10 Best enzymatic cleaner for urines of 2025

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Best Choice

1

AmazonCommercial
AmazonCommercial Multi-Purpose Enzyme Cleaner, 1-Gallon, 1-Pack
Main highlights

Powerful Enzymatic Cleaning
Breaks down complex organic proteins, pet stains, and odors on various surfaces.

Ideal for Pet Owners
Perfect for homes with pets, tackling messes on carpets, furniture, and more.

Highly Praised Odor Elimination
Customers love its ability to eliminate odors, not just mask them.
9.8

Exceptional

Our Rating

9.3
Simple to use

9.1
worth the money

8.9
Odor elimination
- Amazon
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Value for Money

2

Zeiff
Zeiff Pro-Grade Multi-Purpose Probiotic Enzyme Cleaner - Pet Stain and Odor Remover, Drain Cleaner - Powerful Cleaning & Odor Eliminating Formula For Professional & Home Surfaces - 1 Gallon
Main highlights

Key Features and Benefits
Powerful, multi-purpose enzyme cleaner that effortlessly breaks down organic material, leaving surfaces spotless with a refreshing citrus aroma.

Ideal Use Cases
Perfect for professional and home environments needing drain maintenance, pet stain removal, and general cleaning on various surfaces.

Customer Reviews Highlight
Most praised for its effectiveness in eliminating tough stains and odors, leaving areas impeccably clean and freshly scented.
9.7

Exceptional

Our Rating

9.7
Simple to use

9.1
worth the money

9.1
Aroma
- Amazon
3

Rocco & Roxie Supply Co.
Rocco & Roxie Stain & Odor Eliminator for Strong Odor, 32oz Enzyme Pet Odor Eliminator for Home, Carpet Stain Remover for Cats & Dog Pee, Enzymatic Cat Urine Destroyer, Carpet Cleaner Spray
Main highlights

Certified Safe and Effective
Chlorine-free, color-safe, and CRI-approved for all carpets.

Ideal for Pet Owners
Perfect for removing pet stains and odors from multiple surfaces.

Enzyme-Based Miracle Worker
Customer reviews praise its ability to eliminate odors completely.
9.6

Exceptional

Our Rating

9.9
worth the money

9.5
Simple to use

8.9
Odor elimination
- Amazon
4

Nature's Miracle
Nature's Miracle Urine Destroyer Plus for Cats, Enzymatic Formula for Severe Cat Urine Stains, 32 oz

15% Off
Main highlights

Powerful Stain and Odor Removal
Enzymatic formula breaks down severe cat urine stains and odors.

Ideal for Persistent Pet Messes
Perfect for cleaning carpets, furniture, and litter box areas.

Highly Effective Odor Control
Praised for eliminating smells, preventing repeat pet marking.
9.4

Excellent

Our Rating

9.7
Freshness

9.3
Simple to use

8.4
worth the money
- Amazon
- PetSmart
5

Simple Solution
Simple Solution Extreme Pet Stain and Odor Eliminator Spray, Enzymatic Cleaner With 3X Pro-Bacteria Cleaning Power for Dogs & Cats, Strong Urine, Pee and Poop Smell Remover for Carpets & Floors, 32 oz
Main highlights

Powerful Enzymatic Formula
Three times stronger than regular formulas, effectively removes tough pet stains and odors.

Versatile Home Use
Ideal for cleaning dog and cat urine, feces, vomit on carpets, upholstery, and more.

Highly Praised Sprayer
Customers love the improved sprayer for its fine mist and no leakage.
9.3

Excellent

Our Rating

9.7
Odor elimination

9.3
Comfort

9.1
deep clean
- Amazon
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6

Bioda
Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon
Main highlights

Powerful Cleaning and Odor Control
This probiotic cleaner offers powerful cleaning and odor elimination for various surfaces, leaving a fresh lemon and sage scent.

Ideal for Pet and Household Use
Perfect for managing pet stains, odors, and maintaining household cleanliness, especially in bathrooms and kitchens.

Highly Effective Odor Elimination
Customers praise its ability to permanently eliminate tough odors, especially from pet-related incidents and organic waste.
9.2

Excellent

Our Rating
- Amazon
7

Nature's Miracle
Nature's Miracle Urine Destroyer Plu for Dogs, Enzymatic Formula for Severe Dog Urine Stains, 32 fl oz

15% Off
Main highlights

Powerful_Enzymatic_Cleaning
Begins breaking down stains immediately and continues until bio-mess is gone.

Versatile_Use_Scenarios
Ideal for multi-pet households, effective on carpets, floors, and fabrics.

