July 19, 2025

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10 Best enzyme based stain removers of 2025

Save up to 17% off

Best Choice

1

Biokleen
Biokleen Bac-Out Enzyme Stain & Odor Remover - 128 Ounces - Destroys Stains & Odors Safely, for Pet Stains, Laundry, Diapers, Wine, Carpets, & More, Eco-Friendly, Non-Toxic
Main highlights

Eco-Friendly Formula
Bac-Out uses a plant-based, biodegradable formula without harsh chemicals.

Versatile Cleaning Use
Ideal for pet accidents, laundry, carpets, and more.

Effective Odor Removal
Customers praise its ability to eliminate odors effectively.
9.9

Exceptional

Our Rating

9.7
Simple to use

9.5
Aroma

9.5
Odor elimination
How do we rank?

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Based on millions of stores and reviews

Shoppers influence our rankings
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Value for Money

2

Puracy
Puracy Stain Remover Cleaning Spray Refill - Enzyme-Powered Stain Remover Spray As Seen on TikTok, Natural Travel Spot Removal for Clothes (Free & Clear, 48 fl oz)
Main highlights

Powerful Stain Removal
Safely eliminates stains and odors, even those set in for years.

Versatile Use Cases
Ideal for clothing, carpets, sofas, and more; perfect for pet owners.

Customer Praised Performance
Highly effective on fresh and old stains, especially on carpets.
9.8

Exceptional

Our Rating

9.9
quality of ingredients

8.7
worth the money

8.0
dispense easily
3

SHOUT
Shout Active Enzyme Laundry Stain Remover Spray, Triple-Acting Formula Clings, Penetrates, and Lifts 100+ Types of Everyday Stains - Prewash Spray 22oz

13% Off
Main highlights

Triple-Action Formula
The formula clings, penetrates, and lifts stains effectively.

Versatile Stain Removal
Ideal for treating food, grass, dirt, and blood stains.

Customer Favorite for Efficiency
Praised for quickly removing stains without long wait times.
9.5

Excellent

Our Rating

9.9
Simple to use

9.7
worth the money

9.3
quality of ingredients
4

ACTIVE
Enzyme Laundry Booster Odor Remover - 2 lbs Unscented Enzymatic Clothes Stain Cleaner Powder, Natural Deodorizer with Bio Active Enzymes, Detergent Additive Eliminator for Sweat, Oil, Blood - 64 Loads
Main highlights

Effective Stain and Odor Removal
Bio enzymatic formula targets and eliminates tough stains and odors.

Perfect for Activewear and Pet Accidents
Ideal for removing sweat, grease, and pet-related odors.

Highly Recommended for Odor Elimination
Customers praise its ability to remove persistent smells.
Key specs
- Usage:Laundry
- Volume:32 oz
- Formulation:Enzyme Powder
- Stain Remover:Heavy Duty
- Special Features:Plant-based Formula
9.4

Excellent

Our Rating
5

Carbona
Carbona Laundry Stain Scrubber | Bio-Enzyme Stain Remover | Eliminates Fat, Oil, Blood, Milk, Fruit, Ketchup, Vegetables & Baby Food Stains | Save On Skin & Washable Fabrics | 1 Pack, 8.4 Fl Oz

14% Off
Main highlights

All-in-One Stain Remover
Extra-strength formula with bio-enzymes and brush applicator removes tough stains easily.

Versatile Stain Fighting
Ideal for removing grease, protein-based, and colored stains from washable fabrics.

Customer Praised Effectiveness
Highly effective on stubborn stains, praised for removing multi-washed coffee stains.
9.1

Excellent

Our Rating

9.9
Stain resistance

9.7
Simple to use

9.3
quality of ingredients
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6

ZOUT
Zout Laundry Stain Remover Spray, Triple Enzyme Formula Removes the Toughest Stains, 22 Ounce Bottles, 2-Pack
Main highlights

Triple Enzyme Power
Combines three enzymes to tackle protein, starch, and oily stains effectively.

Versatile Stain Solution
Ideal for removing blood, grass, sweat, tomato, BBQ, and oily stains.

Highly Effective Performance
Praised for its ability to remove tough stains like blood and grease.
Key specs
- Usage:Tough protein, starch, oily stains
- Volume:22 Ounce
- Formulation:Triple Enzyme Formula
- Stain Remover:Zout Laundry Stain Remover
- Special Features:Triple enzyme action
8.9

Very Good

Our Rating
7

ZOUT
Zout Laundry Stain Remover, Triple Enzyme Formula, 12 Ounce
Main highlights

Triple Enzyme Formula Effectiveness
Combines three enzymes to tackle tough protein, starch, and oily stains. Includes one 12-ounce bottle of Zout Laundry Stain Remover.

