Our rankings are generated through the algorithmic analysis of thousands of customer reviews about products, brands, merchant customer service levels, popularity trends, and more. We use advanced technology, including AI, to help process and organize this information at scale, supporting our analysis with greater speed and consistency. The rankings reflect our opinion and should be a good starting point for shopping.
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10 Best enzymatic cleaners of 2026
Save up to 22% off
Best Choice1
GELEAN9.8Exceptional
Enzymatic Cleaner Multi-Purpose Enzyme Cleaner for Dog Urine and Poop Carpet | Cat Pee Odor eliminator Pet Urine Enzyme Drain Cleaner | Floors, Carpets, Laundry, Bathrooms, Trash Can Deodorizer, 128oz
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Container Size:128oz
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Suitable Surfaces:Floors, bathrooms, toilets, drains, trash cans, tile, porcelain, concrete, sealed floors
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Formulation:Enzymatic cleaner with probiotic technology
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Strength:Professional-strength, concentrated formula
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Weight:7.5 pounds
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Value for Money2
Bioda9.7Exceptional
Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer, 1 Gallon
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Type:Probiotic Enzyme Cleaner and Deodorizer
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Use Duration:Active up to 21 days
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Bottle Size:1 Gallon
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Formulation:Professional Strength
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Fragrance:Lemon and sage
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3
Nature's Miracle9.6Exceptional
Nature’s Miracle Advanced Dog Stain & Odor Eliminator, Severe Mess, 32 oz
15% Off-
is discontinued by manufacturer:No
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product dimensions:4.67 x 2.89 x 11.07 inches; 2.2 Pounds
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batteries:Product Specific batteries required.
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asin:B0723HRWJW
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date first available:May 30, 2017
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4
Rocco & Roxie Supply Co.9.5Excellent
Rocco & Roxie Enzyme Stain & Odor Eliminator, 32 Fl Oz
15% Off-
Type:Enzyme Cleaner
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Form:Spray
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Volume:32 Fl Oz
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Certification:Seal of Approval by the Carpet and Rug Institute (CRI)
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Color:Clear
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5
Nature's Miracle9.3Excellent
Nature’s Miracle Dog Stain & Odor Remover, Enzymatic Cleaner, 24 oz
18% Off-
is discontinued by manufacturer:No
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product dimensions:3.75 x 2 x 11 inches; 1.67 Pounds
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batteries:Product Specific batteries required.
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asin:B0717BLT6V
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date first available:May 30, 2017
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6
AmazonCommercial9.2Excellent
AmazonCommercial Multi-Purpose Enzyme Cleaner, Stain & Odor Remover, Pet Stain Remover, 1-Gallon, 1-Pack
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7
GELEAN9.1Excellent
Multi-Purpose Probiotic Enzyme Citrus Cleaner, 1/2 Gallon (64 oz.) - Pet Stain and Odor Remover - Concentrated - Professional & Home Strength Drains, Floors, Bathrooms, Toilets Trash Can, Made in USA
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8
Biokleen9.0Excellent
Biokleen Bac Out Enzyme Cleaner, Stain & Pet Odor Eliminator, Lime Scent
22% Off-
is discontinued by manufacturer:No
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product dimensions:7 x 12 x 7 inches; 0.01 ounces
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asin:B0061VZQWO
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date first available:April 6, 2011
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item model number:B00034
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9
Nature's Miracle8.8Very Good
Nature's Miracle Cat Urine Destroyer Plus, Enzymatic Cleaner, 32 oz
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package dimensions:10.55 x 4.67 x 2.76 inches; 2.29 Pounds
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asin:B09KQTY9YR
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date first available:October 31, 2021
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item model number:P-98367
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best sellers rank:#1 in Cat Stain Removers
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10
Rocco & Roxie Supply Co.8.6Very Good
Rocco & Roxie Extreme Enzyme Stain & Odor Eliminator Spray
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Type:Bio-enzymatic cleaner
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Form:N/A
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Volume:N/A
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Certification:Carpet and Rug Institute (CRI) Seal of Approval
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Color:N/A
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Frequently Asked Questions
- What is an enzymatic cleaner?
- How does an enzymatic cleaner work?
- Can enzymatic cleaners be used on any surface?
- Are enzymatic cleaners eco-friendly?
- Can I use an enzymatic cleaner for pet stains?