Our rankings are generated through the algorithmic analysis of thousands of customer reviews about products, brands, merchant customer service levels, popularity trends, and more. We use advanced technology, including AI, to help process and organize this information at scale, supporting our analysis with greater speed and consistency. The rankings reflect our opinion and should be a good starting point for shopping.
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10 Best enzyme cleaners of 2026
Save up to 22% off
Best Choice1
Bioda9.8Exceptional
397+
bought this week
Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer, 1 Gallon
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Type:Probiotic Enzyme Cleaner and Deodorizer
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Use Duration:Active up to 21 days
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Bottle Size:1 Gallon
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Formulation:Professional Strength
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Fragrance:Lemon and sage
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Value for Money2
Nature's Miracle9.6Exceptional
Nature's Miracle Cat Urine Destroyer Plus, Enzymatic Cleaner, 32 oz
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package dimensions:10.55 x 4.67 x 2.76 inches; 2.29 Pounds
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asin:B09KQTY9YR
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date first available:October 31, 2021
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item model number:P-98367
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best sellers rank:#1 in Cat Stain Removers
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3
GELEAN9.5Excellent
Multi-Purpose Probiotic Enzyme Citrus Cleaner, 1/2 Gallon (64 oz.) - Pet Stain and Odor Remover - Concentrated - Professional & Home Strength Drains, Floors, Bathrooms, Toilets Trash Can, Made in USA
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4
AmazonCommercial9.4Excellent
AmazonCommercial Multi-Purpose Enzyme Cleaner, Stain & Odor Remover, Pet Stain Remover, 1-Gallon, 1-Pack
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5
Nature's Miracle9.2Excellent
Nature’s Miracle Dog Stain & Odor Remover, Enzymatic Cleaner, 24 oz
18% Off-
is discontinued by manufacturer:No
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product dimensions:3.75 x 2 x 11 inches; 1.67 Pounds
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batteries:Product Specific batteries required.
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asin:B0717BLT6V
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date first available:May 30, 2017
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See Today’s Deals & Prices
6
Biokleen9.1Excellent
Biokleen Bac Out Enzyme Cleaner, Stain & Pet Odor Eliminator, Lime Scent
22% Off-
is discontinued by manufacturer:No
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product dimensions:7 x 12 x 7 inches; 0.01 ounces
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asin:B0061VZQWO
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date first available:April 6, 2011
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item model number:B00034
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7
Rocco & Roxie Supply Co.9.0Excellent
Rocco & Roxie Enzyme Stain & Odor Eliminator, 1 Gallon
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Form Factor:Spray
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Certified Safe:Seal of Approval by the Carpet and Rug Institute (CRI)
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Capacity:1-Gallon
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Cleaner Type:Enzyme Cleaner
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Ingredients:Chlorine free, color safe, no hazardous propellants or residue
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8
Eco Strong8.8Very Good
Eco Strong Pet Stain and Odor Remover - Cat Urine Enzyme Cleaner Destroyer, Urine Destroyer for Dogs, Pet Urine Enzyme Cleaner - 128 Oz
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Formula:Bio-Enzymatic
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Material Safety:Non-toxic, Non-corrosive, non-flammable, non-acidic, non-caustic
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Type:Enzymatic Cleaner
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Applications:Carpets, furniture, hardwood, tile, drains, litter boxes, garbage cans, RVs
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Volume:128 oz
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9
Zep8.5Good
Zep Urine Remover 128 Ounces Targets and Eliminates Urine Odors and Stains
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asin:B0CK2M9LQ2
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product dimensions:12.5 x 6 x 6 inches; 8.65 Pounds
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date first available:September 28, 2023
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item model number:ZUURMV128
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best sellers rank:#10 in Commercial All-Purpose Cleaners
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10
Nature's Miracle8.4Good
Nature’s Miracle Advanced Dog Stain & Odor Eliminator, Severe Mess, 32 oz
15% Off-
is discontinued by manufacturer:No
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product dimensions:4.67 x 2.89 x 11.07 inches; 2.2 Pounds
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batteries:Product Specific batteries required.
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asin:B0723HRWJW
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date first available:May 30, 2017
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