10 Best cystic acne spot treatments of 2025

Save up to 35% off

Best Choice

1

Murad
Murad Deep Relief Acne Treatment - Maximum Strength Acne Treatment with 2% Salicylic Acid and Phytosteroid for Deep, Painful Acne Breakouts and Redness - Accelerated Healing Treatment - 1 Fl Oz
Main highlights

Salicylic Acid Power
Contains 2% salicylic acid for effective acne treatment and inflammation reduction.

Best for Cystic Acne
Ideal for treating deep, painful cystic acne on face and body.

User Praised Effectiveness
Praised for reducing acne size and discomfort quickly without excessive dryness.
9.6

Exceptional

Our Rating
How do we rank?

Powerful technology We scan thousands of products and stores, analyzing reviews to find what matters most to users like you

Careful review Our team ensures quality, value, and fit based on real user feedback

Trusted insights AI and human analysis guide your decisions, reflecting real user priorities
Real users impact

Thousands of users trust our site daily

Based on millions of stores and reviews

Shoppers influence our rankings
Analyzing top stores
Value for Money

2

TreeActiv

TreeActiv Cystic Acne Spot Treatment, 2-Pack, Sulfur Spot Treatment, Hormonal Acne Treatment with Tea Tree, Cystic Acne, Blackheads, Cystic Acne Treatment and Pimple Spot Treatment for Face, 240+ Uses
9.5

Excellent

Our Rating
3

TreeActiv
TreeActiv Cystic Acne Spot Treatment, Hormonal & Overnight Sulfur Cystic Treatment For Face, Pimples, and Blemishes for Adults, Men, and Women - 0.5oz 120+ Uses
Main highlights

Key Features
Nature-powered with Bentonite Clay, Sulfur, Tea Tree Oil; FSA/HSA approved; Vegan, cruelty-free; Ideal for all skin types, including sensitive.

Ideal Use Cases
Perfect for treating cystic acne, whiteheads, and blackheads on face and body, including sensitive areas. Works overnight for fast, noticeable results.

Customer Praise
Most reviews highlight its effectiveness in reducing cystic acne quickly, its suitability for sensitive skin, and the long-lasting value of the 0.5oz container.
Key specs
- Skin Type:All skin types
- Effectiveness:Fast results in 20 minutes
- Moisture:Includes Aloe to soothe
- Ingredients:Bentonite Clay, Sulfur, Tea Tree Oil
- Application:Cystic acne treatment
9.3

Excellent

Our Rating

9.5
Fashion

8.9
Easy to use

8.9
Aroma
4

Enaskin Naturals

Acne Pimple Spot Treatment Cream: Cystic Hormonal Blackheads Blemish Breakouts for Face, Back and Body - 10% Azelaic Acid & Salicylic Acid - Teens-Adults, 1.8 oz
9.1

Excellent

Our Rating
5

AcneFree
AcneFree Terminator 10 Acne Spot Treatment with Benzoyl Peroxide 10% Maximum Strength Acne Cream Treatment, 1 Ounce - Pack Of 1

35% Off
Main highlights

Maximum Strength Benzoyl Peroxide
Contains 10% benzoyl peroxide for effective acne treatment and redness control.

Ideal for Spot Treatment
Best used for treating individual pimples and mild recurring acne.

Convenient Flip-Cap Design
Praised for its easy-to-use flip-cap that prevents loss and simplifies application.
Key specs
- Skin Benefits:Redness Control
- Formulation:Cream
- Skin Type:N/A
- Application Frequency:N/A
- Exfoliation Type:N/A
8.9

Very Good

Our Rating

9.7
quality of ingredients

8.4
worth the money

8.0
Sheerness
See Today’s Deals & Prices
6

Differin
Differin Acne Treatment Gel, 30 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 15g Tube (Packaging May Vary)
Main highlights

Effective Acne Treatment
Differin Gel targets clogged pores and inflammation, reducing breakouts and improving skin texture and tone.

Ideal for Acne-Prone Skin
Best for those with acne-prone, sensitive skin needing a gentle retinoid treatment.

Praised for Clear Skin
Customers love its ability to keep skin clear and smooth, even with hormonal or diet-related acne.
8.7

Very Good

Our Rating

8.2
worth the money

8.0
Aroma

8.0
Fashion
7

AYADARA

Cystic Acne Spot Treatment Overnight Hormonal Acne Treatment for Face & Body Sulfur Cream for Women Men & Teens Effective for Stubborn Breakouts 120 Uses

32% Off
8.5

Good

Our Rating
8

Peach Slices
Peach Slices | Deep Blemish Microdarts | Acne Patch | Early Stage & Deep Pimples | Salicylic Acid | Tea Tree Oil | Niacinamide | Cica | Hyaluronic Acid | 9 Patches
Main highlights

Fast_Acting_Acne_Treatment
Quickly absorbs and reduces blemishes with hydrocolloid patches.

