10 Best digestive enzyme supplements of 2025

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Best Choice

1

Zenwise Health
Zenwise Health Digestive Enzymes for Gut Health & Bloating Relief - Multi Enzymes Digestion Supplement with Probiotics, Bromelain & Papaya for Digestive Health Support - Men & Women - 180 Count
Main highlights

Comprehensive Digestive Support
Combines enzymes, probiotics, and prebiotics for holistic gut health.

Ideal for Sensitive Stomachs
Designed to alleviate bloating, gas, and discomfort pre-meal.

Positive Customer Feedback
Customers appreciate improved digestion and reduced bloating.
Key specs
- Active Ingredients:Turmeric, Ginger, Green Papaya
- Usage:Digestive health
- Formulation:Capsule
- Features:Prebiotic, Probiotic, Vegetarian
- Dosage:1 capsule before meal
9.7

Exceptional

Our Rating

9.9
simple to consume

9.9
Absorbency
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Based on millions of stores and reviews

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Analyzing top stores
Value for Money

2

Physician's CHOICE
Physician's CHOICE Advanced Gut Health Bundle: 60 Billion Probiotics 30ct + Digestive Enzymes 60ct for Digestive, Gut, and Immune Health Supports Occasional Constipation, Diarrhea, Gas, and Bloating
Main highlights

Gut Health and Comfort
Combines 60 billion CFU probiotics and digestive enzymes for optimal gut health and comfort.

Ideal for Digestive Issues
Perfect for supporting digestion, reducing bloating, gas, and indigestion.

Customer Favorite: Digestive Relief
Praised for its effectiveness in relieving digestive discomfort and promoting regularity.
Key specs
- Form:Bundle
- Use:Gut health, nutrient absorption
- Target Symptoms:Digestive discomfort, bloating
- Packaging:Comprehensive gut health solution
- Active Ingredient:Probiotics, Digestive Enzymes
9.6

Exceptional

Our Rating
3

Physician's CHOICE
Physician's CHOICE Digestive Enzymes - Multi Enzymes, Organic Prebiotics & Probiotics for Digestive Health & Gut Health - Meal Time Discomfort Relief & Bloating - Dual Action Approach - 60 CT

15% Off
Main highlights

Comprehensive Digestive Support
Features 16 enzymes, probiotics, and prebiotics for optimal digestion.

Ideal for Meal Time Relief
Perfect for those experiencing bloating or digestive distress post-meals.

Highly Praised for Gut Health
Customers love its effectiveness in supporting gut and digestive health.
Key specs
- Usage:Aid digestion
- Form:Capsules
- Enzyme Blend:16 beneficial enzymes
- Dietary Restrictions:N/A
- Origin:USA
9.5

Excellent

Our Rating
4

NOW Foods
NOW Foods Supplements, Super Enzymes, Formulated with Bromelain, Ox Bile, Pancreatin and Papain,180 Capsules
Main highlights

Supports Healthy Digestion
NOW Super Enzymes blend aids digestion with bromelain, ox bile, pancreatin, and papain.

Ideal for Post-Surgery Recovery
Beneficial for individuals post-gallbladder surgery or with digestive issues.

Highly Praised for Digestive Relief
Customers appreciate its ability to alleviate bloating and discomfort.
Key specs
- Usage:Supports healthy digestion
- Form:Capsule
- Enzyme Blend:Bromelain, ox bile, pancreatin, papain
- Dietary Restrictions:Soy Free, Gluten Free
- Origin:USA
9.3

Excellent

Our Rating

9.7
quality of ingredients

9.5
simple to consume

9.3
worth the money
5

Sports Research
Sports Research Digestive Enzymes with Probiotics & Ginger - Plant Based for Dairy, Protein, Sugar & Carbs - Non-GMO Verified & Vegan Friendly (90 Veggie Capsules)
Main highlights

Complete Gut Wellness Support
15 enzymes with probiotics and ginger for digestion and nutrient absorption.

Ideal for Sensitive Stomachs
Best for those with dietary sensitivities or digestive discomfort.

Highly Praised for Bloating Relief
Users appreciate its effectiveness in reducing bloating and discomfort.
9.2

Excellent

Our Rating

9.9
simple to consume

9.7
worth the money

9.7
Flavor
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6

NewRhythm

NewRhythm Digestive Enzymes 490 mg, with Probiotics & Prebiotic, Plant Based, 7 Key Enzymes, Digestion, Nutrient Absorption, Protease Amylase & Lipase, 120 Vegan Capsules

33% Off
9.0

Excellent

Our Rating
7

Pure Encapsulations
Pure Encapsulations Digestive Enzymes Ultra - Vegetarian Digestive Enzyme Supplement to Support Protein, Carb, Fiber, and Dairy Digestion* - 90 Capsules
Main highlights

Enhanced Nutrient Absorption
Contains vegetarian enzymes to improve nutrient bioavailability and digestion.

