September 13, 2025

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10 Best enzymatic cleaners of 2025

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Best Choice

1

Bioda
Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon
Main highlights

Powerful Cleaning and Odor Control
This probiotic cleaner offers powerful cleaning and odor elimination for various surfaces, leaving a fresh lemon and sage scent.

Ideal for Pet and Household Use
Perfect for managing pet stains, odors, and maintaining household cleanliness, especially in bathrooms and kitchens.

Highly Effective Odor Elimination
Customers praise its ability to permanently eliminate tough odors, especially from pet-related incidents and organic waste.
Key specs
- volume:1 Gallon
- cleaning method:Probiotic cleaner
- scent:Lemon and sage
- specific instructions:Spray & let probiotics work
- perfume:Lemon and sage
9.8

Exceptional

Our Rating
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Value for Money

2

Zeiff
Zeiff Pro-Grade Multi-Purpose Probiotic Enzyme Cleaner - Powerful Cleaning & Odor Eliminating Formula For Professional & Home Surfaces - 1 Gallon - Fragrance Free
Main highlights

Key Features and Benefits
Powerful enzyme cleaner that tackles organic proteins, pet stains, and grime, leaving no residue. Safe, effective, and environmentally friendly.

Ideal Use Cases
Perfect for both professional and home use, excelling in cleaning drains, carpets, kitchen and bathroom surfaces, and eliminating odors.

Customer Reviews Highlight
Most praised for its unparalleled cleaning power, leaving areas spotless and remarkably odor-free, with noticeable results.
9.6

Exceptional

Our Rating

9.7
Simple to use

9.1
worth the money

9.1
Aroma
3

Rocco & Roxie Supply Co.
Rocco & Roxie Stain & Odor Eliminator for Strong Odor, 32oz Enzyme Pet Odor Eliminator for Home, Carpet Stain Remover for Cats & Dog Pee, Enzymatic Cat Urine Destroyer, Carpet Cleaner Spray

20% Off
Main highlights

Certified Safe and Effective
Chlorine-free, color-safe, and CRI-approved for all carpets.

Ideal for Pet Owners
Perfect for removing pet stains and odors from multiple surfaces.

Enzyme-Based Miracle Worker
Customer reviews praise its ability to eliminate odors completely.
Key specs
- Formula:Enzyme Activated
- Use:Stain, Odor Removal
- Stain Type:Urine, Feces, Vomit
- Packaging:Spray
- Safety:Chlorine free, Safe for pets
9.5

Excellent

Our Rating

9.9
worth the money

9.5
Simple to use

8.9
Odor elimination
4

Simple Solution
Simple Solution Extreme Pet Stain and Odor Eliminator Spray, Enzymatic Cleaner With 3X Pro-Bacteria Cleaning Power for Dogs & Cats, Strong Urine, Pee and Poop Smell Remover for Carpets & Floors, 32 oz
Main highlights

Powerful Enzymatic Formula
Three times stronger than regular formulas, effectively removes tough pet stains and odors.

Versatile Home Use
Ideal for cleaning dog and cat urine, feces, vomit on carpets, upholstery, and more.

Highly Praised Sprayer
Customers love the improved sprayer for its fine mist and no leakage.
9.4

Excellent

Our Rating

9.7
Odor elimination

9.3
Comfort

9.1
deep clean
5

Nature's Miracle
Nature’s Miracle Stain and Odor Remover Dog, Odor Control Formula, 32 oz

17% Off
Main highlights

Immediate Stain Removal
Begins to break down and remove stains on contact.

Ideal for Pet Accidents
Perfect for tackling dog messes and pet accidents at home.

Praised Fresh Scent
Customers love its fresh citrus scent and stain removal.
9.3

Excellent

Our Rating

9.7
Stain resistance

9.3
Simple to use

9.1
Odor elimination
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6

Nature's Miracle
Nature’s Miracle Advanced Stain and Odor Eliminator Dog, 32 Ounces, Fresh Scent, Severe Mess Enzymatic Formula For Tough Pet Messes

15% Off
Main highlights

Powerful Enzymatic Formula
Effectively eliminates tough stains and odors from dog messes.

Versatile Use Cases
Ideal for cleaning dog urine, diarrhea, vomit, and other bio-based accidents.

Highly Praised Odor Removal
Customers commend its ability to remove pet and other odors.
9.2

Excellent

Our Rating

9.5
Stain resistance

9.3
deep clean

9.1
Simple to use
7

Nature's Miracle
Nature’s Miracle Urine Destroyer Plus Cat, 32 Ounces, Enzymatic Formula, Ready-to-Use
Main highlights

Powerful Stain and Odor Removal
Enzymatic formula breaks down severe cat urine stains and odors.

Ideal for Persistent Pet Messes
Perfect for cleaning carpets, furniture, and litter box areas.

