10 Best enzyme based cleaners of 2025

Explore top picks

Editor's Choice

1

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ANGRY ORANGE
Angry Orange Stain Remover - 32oz Enzyme Pet Cleaner - Dog & Cat Urine Destroyer and Stain Remover - Citrus Spray Cleaning Solution - Puppy Supplies
Main highlights

Dual Action Enzyme Cleaner
Combines stain removal and odor elimination for pet messes.

Versatile Multi-Surface Use
Ideal for carpets, hardwood, fabrics, and more.

Citrus Scented Success
Customers praise the effective odor removal and pleasant scent.
9.8

Exceptional

Our Rating

9.3
Simple to use

8.9
Aroma

8.7
Odor elimination
How do we rank?

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Real users impact

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Based on millions of stores and reviews

Shoppers influence our rankings
Analyzing top stores
Value for Money

2

Black Diamond Stoneworks

Commercial Multi-Purpose Enzyme Cleaner & Odor Eliminator | Pet & Human Urine, Stains & Odors | Carpet, Laundry, Bathroom, Drain & Trash Deodorizer | Dog, Cat, Organic Waste Remover (1 Gallon)
9.7

Exceptional

Our Rating
3

Biokleen
Biokleen Bac-Out Enzyme Stain & Odor Remover - 128 Ounces - Destroys Stains & Odors Safely, for Pet Stains, Laundry, Diapers, Wine, Carpets, & More, Eco-Friendly, Non-Toxic
Main highlights

Eco-Friendly Formula
Bac-Out uses a plant-based, biodegradable formula without harsh chemicals.

Versatile Cleaning Use
Ideal for pet accidents, laundry, carpets, and more.

Effective Odor Removal
Customers praise its ability to eliminate odors effectively.
9.6

Exceptional

Our Rating

9.7
Simple to use

9.5
Aroma

9.5
Odor elimination
4

Bioda
Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon
Main highlights

Powerful Cleaning and Odor Control
This probiotic cleaner offers powerful cleaning and odor elimination for various surfaces, leaving a fresh lemon and sage scent.

Ideal for Pet and Household Use
Perfect for managing pet stains, odors, and maintaining household cleanliness, especially in bathrooms and kitchens.

Highly Effective Odor Elimination
Customers praise its ability to permanently eliminate tough odors, especially from pet-related incidents and organic waste.
Key specs
- volume:1 Gallon
- cleaning method:Probiotic cleaner
- scent:Lemon and sage
- specific instructions:Spray & let probiotics work
- perfume:Lemon and sage
9.5

Excellent

Our Rating
5

ACTIVE
Enzyme Laundry Booster Odor Remover - 2 lbs Unscented Enzymatic Clothes Stain Cleaner Powder, Natural Deodorizer with Bio Active Enzymes, Detergent Additive Eliminator for Sweat, Oil, Blood - 64 Loads
Main highlights

Effective Stain and Odor Removal
Bio enzymatic formula targets and eliminates tough stains and odors.

Perfect for Activewear and Pet Accidents
Ideal for removing sweat, grease, and pet-related odors.

Highly Recommended for Odor Elimination
Customers praise its ability to remove persistent smells.
Key specs
- Usage:Laundry
- Volume:32 oz
- Formulation:Enzyme Powder
- Surface Compatibility:All Fabrics
- Stain Remover:Heavy Duty
9.4

Excellent

Our Rating
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6

Zeiff
Zeiff Pro-Grade Multi-Purpose Probiotic Enzyme Cleaner - Powerful Cleaning & Odor Eliminating Formula For Professional & Home Surfaces - 32 Ounce - Fragrance Free
Main highlights

Pro Grade Cleaning Performance
Zeiff Pro-Grade Formulas deliver effective cleaning, breaking up complex organic proteins, pet stains, hair, grease, fats, and oils without leaving residue.

Versatile Multi-Purpose Use
Ideal for professional and home use, it cleans stains, odors, carpets, floors, kitchen & bathroom surfaces, and prevents clogging in drains and septic tanks.