Ideal for Digestive Support
Perfect for breaking down proteins, dairy, fiber, and sugars.

Highly Praised for Bloating Relief
Customers frequently commend its effectiveness in reducing bloating.
Key specs
- Usage:Supports digestion
- Form:Capsule
- Enzyme Blend:Vegetarian enzyme blend
- Dietary Restrictions:Free from common allergens
- Origin:N/A
8.8

Very Good

Our Rating

8.9
Flavor

8.4
worth the money
8

Source Naturals
Source Naturals Essential Enzymes 500mg Bio-Aligned Multiple Supplement Herbal Defense for Digestion, Gas & Constipation Relief - Strong Immune System Support* - 120 Capsules

30% Off
Main highlights

Comprehensive Digestive Support
Transforms food into essential nutrients with multiple enzymes for proteins, fats, and carbohydrates.

Versatile Use Cases
Ideal for individuals with digestive issues like bloating or nutrient absorption challenges.

Customer Praised Efficiency
Highly effective in reducing bloating and improving digestion, as noted by users.
8.7

Very Good

Our Rating

9.9
quality of ingredients

9.9
Flavor

9.7
simple to consume
9

Wholesome Wellness
Wholesome Wellness Digestive Enzymes 1000MG Plus Prebiotics & Probiotics Supplement, 180 Capsules, Organic Plant-Based Vegan Formula for Digestion & Lactose with Amylase & Bromelain,3-6 Months Supply

14% Off
Main highlights

Comprehensive Digestive Support
Features 1000 MG of digestive enzymes and 10 billion CFU probiotics for enhanced digestion and gut health.

Ideal for Digestive Challenges
Perfect for those with lactose intolerance or digestive discomfort seeking holistic relief.

Highly Praised Convenience
Replaces multiple supplements, praised for ease of use and effectiveness.
8.6

Very Good

Our Rating

9.9
worth the money

9.7
quality of ingredients

9.5
simple to consume
10

American Health
American Health, Super Papaya Enzyme Plus Chewable Tablets, 360 Count

30% Off
Main highlights

Natural Digestive Support
Contains natural enzymes like papain to aid digestion and nutrient absorption.

Ideal for Digestive Health
Perfect for those with digestive issues, including bloating and post-meal discomfort.

Customer Praised Taste
Highly rated for its pleasant taste and chewable texture.
Key specs
- Usage:After meal supplement
- Form:Chewable
- Enzyme Blend:Natural Digestive Enzyme
- Dietary Restrictions:No gluten, vegetarian
- Origin:N/A
8.5

Good

Our Rating

9.5
simple to consume

9.1
worth the money

8.7
Flavor

10 Best digestive enzyme supplements of 2025

1

Zenwise Health Digestive Enzymes for Gut Health & Bloating Relief - Multi Enzymes Digestion Supplement with Probiotics, Bromelain & Papaya for Digestive Health Support - Men & Women - 180 Count

9.9

9.9

How do we rank?

How do we rank?

Analyzing top stores

2

Physician's CHOICE Advanced Gut Health Bundle: 60 Billion Probiotics 30ct + Digestive Enzymes 60ct for Digestive, Gut, and Immune Health Supports Occasional Constipation, Diarrhea, Gas, and Bloating

3

Physician's CHOICE Digestive Enzymes - Multi Enzymes, Organic Prebiotics & Probiotics for Digestive Health & Gut Health - Meal Time Discomfort Relief & Bloating - Dual Action Approach - 60 CT

4

NOW Foods Supplements, Super Enzymes, Formulated with Bromelain, Ox Bile, Pancreatin and Papain,180 Capsules

9.7

9.5

9.3

5

Sports Research Digestive Enzymes with Probiotics & Ginger - Plant Based for Dairy, Protein, Sugar & Carbs - Non-GMO Verified & Vegan Friendly (90 Veggie Capsules)

9.9

9.7

9.7

6

NewRhythm Digestive Enzymes 490 mg, with Probiotics & Prebiotic, Plant Based, 7 Key Enzymes, Digestion, Nutrient Absorption, Protease Amylase & Lipase, 120 Vegan Capsules

7

Pure Encapsulations Digestive Enzymes Ultra - Vegetarian Digestive Enzyme Supplement to Support Protein, Carb, Fiber, and Dairy Digestion* - 90 Capsules

8.9

8.4

8

Source Naturals Essential Enzymes 500mg Bio-Aligned Multiple Supplement Herbal Defense for Digestion, Gas & Constipation Relief - Strong Immune System Support* - 120 Capsules

9.9

9.9

9.7

9

Wholesome Wellness Digestive Enzymes 1000MG Plus Prebiotics & Probiotics Supplement, 180 Capsules, Organic Plant-Based Vegan Formula for Digestion & Lactose with Amylase & Bromelain,3-6 Months Supply

9.9

9.7

9.5

10

American Health, Super Papaya Enzyme Plus Chewable Tablets, 360 Count

9.5

9.1

8.7

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