1

8

Zeiff Pro-Grade Multi-Purpose Probiotic Enzyme Cleaner - Pet Stain and Odor Remover, Drain Cleaner - Powerful Cleaning & Odor Eliminating Formula For Professional & Home Surfaces - 32 Ounce

9.7

9.1

9.1

9

Biokleen Bac-Out Enzyme Stain Remover - 32 Ounce - Natural Foam Spray, Destroys Stains & Odors Safely, for Pet Stains, Laundry, Diapers, Wine, Carpets, Eco-Friendly, Non-Toxic, Plant-Based

10

Simple Solution Extreme Pet Stain and Odor Eliminator Spray, Enzymatic Cleaner With 3X Pro-Bacteria Cleaning Power for Dogs & Cats, Strong Urine, Pee and Poop Smell Remover for Carpets & Floors, 32 oz

9.7

9.3

9.1

Sign up and get exclusive special deals