Highly Effective Odor Elimination
Customers praise its ability to eliminate foul odors from pet accidents, food, garbage, and grease, leaving a long-lasting fresh scent.
9.2

Excellent

Our Rating

9.9
Odor elimination

9.7
Simple to use

9.1
worth the money
7

GELEAN

Multi-Purpose Probiotic Enzyme Cleaner, Made in USA - Pet Stain and Odor Remover - Concentrated - Professional & Home Strength Drains, Floors, Bathrooms, Toilets Trash Can, (1 gallon, Fresh fragrance)
9.1

Excellent

Our Rating
8

Nanoskin
Nanoskin ENZYME Multi-Purpose Cleaner & Odor Eliminator 16 Oz. - Removes Complex Organic Stains, Dirt, Grease, and Grime from Multi Surfaces | For Automotive, Floor, Kitchen, Bathroom, Plumbing
Main highlights

Key Features
Enzyme-powered cleaner breaks down organic messes, eliminates odors without fragrance, safe on multiple surfaces. Eco-friendly, non-toxic, and professional-grade effectiveness.

Ideal Use Cases
Perfect for pet stains, kitchen grease, bathroom soils, and maintaining clog-free drains. Suitable for homes, professional cleaning, and detailing environments.

Customer Praise
Most reviews highlight its exceptional ability to eliminate tough odors and stains while being safe for use around pets and children.
8.9

Very Good

Our Rating

9.7
worth the money

8.0
Odor elimination

8.0
Aroma
9

Nature's Miracle
Nature’s Miracle Urine Destroyer Plus Dog, 32 Ounces, Enzymatic Formula, Ready-to-Use
Main highlights

Powerful_Enzymatic_Cleaning
Begins breaking down stains immediately and continues until bio-mess is gone.

Versatile_Use_Scenarios
Ideal for multi-pet households, effective on carpets, floors, and fabrics.

Customer_Praised_Sprayer
Battery-powered sprayer offers ease and precision in application.
Key specs
- Enzymatic Formula:Continues working on bio-mess
- Usage:Dog urine messes
- Dimensions:10.51 x 4.61 x 2.76 inches
- Features:Safe for pets and home
- Odor Control:Breaks down odor
8.7

Very Good

Our Rating

9.7
potty training

8.9
Odor elimination

8.7
Simple to use
10

KINZUA ENVIRONMENTAL

KINZUA ENVIRONMENTAL Urine B-Gone, Professional Enzyme Odor Eliminator & Pet Stain Remover, Human, Cat & Dog Urine Cleaner, Effective on Laundry, Carpets & More, Lavender Scent, 1 Gallon
8.5

Good

Our Rating

10 Best enzyme based cleaners of 2025

1

Angry Orange Stain Remover - 32oz Enzyme Pet Cleaner - Dog & Cat Urine Destroyer and Stain Remover - Citrus Spray Cleaning Solution - Puppy Supplies

9.3

8.9

8.7

How do we rank?

How do we rank?

Analyzing top stores

2

Commercial Multi-Purpose Enzyme Cleaner & Odor Eliminator | Pet & Human Urine, Stains & Odors | Carpet, Laundry, Bathroom, Drain & Trash Deodorizer | Dog, Cat, Organic Waste Remover (1 Gallon)

3

Biokleen Bac-Out Enzyme Stain & Odor Remover - 128 Ounces - Destroys Stains & Odors Safely, for Pet Stains, Laundry, Diapers, Wine, Carpets, & More, Eco-Friendly, Non-Toxic

9.7

9.5

9.5

4

Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon

5

Enzyme Laundry Booster Odor Remover - 2 lbs Unscented Enzymatic Clothes Stain Cleaner Powder, Natural Deodorizer with Bio Active Enzymes, Detergent Additive Eliminator for Sweat, Oil, Blood - 64 Loads

6

Zeiff Pro-Grade Multi-Purpose Probiotic Enzyme Cleaner - Powerful Cleaning & Odor Eliminating Formula For Professional & Home Surfaces - 32 Ounce - Fragrance Free

9.9

9.7

9.1

7

Multi-Purpose Probiotic Enzyme Cleaner, Made in USA - Pet Stain and Odor Remover - Concentrated - Professional & Home Strength Drains, Floors, Bathrooms, Toilets Trash Can, (1 gallon, Fresh fragrance)

8

Nanoskin ENZYME Multi-Purpose Cleaner & Odor Eliminator 16 Oz. - Removes Complex Organic Stains, Dirt, Grease, and Grime from Multi Surfaces | For Automotive, Floor, Kitchen, Bathroom, Plumbing

9.7

8.0

8.0

9

Nature’s Miracle Urine Destroyer Plus Dog, 32 Ounces, Enzymatic Formula, Ready-to-Use

9.7

8.9

8.7

10

KINZUA ENVIRONMENTAL Urine B-Gone, Professional Enzyme Odor Eliminator & Pet Stain Remover, Human, Cat & Dog Urine Cleaner, Effective on Laundry, Carpets & More, Lavender Scent, 1 Gallon

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