What is an enzymatic cleaner?

An enzymatic cleaner is a cleaning product that uses natural enzymes to break down stains and odors.

How does an enzymatic cleaner work?

It works by breaking down the structure of the stain or odor molecule, making it easier to remove.

Can enzymatic cleaners be used on any surface?

Most enzymatic cleaners can be used on a variety of surfaces, but it's always best to check the label.

Are enzymatic cleaners eco-friendly?

Generally, enzymatic cleaners are considered eco-friendly as they use natural enzymes instead of harsh chemicals.

Can I use an enzymatic cleaner for pet stains?

Yes, enzymatic cleaners are often used to remove pet stains and odors.

February 21, 2026

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10 Best enzymatic cleaners of 2026

Save up to 21% off

1

Bioda
Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon
Main highlights

Powerful Cleaning and Odor Control
This probiotic cleaner offers powerful cleaning and odor elimination for various surfaces, leaving a fresh lemon and sage scent.

Ideal for Pet and Household Use
Perfect for managing pet stains, odors, and maintaining household cleanliness, especially in bathrooms and kitchens.

Highly Effective Odor Elimination
Customers praise its ability to permanently eliminate tough odors, especially from pet-related incidents and organic waste.
Key specs
- volume:1 Gallon
- cleaning method:Probiotic cleaner
- scent:Lemon and sage
- specific instructions:Spray & let probiotics work
- perfume:Lemon and sage
9.8

Exceptional

Our Rating
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2

Bioda
Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon
Main highlights

Powerful Cleaning and Odor Control
This probiotic cleaner offers powerful cleaning and odor elimination for various surfaces, leaving a fresh lemon and sage scent.

Ideal for Pet and Household Use
Perfect for managing pet stains, odors, and maintaining household cleanliness, especially in bathrooms and kitchens.

Highly Effective Odor Elimination
Customers praise its ability to permanently eliminate tough odors, especially from pet-related incidents and organic waste.
Key specs
- volume:1 Gallon
- cleaning method:Probiotic cleaner
- scent:Lemon and sage
- specific instructions:Spray & let probiotics work
- perfume:Lemon and sage
9.7

Exceptional

Our Rating
3

Resolve
Resolve Pet Expert Stain and Odor Remover, Carpet Cleaner, Pet Stain and Odor Remover, Carpet & Upholstery Cleaner - Removes Stains and Odors, 22 oz

15% Off
Main highlights

Key Features
Exceptional stain removal on first use, prevents resoiling, safe for pets and kids.

Ideal Use Cases
Perfect for tackling pet urine, feces, vomit, and everyday stains like red wine, grape juice, and grease.

Customer Praise
Most reviews highlight its effectiveness on tough stains and appreciate the safety aspect for pets and children.
9.6

Exceptional

Our Rating

9.5
Simple to use

9.3
worth the money
4

Resolve
Resolve Pet Expert Stain and Odor Remover, Carpet Cleaner, Pet Stain and Odor Remover, Carpet & Upholstery Cleaner - Removes Stains and Odors, 22 oz

19% Off
Main highlights

Key Features
Exceptional stain removal on first use, prevents resoiling, safe for pets and kids.

Ideal Use Cases
Perfect for tackling pet urine, feces, vomit, and everyday stains like red wine, grape juice, and grease.

Customer Praise
Most reviews highlight its effectiveness on tough stains and appreciate the safety aspect for pets and children.
9.5

Excellent

Our Rating

9.5
Simple to use

9.3
worth the money
5

Rocco & Roxie Supply Co.
Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray Clear, 32 Fl Oz
Main highlights

Certified Safe and Effective
Chlorine-free, color-safe, and CRI-approved for all carpets.

Ideal for Pet Owners
Perfect for removing pet stains and odors from multiple surfaces.

Enzyme-Based Miracle Worker
Customer reviews praise its ability to eliminate odors completely.
Key specs
- Formula:Enzyme Activated
- Use:Stain, Odor Removal
- Stain Type:Urine, Feces, Vomit
- Packaging:Spray
- Safety:Chlorine free, Safe for pets
9.4

Excellent

Our Rating

9.9
worth the money

9.5
Simple to use

8.9
Odor elimination
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6

Rocco & Roxie Supply Co.
Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray Clear, 32 Fl Oz
Main highlights

Certified Safe and Effective
Chlorine-free, color-safe, and CRI-approved for all carpets.

Ideal for Pet Owners
Perfect for removing pet stains and odors from multiple surfaces.

