10 Best cystic acne spot treatments of 2026

Save up to 52% off

1

TreeActiv
TreeActiv Cystic Acne Spot Treatment, Hormonal & Overnight Sulfur Cystic Treatment For Face, Pimples, and Blemishes for Adults, Men, and Women - 0.5oz 120+ Uses

26% Off
Main highlights

Key Features
Nature-powered with Bentonite Clay, Sulfur, Tea Tree Oil; FSA/HSA approved; Vegan, cruelty-free; Ideal for all skin types, including sensitive.

Ideal Use Cases
Perfect for treating cystic acne, whiteheads, and blackheads on face and body, including sensitive areas. Works overnight for fast, noticeable results.

Customer Praise
Most reviews highlight its effectiveness in reducing cystic acne quickly, its suitability for sensitive skin, and the long-lasting value of the 0.5oz container.
Key specs
- Effectiveness:Fast results in 20 minutes
- Moisture:Includes Aloe to soothe
- Ingredients:Bentonite Clay, Sulfur, Tea Tree Oil
- Application:Cystic acne treatment
- Skin Benefits:N/A
9.7

Exceptional

Our Rating

9.5
Fashion

8.9
Easy to use

8.9
Aroma
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2

TreeActiv
TreeActiv Cystic Acne Spot Treatment, Hormonal & Overnight Sulfur Cystic Treatment For Face, Pimples, and Blemishes for Adults, Men, and Women - 0.5oz 120+ Uses

30% Off
Main highlights

Key Features
Nature-powered with Bentonite Clay, Sulfur, Tea Tree Oil; FSA/HSA approved; Vegan, cruelty-free; Ideal for all skin types, including sensitive.

Ideal Use Cases
Perfect for treating cystic acne, whiteheads, and blackheads on face and body, including sensitive areas. Works overnight for fast, noticeable results.

Customer Praise
Most reviews highlight its effectiveness in reducing cystic acne quickly, its suitability for sensitive skin, and the long-lasting value of the 0.5oz container.
Key specs
- Effectiveness:Fast results in 20 minutes
- Moisture:Includes Aloe to soothe
- Ingredients:Bentonite Clay, Sulfur, Tea Tree Oil
- Application:Cystic acne treatment
- Skin Benefits:N/A
9.5

Excellent

Our Rating

9.5
Fashion

8.9
Easy to use

8.9
Aroma
3

AcneFree
AcneFree Terminator 10 Acne Spot Treatment with Benzoyl Peroxide 10% Maximum Strength Acne Cream Treatment, 1 Ounce - Pack Of 1

32% Off
Main highlights

Maximum Strength Benzoyl Peroxide
Contains 10% benzoyl peroxide for effective acne treatment and redness control.

Ideal for Spot Treatment
Best used for treating individual pimples and mild recurring acne.

Convenient Flip-Cap Design
Praised for its easy-to-use flip-cap that prevents loss and simplifies application.
9.3

Excellent

Our Rating

9.7
quality of ingredients

8.4
worth the money

8.0
Sheerness
4

AcneFree
AcneFree Terminator 10 Acne Spot Treatment with Benzoyl Peroxide 10% Maximum Strength Acne Cream Treatment, 1 Ounce - Pack Of 1

35% Off
Main highlights

Maximum Strength Benzoyl Peroxide
Contains 10% benzoyl peroxide for effective acne treatment and redness control.

Ideal for Spot Treatment
Best used for treating individual pimples and mild recurring acne.

Convenient Flip-Cap Design
Praised for its easy-to-use flip-cap that prevents loss and simplifies application.
9.1

Excellent

Our Rating

9.7
quality of ingredients

8.4
worth the money

8.0
Sheerness
5

The Ordinary

The Ordinary Sulfur 10% Powder-to-Cream Acne Spot Treatment Concentrate, Reduces Pimple Size and Zit Redness, 0.18 Oz
8.9

Very Good

Our Rating
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6

The Ordinary

The Ordinary Sulfur 10% Powder-to-Cream Acne Spot Treatment Concentrate, Reduces Pimple Size and Zit Redness, 0.18 Oz
8.7

Very Good

Our Rating
7

Kempc

Cystic Acne Treatment for Face – Hormonal Acne Spot Treatment Pimple Cream with Azelaic Acid | Redness Reducing Acne Moisturizer for Rosacea & Sensitive, Acne-Prone Skin | Teens & Adults, 1.7 oz