Highly Effective Odor Control
Praised for eliminating smells, preventing repeat pet marking.
Key specs
- Formula:Enzymatic
- Use:Cat urine messes
- Stain Type:Bio-based mess
- Packaging:2.29 Pounds
- Safety:Safe for pets
9.0

Excellent

Our Rating

9.7
Freshness

9.3
Simple to use

8.4
worth the money
8

Resolve
Resolve Urine Destroyer Spray – Pet Stain and Odor Remover, Carpet Cleaner Solution for Cat and Dog Urine, 32 Fl Oz
Main highlights

Odor Neutralization and Stain Removal
Neutralizes odors on contact and removes pet and food stains.

Ideal for Households with Pets and Kids
Perfect for carpets, fabrics, and hard surfaces in busy homes.

Customer Praise for Odor Elimination
Praised for effectively reducing odors, even with repeated use.
Key specs
- odor removal:Neutralizes & destroys odors
- surface compatibility:Carpets, fabrics, hard surfaces
- volume:N/A
- active ingredients:N/A
- scent:N/A
8.9

Very Good

Our Rating

9.5
Simple to use

9.1
worth the money

8.7
Aroma
9

ACTIVE
Enzyme Laundry Booster Odor Remover - 2 lbs Unscented Enzymatic Clothes Stain Cleaner Powder, Natural Deodorizer with Bio Active Enzymes, Detergent Additive Eliminator for Sweat, Oil, Blood - 64 Loads

20% Off
Main highlights

Effective Stain and Odor Removal
Bio enzymatic formula targets and eliminates tough stains and odors.

Perfect for Activewear and Pet Accidents
Ideal for removing sweat, grease, and pet-related odors.

Highly Recommended for Odor Elimination
Customers praise its ability to remove persistent smells.
Key specs
- Usage:Laundry
- Formulation:Enzyme Powder
- Surface Compatibility:All Fabrics
- Stain Remover:Heavy Duty
- Special Features:Plant-based Formula
8.8

Very Good

Our Rating
10

KIDS 'N' PETS
KIDS 'N' PETS Instant All-Purpose Stain & Odor Remover Permanently Eliminates Dog Pee, Cat Urine, Other Smells, Spots from Home Carpet, Couch, Furniture, Mattress, Fabric. Non-Toxic, Child Safe - 27oz
Main highlights

Neutralizes Odors and Stains
Patented formula effectively neutralizes and eliminates tough odors and stains, ensuring a deep clean.

Versatile Application
Ideal for use on carpets, furniture, bedding, and any water-safe surfaces.

Highly Effective Odor Removal
Praised for exceptional ability to permanently eliminate urine and other odors.
Key specs
- Usage:Household stains & odors
- Formulation:Patented formula
- Surface Compatibility:Carpet, furniture, mattresses
- Stain Remover:Instant All-purpose
- Special Features:Non-Toxic & Cruelty-Free
8.7

Very Good

Our Rating

9.9
Stain resistance

9.5
Simple to use

9.1
worth the money

10 Best enzymatic cleaners of 2025

1

Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon

How do we rank?

How do we rank?

Analyzing top stores

2

Zeiff Pro-Grade Multi-Purpose Probiotic Enzyme Cleaner - Powerful Cleaning & Odor Eliminating Formula For Professional & Home Surfaces - 1 Gallon - Fragrance Free

9.7

9.1

9.1

3

Rocco & Roxie Stain & Odor Eliminator for Strong Odor, 32oz Enzyme Pet Odor Eliminator for Home, Carpet Stain Remover for Cats & Dog Pee, Enzymatic Cat Urine Destroyer, Carpet Cleaner Spray

9.9

9.5

8.9

4

Simple Solution Extreme Pet Stain and Odor Eliminator Spray, Enzymatic Cleaner With 3X Pro-Bacteria Cleaning Power for Dogs & Cats, Strong Urine, Pee and Poop Smell Remover for Carpets & Floors, 32 oz

9.7

9.3

9.1

5

Nature’s Miracle Stain and Odor Remover Dog, Odor Control Formula, 32 oz

9.7

9.3

9.1

6

Nature’s Miracle Advanced Stain and Odor Eliminator Dog, 32 Ounces, Fresh Scent, Severe Mess Enzymatic Formula For Tough Pet Messes

9.5

9.3

9.1

7

Nature’s Miracle Urine Destroyer Plus Cat, 32 Ounces, Enzymatic Formula, Ready-to-Use

9.7

9.3

8.4

8

Resolve Urine Destroyer Spray – Pet Stain and Odor Remover, Carpet Cleaner Solution for Cat and Dog Urine, 32 Fl Oz

9.5

9.1

8.7

9

Enzyme Laundry Booster Odor Remover - 2 lbs Unscented Enzymatic Clothes Stain Cleaner Powder, Natural Deodorizer with Bio Active Enzymes, Detergent Additive Eliminator for Sweat, Oil, Blood - 64 Loads

10

KIDS 'N' PETS Instant All-Purpose Stain & Odor Remover Permanently Eliminates Dog Pee, Cat Urine, Other Smells, Spots from Home Carpet, Couch, Furniture, Mattress, Fabric. Non-Toxic, Child Safe - 27oz

9.9

9.5

9.1

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