Ideal for Protein, Starch, and Oil Stains
Perfect for removing blood, grass, sweat, tomato sauce, BBQ sauce, salad dressing, and margarine stains.

Highly Effective on Various Stains
Praised for removing coffee, tea, spaghetti sauce, cooking oils, and blood stains. Users highlight its ability to revive stained clothes.
8.7

Very Good

Our Rating

9.9
deep clean

9.7
Simple to use

8.2
Aroma
8

Nature's Miracle
Nature’s Miracle Stain and Odor Remover Dog, 32 Ounces, Odor Control Formula

17% Off
Main highlights

Immediate Stain Removal
Begins to break down and remove stains on contact.

Ideal for Pet Accidents
Perfect for tackling dog messes and pet accidents at home.

Praised Fresh Scent
Customers love its fresh citrus scent and stain removal.
8.4

Good

Our Rating

9.7
Stain resistance

9.3
Simple to use

9.1
Odor elimination
9

Puracy
Puracy Stain Remover for Baby Clothes and Cloth Diapers, Newborn Baby Essentials Must Haves, Enzyme-Based Laundry Spray, Natural Spot and Odor Cleaner, 16 Oz
Main highlights

Plant-Powered Formula
Award-winning, plant-based formula safely removes stains and odors.

Versatile Use
Ideal for clothing, bedding, car seats, and more.

Stain Removal Efficiency
Praised for removing tough stains like blueberries and paint.
8.3

Good

Our Rating

9.9
Stain resistance

8.7
Simple to use

8.0
Aroma
10

THE AMAZING WHIP-IT
Whip It Cleaner, Multi Purpose Stain Remover Professional Strength Spray, Plant Based Enzyme Cleaner, Cleaning Food, Coffee, Wine, Baby Stains, Pet Stains, Over 500 uses, Made in USA, 32 OZ
Main highlights

Powerful Plant-Based Formula
Made from eucalyptus, citrus, and corn, ensuring eco-friendly cleaning.

Versatile Stain Removal
Ideal for removing stains from fabric, carpet, upholstery, and more.

Highly Praised Cleaning Performance
Customers rave about its effectiveness on red wine and coffee stains.
8.2

Good

Our Rating

9.1
Simple to use

8.9
Aroma

8.2
worth the money

10 Best enzyme based stain removers of 2025

1

Biokleen Bac-Out Enzyme Stain & Odor Remover - 128 Ounces - Destroys Stains & Odors Safely, for Pet Stains, Laundry, Diapers, Wine, Carpets, & More, Eco-Friendly, Non-Toxic

9.7

9.5

9.5

How do we rank?

How do we rank?

Analyzing top stores

2

Puracy Stain Remover Cleaning Spray Refill - Enzyme-Powered Stain Remover Spray As Seen on TikTok, Natural Travel Spot Removal for Clothes (Free & Clear, 48 fl oz)

9.9

8.7

8.0

3

Shout Active Enzyme Laundry Stain Remover Spray, Triple-Acting Formula Clings, Penetrates, and Lifts 100+ Types of Everyday Stains - Prewash Spray 22oz

9.9

9.7

9.3

4

Enzyme Laundry Booster Odor Remover - 2 lbs Unscented Enzymatic Clothes Stain Cleaner Powder, Natural Deodorizer with Bio Active Enzymes, Detergent Additive Eliminator for Sweat, Oil, Blood - 64 Loads

5

Carbona Laundry Stain Scrubber | Bio-Enzyme Stain Remover | Eliminates Fat, Oil, Blood, Milk, Fruit, Ketchup, Vegetables & Baby Food Stains | Save On Skin & Washable Fabrics | 1 Pack, 8.4 Fl Oz

9.9

9.7

9.3

6

Zout Laundry Stain Remover Spray, Triple Enzyme Formula Removes the Toughest Stains, 22 Ounce Bottles, 2-Pack

7

Zout Laundry Stain Remover, Triple Enzyme Formula, 12 Ounce

9.9

9.7

8.2

8

Nature’s Miracle Stain and Odor Remover Dog, 32 Ounces, Odor Control Formula

9.7

9.3

9.1

9

Puracy Stain Remover for Baby Clothes and Cloth Diapers, Newborn Baby Essentials Must Haves, Enzyme-Based Laundry Spray, Natural Spot and Odor Cleaner, 16 Oz

9.9

8.7

8.0

10

Whip It Cleaner, Multi Purpose Stain Remover Professional Strength Spray, Plant Based Enzyme Cleaner, Cleaning Food, Coffee, Wine, Baby Stains, Pet Stains, Over 500 uses, Made in USA, 32 OZ

9.1

8.9

8.2

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