10 Best dog urine enzymatic cleaners of 2025

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Editor's Choice

1

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ANGRY ORANGE
ANGRY ORANGE Pet Odor Eliminator for Dog and Cat Urine, Carpet Stains, and Strong Smells – Citrus Cleaner with Natural Orange Oil – 24 oz
Main highlights

Powerful Odor Elimination
Targets and destroys strong pet odors at the source.

Versatile Use Cases
Effective on carpets, upholstery, tiles, and more surfaces.

Customer Praised Effectiveness
Customers appreciate its ability to eliminate cat urine smell.
9.9

Exceptional

Our Rating
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Value for Money

2

ANGRY ORANGE
Angry Orange Stain Remover - 32oz Enzyme Pet Cleaner - Dog & Cat Urine Destroyer and Stain Remover - Citrus Spray Cleaning Solution - Puppy Supplies
Main highlights

Dual Action Enzyme Cleaner
Combines stain removal and odor elimination for pet messes.

Versatile Multi-Surface Use
Ideal for carpets, hardwood, fabrics, and more.

Citrus Scented Success
Customers praise the effective odor removal and pleasant scent.
9.8

Exceptional

Our Rating

9.3
Simple to use

8.9
Aroma

8.7
Odor elimination
3

Eco Strong
Eco Strong Outdoor Odor Eliminator | Outside Dog Urine Enzyme Cleaner – Powerful Pet, Cat, Animal Scent Deodorizer | Professional Strength for Yard, Turf, Kennels, Patios, Decks (Gallon with Sprayer)
Main highlights

Chemical-Free Odor Eraser
Powerful natural formula eliminates pet odors with eucalyptus scent.

Outdoor Versatility
Ideal for yards, kennels, patios, and more.

Customer Praised Effectiveness
Highly effective at removing persistent outdoor pet odors.
9.7

Exceptional

Our Rating

9.1
Simple to use

8.9
Aroma

8.7
Odor elimination
4

KINZUA ENVIRONMENTAL
KINZUA ENVIRONMENTAL Urine B-Gone, Professional Enzyme Odor Eliminator & Pet Stain Remover, Human, Cat & Dog Urine Cleaner, Effective on Laundry, Carpets & More, Original Scent, 1 Gallon
Main highlights

High Enzyme Count for Effective Cleaning
Contains over 200 billion enzymes to liquefy, digest, and eliminate urine and feces.

Versatile Applications for Pet Owners
Ideal for carpets, upholstery, laundry, drains, and toilets; perfect for households with pets.

Customer Praised Stain and Odor Removal
Highly effective in removing pet stains and odors, leaving carpets smelling fresh.
9.4

Excellent

Our Rating

9.1
Simple to use

8.9
Odor elimination

8.4
Aroma
5

Rocco & Roxie Supply Co.
Rocco & Roxie Stain & Odor Eliminator for Strong Odor, 32oz Enzyme Pet Odor Eliminator for Home, Carpet Stain Remover for Cats & Dog Pee, Enzymatic Cat Urine Destroyer, Carpet Cleaner Spray
Main highlights

Certified Safe and Effective
Chlorine-free, color-safe, and CRI-approved for all carpets.

Ideal for Pet Owners
Perfect for removing pet stains and odors from multiple surfaces.

Enzyme-Based Miracle Worker
Customer reviews praise its ability to eliminate odors completely.
9.3

Excellent

Our Rating

9.9
worth the money

9.5
Simple to use

8.9
Odor elimination
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6

Nature's Miracle
Nature's Miracle Urine Destroyer Plu for Dogs, Enzymatic Formula for Severe Dog Urine Stains, 32 fl oz

15% Off
Main highlights

Powerful_Enzymatic_Cleaning
Begins breaking down stains immediately and continues until bio-mess is gone.

Versatile_Use_Scenarios
Ideal for multi-pet households, effective on carpets, floors, and fabrics.

Customer_Praised_Sprayer
Battery-powered sprayer offers ease and precision in application.
9.1

Excellent

Our Rating

9.7
potty training

8.9
Odor elimination

8.7
Simple to use
7

Simple Solution
Simple Solution Extreme Pet Stain and Odor Eliminator Spray, Enzymatic Cleaner With 3X Pro-Bacteria Cleaning Power for Dogs & Cats, Strong Urine, Pee and Poop Smell Remover for Carpets & Floors, 32 oz
Main highlights

Powerful Enzymatic Formula
Three times stronger than regular formulas, effectively removes tough pet stains and odors.

Versatile Home Use
Ideal for cleaning dog and cat urine, feces, vomit on carpets, upholstery, and more.