Ideal_for_Deep_Blemishes
Perfect for stubborn acne; effective for overnight use.

Highly_Praised_Microdarts
Microdarts are pain-free and enhance treatment efficacy.
Key specs
- Skin Type:All skin types
- Skin Benefits:Fast-acting acne treatment
- Formulation:Hydrocolloid patches
- Application Area:Face
- Active Ingredients:N/A
8.4

Good

Our Rating

8.7
Absorbency

8.0
Sheerness

8.0
Simple to use
9

Neutrogena
Neutrogena Rapid Clear Stubborn Acne Spot Treatment Gel, Maximum Strength 10% Benzoyl Peroxide Treatment Medication for Acne Prone Skin, Pimple Cream Reduces Size & Redness in 2 Hours, 1 oz

27% Off
Main highlights

Maximum Strength Benzoyl Peroxide
Contains 10% benzoyl peroxide for rapid acne reduction.

Ideal for Stubborn Acne
Perfect for treating stubborn acne on acne-prone skin.

Quick and Effective Results
Praised for reducing acne size and redness within hours.
8.3

Good

Our Rating

8.7
Aroma

8.4
Fashion

8.2
worth the money
10

De La Cruz
De La Cruz 10% Sulfur Ointment Travel Size - Cystic Acne Treatment for Face and Body - Daily 10 Min Spot Treatment Mask Safe and Effective Game Changing Hormonal Acne Treatment 0.21oz 6g
Main highlights

Fast Action Sulfur Cream
Noticeable acne and skin improvement in days; smooth, blemish-free results.

Ideal for Cystic Acne
Best for hormonal and severe acne on face and body.

Effective Spot Treatment
Praised for reducing breakouts quickly with minimal odor.
8.0

Good

Our Rating

10 Best cystic acne spot treatments of 2025

1

Murad Deep Relief Acne Treatment - Maximum Strength Acne Treatment with 2% Salicylic Acid and Phytosteroid for Deep, Painful Acne Breakouts and Redness - Accelerated Healing Treatment - 1 Fl Oz

How do we rank?

How do we rank?

Analyzing top stores

2

TreeActiv Cystic Acne Spot Treatment, 2-Pack, Sulfur Spot Treatment, Hormonal Acne Treatment with Tea Tree, Cystic Acne, Blackheads, Cystic Acne Treatment and Pimple Spot Treatment for Face, 240+ Uses

3

TreeActiv Cystic Acne Spot Treatment, Hormonal & Overnight Sulfur Cystic Treatment For Face, Pimples, and Blemishes for Adults, Men, and Women - 0.5oz 120+ Uses

9.5

8.9

8.9

4

Acne Pimple Spot Treatment Cream: Cystic Hormonal Blackheads Blemish Breakouts for Face, Back and Body - 10% Azelaic Acid & Salicylic Acid - Teens-Adults, 1.8 oz

5

AcneFree Terminator 10 Acne Spot Treatment with Benzoyl Peroxide 10% Maximum Strength Acne Cream Treatment, 1 Ounce - Pack Of 1

9.7

8.4

8.0

6

Differin Acne Treatment Gel, 30 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 15g Tube (Packaging May Vary)

8.2

8.0

8.0

7

Cystic Acne Spot Treatment Overnight Hormonal Acne Treatment for Face & Body Sulfur Cream for Women Men & Teens Effective for Stubborn Breakouts 120 Uses

8

Peach Slices | Deep Blemish Microdarts | Acne Patch | Early Stage & Deep Pimples | Salicylic Acid | Tea Tree Oil | Niacinamide | Cica | Hyaluronic Acid | 9 Patches

8.7

8.0

8.0

9

Neutrogena Rapid Clear Stubborn Acne Spot Treatment Gel, Maximum Strength 10% Benzoyl Peroxide Treatment Medication for Acne Prone Skin, Pimple Cream Reduces Size & Redness in 2 Hours, 1 oz

8.7

8.4

8.2

10

De La Cruz 10% Sulfur Ointment Travel Size - Cystic Acne Treatment for Face and Body - Daily 10 Min Spot Treatment Mask Safe and Effective Game Changing Hormonal Acne Treatment 0.21oz 6g

Sign up and get exclusive special deals