52% Off
8.5

Good

Our Rating
8

Kempc

Cystic Acne Treatment for Face – Hormonal Acne Spot Treatment Pimple Cream with Azelaic Acid | Redness Reducing Acne Moisturizer for Rosacea & Sensitive, Acne-Prone Skin | Teens & Adults, 1.7 oz

52% Off
8.3

Good

Our Rating
9

De La Cruz
De La Cruz 10% Sulfur Ointment - Cystic Acne Treatment for Face and Body - Daily 10 Min Spot Treatment Mask - Safe and Effective Game Changing Hormonal Acne Treatment That Clears Up Pimples - 2.6 oz

10% Off
Main highlights

Fast Acne Reduction
Experience smoother, blemish-free skin with fast-acting sulfur cream, reducing acne within days.

Versatile Application
Ideal for treating hormonal, cystic acne, blackheads, and acne scars on all skin types.

Customer Praised Effectiveness
Highly effective in preventing new pimples and blackheads from forming, as noted by users.
Key specs
- Skin Type:All skin types
- Application Frequency:Daily
- Skin Benefits:Blemish-free, smooth skin
- Results Duration:Few days
- Formulation:Ointment
8.2

Good

Our Rating
10

De La Cruz
De La Cruz 10% Sulfur Ointment - Cystic Acne Treatment for Face and Body - Daily 10 Min Spot Treatment Mask - Safe and Effective Game Changing Hormonal Acne Treatment That Clears Up Pimples - 2.6 oz

15% Off
Main highlights

Fast Acne Reduction
Experience smoother, blemish-free skin with fast-acting sulfur cream, reducing acne within days.

Versatile Application
Ideal for treating hormonal, cystic acne, blackheads, and acne scars on all skin types.

Customer Praised Effectiveness
Highly effective in preventing new pimples and blackheads from forming, as noted by users.
Key specs
- Skin Type:All skin types
- Application Frequency:Daily
- Skin Benefits:Blemish-free, smooth skin
- Results Duration:Few days
- Formulation:Ointment
8.1

Good

Our Rating

10 Best cystic acne spot treatments of 2026

1

TreeActiv Cystic Acne Spot Treatment, Hormonal & Overnight Sulfur Cystic Treatment For Face, Pimples, and Blemishes for Adults, Men, and Women - 0.5oz 120+ Uses

9.5

8.9

8.9

How do we rank?

How do we rank?

Analyzing top stores

2

TreeActiv Cystic Acne Spot Treatment, Hormonal & Overnight Sulfur Cystic Treatment For Face, Pimples, and Blemishes for Adults, Men, and Women - 0.5oz 120+ Uses

9.5

8.9

8.9

3

AcneFree Terminator 10 Acne Spot Treatment with Benzoyl Peroxide 10% Maximum Strength Acne Cream Treatment, 1 Ounce - Pack Of 1

9.7

8.4

8.0

4

AcneFree Terminator 10 Acne Spot Treatment with Benzoyl Peroxide 10% Maximum Strength Acne Cream Treatment, 1 Ounce - Pack Of 1

9.7

8.4

8.0

5

The Ordinary Sulfur 10% Powder-to-Cream Acne Spot Treatment Concentrate, Reduces Pimple Size and Zit Redness, 0.18 Oz

6

The Ordinary Sulfur 10% Powder-to-Cream Acne Spot Treatment Concentrate, Reduces Pimple Size and Zit Redness, 0.18 Oz

7

Cystic Acne Treatment for Face – Hormonal Acne Spot Treatment Pimple Cream with Azelaic Acid | Redness Reducing Acne Moisturizer for Rosacea & Sensitive, Acne-Prone Skin | Teens & Adults, 1.7 oz

8

Cystic Acne Treatment for Face – Hormonal Acne Spot Treatment Pimple Cream with Azelaic Acid | Redness Reducing Acne Moisturizer for Rosacea & Sensitive, Acne-Prone Skin | Teens & Adults, 1.7 oz

9

De La Cruz 10% Sulfur Ointment - Cystic Acne Treatment for Face and Body - Daily 10 Min Spot Treatment Mask - Safe and Effective Game Changing Hormonal Acne Treatment That Clears Up Pimples - 2.6 oz

10

De La Cruz 10% Sulfur Ointment - Cystic Acne Treatment for Face and Body - Daily 10 Min Spot Treatment Mask - Safe and Effective Game Changing Hormonal Acne Treatment That Clears Up Pimples - 2.6 oz

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