Highly Praised Sprayer
Customers love the improved sprayer for its fine mist and no leakage.
9.0

Excellent

Our Rating

9.7
Odor elimination

9.3
Comfort

9.1
deep clean
8

ACTIVE
Pet Odor and Stain Eliminator - 32 oz ACTIVE Enzyme Cleaner for Dog & Cat Urine, Stain Remover Spray for Carpet, Upholstery, Hardwood, Spot Cleaning, Deodorizer for Dogs Cats Pets - Natural Citrus Oil
Main highlights

Complete Odor and Stain Elimination
The enzyme-based formula effectively removes pet stains and odors, leaving a pleasant citrus scent.

Versatile Home Use
Ideal for cleaning carpets, upholstery, hardwood, and various home surfaces affected by pet messes.

Highly Praised Citrus Scent
Customers appreciate the non-overpowering citrus scent that effectively neutralizes odors.
8.9

Very Good

Our Rating
9

Resolve
Resolve Urine Destroyer Spray – Pet Stain and Odor Remover, Carpet Cleaner Solution for Cat and Dog Urine, 32 Fl Oz
Main highlights

Odor Neutralization and Stain Removal
Neutralizes odors on contact and removes pet and food stains.

Ideal for Households with Pets and Kids
Perfect for carpets, fabrics, and hard surfaces in busy homes.

Customer Praise for Odor Elimination
Praised for effectively reducing odors, even with repeated use.
8.8

Very Good

Our Rating

9.5
Simple to use

9.1
worth the money

8.7
Aroma
10

ACTIVE
Pet Laundry Detergent Odor Remover - ACTIVE Enzyme Based Powder Detergent for Dogs Beds, Cat Pee, HE Washer Friendly Natural Enzymatic Deodorizer, Urine, Smell, Dog Drool, Stain Eliminator - 64 Loads
Main highlights

Powerful Odor and Stain Elimination
ACTIVE Pet Detergent's enzymes tackle pet stains and odors, ensuring fresh results.

Versatile for Pet and Human Laundry
Ideal for pet beds, clothing, and even personal laundry.

Highly Praised Odor Removal
Customers love its ability to remove tough pet odors.
Key specs
- Cleaning Power:Natural cleaning power
- Load Capacity:64 loads
- Formulation:Bio based enzyme cleaner
- Hypoallergenic:Gentle for sensitive skin
- Stain Removal:Targets pesky stains
8.7

Very Good

Our Rating

10 Best dog urine enzymatic cleaners of 2025

1

ANGRY ORANGE Pet Odor Eliminator for Dog and Cat Urine, Carpet Stains, and Strong Smells – Citrus Cleaner with Natural Orange Oil – 24 oz

2

Angry Orange Stain Remover - 32oz Enzyme Pet Cleaner - Dog & Cat Urine Destroyer and Stain Remover - Citrus Spray Cleaning Solution - Puppy Supplies

9.3

8.9

8.7

3

Eco Strong Outdoor Odor Eliminator | Outside Dog Urine Enzyme Cleaner – Powerful Pet, Cat, Animal Scent Deodorizer | Professional Strength for Yard, Turf, Kennels, Patios, Decks (Gallon with Sprayer)

9.1

8.9

8.7

4

KINZUA ENVIRONMENTAL Urine B-Gone, Professional Enzyme Odor Eliminator & Pet Stain Remover, Human, Cat & Dog Urine Cleaner, Effective on Laundry, Carpets & More, Original Scent, 1 Gallon

9.1

8.9

8.4

5

Rocco & Roxie Stain & Odor Eliminator for Strong Odor, 32oz Enzyme Pet Odor Eliminator for Home, Carpet Stain Remover for Cats & Dog Pee, Enzymatic Cat Urine Destroyer, Carpet Cleaner Spray

9.9

9.5

8.9

6

Nature's Miracle Urine Destroyer Plu for Dogs, Enzymatic Formula for Severe Dog Urine Stains, 32 fl oz

9.7

8.9

8.7

7

Simple Solution Extreme Pet Stain and Odor Eliminator Spray, Enzymatic Cleaner With 3X Pro-Bacteria Cleaning Power for Dogs & Cats, Strong Urine, Pee and Poop Smell Remover for Carpets & Floors, 32 oz

9.7

9.3

9.1

8

Pet Odor and Stain Eliminator - 32 oz ACTIVE Enzyme Cleaner for Dog & Cat Urine, Stain Remover Spray for Carpet, Upholstery, Hardwood, Spot Cleaning, Deodorizer for Dogs Cats Pets - Natural Citrus Oil

9

Resolve Urine Destroyer Spray – Pet Stain and Odor Remover, Carpet Cleaner Solution for Cat and Dog Urine, 32 Fl Oz

9.5

9.1

8.7

10

Pet Laundry Detergent Odor Remover - ACTIVE Enzyme Based Powder Detergent for Dogs Beds, Cat Pee, HE Washer Friendly Natural Enzymatic Deodorizer, Urine, Smell, Dog Drool, Stain Eliminator - 64 Loads

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