June 20, 2025

Advertising Disclosure

10 Best dog liver supplements of 2025

Explore top picks

Best Choice

1

Nutramax Laboratories
Nutramax Laboratories Denamarin Liver Health Supplement for Large Dogs - With S-Adenosylmethionine (SAMe) and Silybin, 30 Tablets(Pack of 1)
Main highlights

Veterinarian Recommended Liver Support
Denamarin is the #1 vet-recommended liver supplement for dogs, enhancing liver detoxification and health.

Ideal for Dogs Needing Liver Support
Perfect for dogs requiring liver detoxification and immune support.

Highly Praised for Effectiveness
Customers appreciate its effectiveness in improving their dogs' health.
Key specs
- Formulation:Supplement
- Ingredients:s-adenosylmethionine, Silybin
- Dimensions:1.88 x 1.88 x 3.63 inches
- Health Benefit:Liver support for dogs
- Country of Origin:USA
9.8

Exceptional

Our Rating

9.3
quality of ingredients

8.0
Simple to use

8.0
worth the money
How do we rank?

Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service levels, popularity trends, and more. The rankings reflect our opinion and should be a good starting point for shopping. By purchasing the products we rank, you’ll get the lowest price we found while we may receive a commission at no cost to you, which will help us continue to provide you with value.
Value for Money

2

Nutramax Laboratories
Nutramax Denamarin Liver Health Supplement for Large Dogs - With S-Adenosylmethionine (SAMe) and Silybin, 30Count(Pack of 1)
Main highlights

Veterinarian Recommended Liver Support
Denamarin is the top veterinarian-recommended supplement for enhancing liver health in dogs.

Ideal for Older Dogs with Liver Issues
Perfect for senior dogs experiencing liver problems, especially when on NSAIDs.

Improves Liver Health
Customers praise Denamarin for visibly improving liver health and quality of life in dogs.
9.7

Exceptional

Our Rating

8.2
Simple to use

8.0
worth the money

8.0
Absorbency
3

Zesty Paws
Zesty Paws Liver Support Supplement for Dogs - with Milk Thistle Extract, Turmeric Curcumin, Choline - Soft Chew Formula - for Dog Liver Function
Main highlights

Liver Health Support
Zesty Paws Liver Support Bites contain Milk Thistle and Turmeric Curcumin for canine liver health.

Ideal for Liver Issues
Best for dogs showing signs like weight changes and fatigue.

Customer Service Praise
Highly rated for excellent customer service, enhancing purchase confidence.
Key specs
- Formulation:Chewable supplements
- Ingredients:Milk Thistle, BioPerine
- Dimensions:3.5 x 3.5 x 4 inches
- Health Benefit:Supports liver health
- Country of Origin:USA
9.5

Excellent

Our Rating

8.7
quality of ingredients

8.7
Comfort

8.4
Aroma
4

Coco and Luna
Milk Thistle for Dogs - 120 Chewable Tablets - Silymarin - Liver and Kidney Support with EPA & DHA - Detox - Liver Supplement for Dogs with Choline and L-Arginine
Main highlights

Liver and Kidney Support
Contains Milk Thistle, Choline, L-Arginine for detox and vitality.

Ideal for Senior Dogs
Perfect for older dogs needing liver and kidney support.

Flavor and Size
Dogs enjoy the flavor, though tablets may need halving.
9.3

Excellent

Our Rating

9.3
Sheerness

8.9
pain management

8.9
Flavor
5

Nutramax Laboratories
Nutramax Laboratories Denamarin Liver Health Supplement for Medium Dogs - With S-Adenosylmethionine (SAMe) and Silybin, 30 Tablets
Main highlights

Veterinarian_Recommended_Liver_Support
Denamarin is the top veterinarian-recommended liver supplement with SAMe and Silybin for enhanced liver health.

Ideal_for_Liver_Stress_and_Support
Best for dogs with liver stress or those needing liver support due to medications or conditions.

Proven_Effectiveness_in_Improving_Liver_Health
Customers praise Denamarin for significantly improving liver enzyme levels and overall liver health.
9.2

Excellent

Our Rating

9.5
quality of ingredients

9.3
Aroma

8.7
worth the money
See Today’s Deals & Prices
6

Natural Dog Company
Natural Dog Company Stinky Liver & Kidney Supplement Chews, Complete Detox Cleanse & Major Organ Support, Advanced Liver and Kidney Health Support for Dogs, Enhances Digestion and Immunity 90 Chews
Main highlights

Supports Vital Organs and Overall Wellness
Formulated to bolster liver and kidney health, enhance digestion, boost immunity, and support heart health for holistic dog wellness.

Ideal for Aging Dogs and Prone Breeds
Perfect for aging dogs and breeds prone to liver issues, offering essential support for maintaining health and well-being.