Enzyme-Based Miracle Worker
Customer reviews praise its ability to eliminate odors completely.
Key specs
- Formula:Enzyme Activated
- Use:Stain, Odor Removal
- Stain Type:Urine, Feces, Vomit
- Packaging:Spray
- Safety:Chlorine free, Safe for pets
9.3

Excellent

Our Rating

9.9
worth the money

9.5
Simple to use

8.9
Odor elimination
7

Magic Finish

Magic Finish Pet Odor & Stain Remover (32 oz) – Enzyme Carpet Cleaner for Dog & Cat Urine, Vomit, and Messes – Kid & Pet-Friendly Rug & Multisurface Upholstery Deodorizer with Apple Blossom Scent
9.1

Excellent

Our Rating
8

Nature's Miracle
Nature’s Miracle Stain and Odor Remover Dog, 32 Ounces, Everyday Mess Enzymatic Odor Control Formula

17% Off
Main highlights

Immediate Stain Removal
Begins to break down and remove stains on contact.

Ideal for Pet Accidents
Perfect for tackling dog messes and pet accidents at home.

Praised Fresh Scent
Customers love its fresh citrus scent and stain removal.
8.9

Very Good

Our Rating

9.7
Stain resistance

9.3
Simple to use

9.1
Odor elimination
9

Nature's Miracle
Nature’s Miracle Stain and Odor Remover Dog, 32 Ounces, Everyday Mess Enzymatic Odor Control Formula

21% Off
Main highlights

Immediate Stain Removal
Begins to break down and remove stains on contact.

Ideal for Pet Accidents
Perfect for tackling dog messes and pet accidents at home.

Praised Fresh Scent
Customers love its fresh citrus scent and stain removal.
8.7

Very Good

Our Rating

9.7
Stain resistance

9.3
Simple to use

9.1
Odor elimination
10

Nature's Miracle
Nature’s Miracle Urine Destroyer Plus Cat, 32 Ounces,Unscented, Enzymatic Formula, Ready-to-Use
Main highlights

Powerful Stain and Odor Removal
Enzymatic formula breaks down severe cat urine stains and odors.

Ideal for Persistent Pet Messes
Perfect for cleaning carpets, furniture, and litter box areas.

Highly Effective Odor Control
Praised for eliminating smells, preventing repeat pet marking.
Key specs
- Formula:Enzymatic
- Use:Cat urine messes
- Stain Type:Bio-based mess
- Packaging:2.29 Pounds
- Safety:Safe for pets
8.6

Very Good

Our Rating

9.7
Freshness

9.3
Simple to use

8.4
worth the money

Frequently Asked Questions

What is an enzymatic cleaner?
An enzymatic cleaner is a cleaning product that uses natural enzymes to break down stains and odors.

How does an enzymatic cleaner work?
It works by breaking down the structure of the stain or odor molecule, making it easier to remove.

Can enzymatic cleaners be used on any surface?
Most enzymatic cleaners can be used on a variety of surfaces, but it's always best to check the label.

Are enzymatic cleaners eco-friendly?
Generally, enzymatic cleaners are considered eco-friendly as they use natural enzymes instead of harsh chemicals.

Can I use an enzymatic cleaner for pet stains?
Yes, enzymatic cleaners are often used to remove pet stains and odors.

10 Best enzymatic cleaners of 2026

1

Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon

How do we rank?

How do we rank?

Analyzing top stores

2

Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon

3

Resolve Pet Expert Stain and Odor Remover, Carpet Cleaner, Pet Stain and Odor Remover, Carpet & Upholstery Cleaner - Removes Stains and Odors, 22 oz

9.5

9.3

4

Resolve Pet Expert Stain and Odor Remover, Carpet Cleaner, Pet Stain and Odor Remover, Carpet & Upholstery Cleaner - Removes Stains and Odors, 22 oz

9.5

9.3

5

Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray Clear, 32 Fl Oz

9.9

9.5

8.9

6

Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray Clear, 32 Fl Oz

9.9

9.5

8.9

7

Magic Finish Pet Odor & Stain Remover (32 oz) – Enzyme Carpet Cleaner for Dog & Cat Urine, Vomit, and Messes – Kid & Pet-Friendly Rug & Multisurface Upholstery Deodorizer with Apple Blossom Scent

8

Nature’s Miracle Stain and Odor Remover Dog, 32 Ounces, Everyday Mess Enzymatic Odor Control Formula

9.7

9.3

9.1

9

Nature’s Miracle Stain and Odor Remover Dog, 32 Ounces, Everyday Mess Enzymatic Odor Control Formula

9.7

9.3

9.1

10

Nature’s Miracle Urine Destroyer Plus Cat, 32 Ounces,Unscented, Enzymatic Formula, Ready-to-Use

9.7

9.3

8.4

Frequently Asked Questions

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