Customer_Praised_Sprayer
Battery-powered sprayer offers ease and precision in application.
9.0

Excellent

Our Rating

9.7
potty training

8.9
Odor elimination

8.7
Simple to use
- Amazon
8

Resolve
Resolve Urine Destroyer Spray – Pet Stain and Odor Remover, Carpet Cleaner Solution for Cat and Dog Urine, 32 Fl Oz
Main highlights

Odor Neutralization and Stain Removal
Neutralizes odors on contact and removes pet and food stains.

Ideal for Households with Pets and Kids
Perfect for carpets, fabrics, and hard surfaces in busy homes.

Customer Praise for Odor Elimination
Praised for effectively reducing odors, even with repeated use.
8.9

Very Good

Our Rating

9.5
Simple to use

9.1
worth the money

8.7
Aroma
- Amazon
- Max Warehouse
9

ACTIVE
Pet Odor and Stain Eliminator - 32 oz ACTIVE Enzyme Cleaner for Dog & Cat Urine, Stain Remover Spray for Carpet, Upholstery, Hardwood, Spot Cleaning, Deodorizer for Dogs Cats Pets - Natural Citrus Oil
Main highlights

Complete Odor and Stain Elimination
The enzyme-based formula effectively removes pet stains and odors, leaving a pleasant citrus scent.

Versatile Home Use
Ideal for cleaning carpets, upholstery, hardwood, and various home surfaces affected by pet messes.

Highly Praised Citrus Scent
Customers appreciate the non-overpowering citrus scent that effectively neutralizes odors.
8.8

Very Good

Our Rating
- Amazon
10

Nilodor
Nilodor Bio-Enzymatic Urine Digester with Odor Neutralizer, Cucumber Melon, 1 gallon (128 ZCM)
Main highlights

Key Features
Bio-Enzymatic formula with odor neutralizer, works continuously, suitable for hard surfaces and carpets, and features a refreshing Cucumber Melon Fragrance.

Ideal Use Cases
Perfect for use around urinals, commodes, or any frequently soiled areas in homes, schools, or commercial settings. Effective on both hard surfaces and carpets.

Customer Praise
Most reviews highlight its effectiveness in odor elimination, leaving areas smelling fresh with the pleasant scent of Cucumber Melon being particularly appreciated.
8.6

Very Good

Our Rating

9.9
Simple to use

9.9
worth the money

9.3
Aroma
- Amazon

10 Best enzymatic cleaner for urines of 2025

1

AmazonCommercial Multi-Purpose Enzyme Cleaner, 1-Gallon, 1-Pack

9.3

9.1

8.9

2

Zeiff Pro-Grade Multi-Purpose Probiotic Enzyme Cleaner - Pet Stain and Odor Remover, Drain Cleaner - Powerful Cleaning & Odor Eliminating Formula For Professional & Home Surfaces - 1 Gallon

9.7

9.1

9.1

3

Rocco & Roxie Stain & Odor Eliminator for Strong Odor, 32oz Enzyme Pet Odor Eliminator for Home, Carpet Stain Remover for Cats & Dog Pee, Enzymatic Cat Urine Destroyer, Carpet Cleaner Spray

9.9

9.5

8.9

4

Nature's Miracle Urine Destroyer Plus for Cats, Enzymatic Formula for Severe Cat Urine Stains, 32 oz

9.7

9.3

8.4

5

Simple Solution Extreme Pet Stain and Odor Eliminator Spray, Enzymatic Cleaner With 3X Pro-Bacteria Cleaning Power for Dogs & Cats, Strong Urine, Pee and Poop Smell Remover for Carpets & Floors, 32 oz

9.7

9.3

9.1

6

Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon

7

Nature's Miracle Urine Destroyer Plu for Dogs, Enzymatic Formula for Severe Dog Urine Stains, 32 fl oz

9.7

8.9

8.7

8

Resolve Urine Destroyer Spray – Pet Stain and Odor Remover, Carpet Cleaner Solution for Cat and Dog Urine, 32 Fl Oz

9.5

9.1

8.7

9

Pet Odor and Stain Eliminator - 32 oz ACTIVE Enzyme Cleaner for Dog & Cat Urine, Stain Remover Spray for Carpet, Upholstery, Hardwood, Spot Cleaning, Deodorizer for Dogs Cats Pets - Natural Citrus Oil

10

Nilodor Bio-Enzymatic Urine Digester with Odor Neutralizer, Cucumber Melon, 1 gallon (128 ZCM)

9.9

9.9

9.3

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