Customer Praised for Effective Results
Highly rated for improving dogs' well-being, with noticeable benefits like shiny coats and ease of use.
Key specs
- Formulation:Chews
- Ingredients:Curcumin Extract, NAC, Milk Thistle, Choline Bitartrate, Apple Cider Vinegar, Dandelion Root Powder
- Dimensions:3.66 x 3.58 x 3.43 inches
- Health Benefit:Liver and kidney support
- Country of Origin:USA
9.1

Excellent

Our Rating

9.1
Gentle

8.4
quality of ingredients

8.4
Flavor
7

Nutramax Laboratories

Nutramax Laboratories Denamarin Liver Health Supplement for Medium Dogs - With S-Adenosylmethionine (SAMe) and Silybin, 30 Tablets
9.0

Excellent

Our Rating
8

Nutramax Laboratories
Nutramax Laboratories Denamarin Liver Health Supplement for Small Dogs and Cats - With S-Adenosylmethionine (SAMe) and Silybin, 30 Tablets
Main highlights

Comprehensive Liver Support
Denamarin contains SAMe and Silybin to boost liver health and detoxification.

Veterinarian Recommended Use
Ideal for dogs and cats needing liver health support.

Cost Savings Benefit
Customers appreciate the affordability compared to vet prices.
Key specs
- Formulation:Supplement
- Ingredients:S-adenosylmethionine, Silybin
- Dimensions:1.88 x 1.88 x 3.63 inches
- Health Benefit:Liver support
- Country of Origin:USA
8.9

Very Good

Our Rating

9.9
quality of ingredients

9.3
dispense easily

8.2
Simple to use
9

WONDER PAWS
Wonder Paws Milk Thistle, Liver Support for Dogs, Supports Kidney Function for Pets, Detox, Hepatic Support, with Wild Alaskan Salmon Oil & Curcumin, Omega 3 EPA & DHA (2 Oz)
Main highlights

Optimal Liver and Kidney Support
Combines Milk Thistle, Salmon Oil, and Curcumin for liver and kidney health.

Daily Use for All Breeds
Ideal for daily use with small, medium, and large dogs.

Dog-Approved Flavor
Most praised feature: Dogs enjoy the taste mixed with food.
8.8

Very Good

Our Rating

9.1
Simple to use

8.7
worth the money

8.2
Flavor
10

SilymarinAdvanced
SilymarinAdvanced Liver Health Supplement for Large Dogs - Milk Thistle for Dogs Liver Support with S-Adenosylmethionine (Same) & Silybin - 30 Tablets
Main highlights

Key Features and Benefits
Combines S-Adenosylmethionine and Silybin for liver health and cognitive support.

Ideal Use Cases
Perfect for large dogs with liver issues needing antioxidant support.

Praised Feature in Reviews
Affordable alternative to Denamarin with easy-to-break tablets.
Key specs
- Formulation:Unique formulation
- Ingredients:Silybum Marianum, S-adenosylmethionine
- Dimensions:1.9 x 1.9 x 3.5 inches
- Health Benefit:Liver detoxifying and antioxidant
- Country of Origin:USA
8.7

Very Good

Our Rating

8.2
worth the money

8.2
quality of ingredients

8.0
Aroma

10 Best dog liver supplements of 2025

1

Nutramax Laboratories Denamarin Liver Health Supplement for Large Dogs - With S-Adenosylmethionine (SAMe) and Silybin, 30 Tablets(Pack of 1)

9.3

8.0

8.0

2

Nutramax Denamarin Liver Health Supplement for Large Dogs - With S-Adenosylmethionine (SAMe) and Silybin, 30Count(Pack of 1)

8.2

8.0

8.0

3

Zesty Paws Liver Support Supplement for Dogs - with Milk Thistle Extract, Turmeric Curcumin, Choline - Soft Chew Formula - for Dog Liver Function

8.7

8.7

8.4

4

Milk Thistle for Dogs - 120 Chewable Tablets - Silymarin - Liver and Kidney Support with EPA & DHA - Detox - Liver Supplement for Dogs with Choline and L-Arginine

9.3

8.9

8.9

5

Nutramax Laboratories Denamarin Liver Health Supplement for Medium Dogs - With S-Adenosylmethionine (SAMe) and Silybin, 30 Tablets

9.5

9.3

8.7

6

Natural Dog Company Stinky Liver & Kidney Supplement Chews, Complete Detox Cleanse & Major Organ Support, Advanced Liver and Kidney Health Support for Dogs, Enhances Digestion and Immunity 90 Chews

9.1

8.4

8.4

7

Nutramax Laboratories Denamarin Liver Health Supplement for Medium Dogs - With S-Adenosylmethionine (SAMe) and Silybin, 30 Tablets

8

Nutramax Laboratories Denamarin Liver Health Supplement for Small Dogs and Cats - With S-Adenosylmethionine (SAMe) and Silybin, 30 Tablets

9.9

9.3

8.2

9

Wonder Paws Milk Thistle, Liver Support for Dogs, Supports Kidney Function for Pets, Detox, Hepatic Support, with Wild Alaskan Salmon Oil & Curcumin, Omega 3 EPA & DHA (2 Oz)

9.1

8.7

8.2

10

SilymarinAdvanced Liver Health Supplement for Large Dogs - Milk Thistle for Dogs Liver Support with S-Adenosylmethionine (Same) & Silybin - 30 Tablets

8.2

8.2

8.0

Sign up and get exclusive special deals