July 22, 2025

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10 Best cat urine cleaner enzymes of 2025

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Best Choice

1

AmazonCommercial
AmazonCommercial Multi-Purpose Enzyme Cleaner, 1-Gallon, 1-Pack
Main highlights

Powerful Enzymatic Cleaning
Breaks down complex organic proteins, pet stains, and odors on various surfaces.

Ideal for Pet Owners
Perfect for homes with pets, tackling messes on carpets, furniture, and more.

Highly Praised Odor Elimination
Customers love its ability to eliminate odors, not just mask them.
9.9

Exceptional

Our Rating

9.3
Simple to use

9.1
worth the money

8.9
Odor elimination
How do we rank?

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Based on millions of stores and reviews

Shoppers influence our rankings
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Value for Money

2

Bioda
Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon
Main highlights

Powerful Cleaning and Odor Control
This probiotic cleaner offers powerful cleaning and odor elimination for various surfaces, leaving a fresh lemon and sage scent.

Ideal for Pet and Household Use
Perfect for managing pet stains, odors, and maintaining household cleanliness, especially in bathrooms and kitchens.

Highly Effective Odor Elimination
Customers praise its ability to permanently eliminate tough odors, especially from pet-related incidents and organic waste.
Key specs
- volume:1 Gallon
- cleaning method:Probiotic cleaner
- scent:Lemon and sage
- specific instructions:Spray & let probiotics work
- perfume:Lemon and sage
9.8

Exceptional

Our Rating
3

Nature's Miracle
Nature's Miracle Urine Destroyer Plus for Cats, Enzymatic Formula for Severe Cat Urine Stains, 32 oz

15% Off
Main highlights

Powerful Stain and Odor Removal
Enzymatic formula breaks down severe cat urine stains and odors.

Ideal for Persistent Pet Messes
Perfect for cleaning carpets, furniture, and litter box areas.

Highly Effective Odor Control
Praised for eliminating smells, preventing repeat pet marking.
9.6

Exceptional

Our Rating

9.7
Freshness

9.3
Simple to use

8.4
worth the money
4

Rocco & Roxie Supply Co.
Rocco & Roxie Stain & Odor Eliminator for Strong Odor, 32oz Enzyme Pet Odor Eliminator for Home, Carpet Stain Remover for Cats & Dog Pee, Enzymatic Cat Urine Destroyer, Carpet Cleaner Spray
Main highlights

Certified Safe and Effective
Chlorine-free, color-safe, and CRI-approved for all carpets.

Ideal for Pet Owners
Perfect for removing pet stains and odors from multiple surfaces.

Enzyme-Based Miracle Worker
Customer reviews praise its ability to eliminate odors completely.
9.5

Excellent

Our Rating

9.9
worth the money

9.5
Simple to use

8.9
Odor elimination
5

Nature's Miracle
Nature's Miracle Advanced Cat Stain and Odor Eliminator Spray, Severe Mess Enzymatic Formula, 32 fl oz

15% Off
Main highlights

Powerful Enzymatic Formula
Eliminates tough stains and odors from cat messes effectively.

Ideal for Severe Cat Messes
Perfect for handling urine, diarrhea, vomit, and bio-based accidents.

Highly Praised Odor Control
Customers love the fresh scent and effective odor removal.
9.3

Excellent

Our Rating

9.9
Odor elimination

9.3
Simple to use

8.7
Aroma
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6

Nature's Miracle
Nature's Miracle Urine Destroyer Plus for Cats, Enzymatic Formula for Severe Cat Urine Stains, 17.5 oz

15% Off
Main highlights

Powerful Enzymatic Formula
Tough on strong cat urine, eliminates odors and sticky residue.

Ideal for Severe Stains
Best used for tough cat urine stains on carpets and furniture.

Highly Effective Odor Removal
Customers praise its ability to completely remove urine smell.
9.1

Excellent

Our Rating

9.7
Freshness

9.3
Simple to use

9.1
Odor elimination
7

Simple Solution
Simple Solution Extreme Pet Stain and Odor Eliminator Spray, Enzymatic Cleaner With 3X Pro-Bacteria Cleaning Power for Dogs & Cats, Strong Urine, Pee and Poop Smell Remover for Carpets & Floors, 32 oz
Main highlights

Powerful Enzymatic Formula
Three times stronger than regular formulas, effectively removes tough pet stains and odors.

Versatile Home Use
Ideal for cleaning dog and cat urine, feces, vomit on carpets, upholstery, and more.

Highly Praised Sprayer
Customers love the improved sprayer for its fine mist and no leakage.
9.0

Excellent

Our Rating

9.7
Odor elimination

9.3
Comfort

9.1
deep clean
8

Resolve
Resolve Urine Destroyer Spray – Pet Stain and Odor Remover, Carpet Cleaner Solution for Cat and Dog Urine, 32 Fl Oz
Main highlights

Odor Neutralization and Stain Removal
Neutralizes odors on contact and removes pet and food stains.

Ideal for Households with Pets and Kids
Perfect for carpets, fabrics, and hard surfaces in busy homes.

Customer Praise for Odor Elimination
Praised for effectively reducing odors, even with repeated use.
8.9

Very Good

Our Rating

9.5
Simple to use

9.1
worth the money

8.7
Aroma
9

ACTIVE
Pet Odor and Stain Eliminator - 32 oz ACTIVE Enzyme Cleaner for Dog & Cat Urine, Stain Remover Spray for Carpet, Upholstery, Hardwood, Spot Cleaning, Deodorizer for Dogs Cats Pets - Natural Citrus Oil
Main highlights

Complete Odor and Stain Elimination
The enzyme-based formula effectively removes pet stains and odors, leaving a pleasant citrus scent.

Versatile Home Use
Ideal for cleaning carpets, upholstery, hardwood, and various home surfaces affected by pet messes.

Highly Praised Citrus Scent
Customers appreciate the non-overpowering citrus scent that effectively neutralizes odors.
8.8

Very Good

Our Rating
10

Simple Green
Cat Stain & Odor Remover - Enzyme Cleaner for Cat Urine, Feces, Blood, Vomit - 32oz

15% Off
Main highlights

Powerful Enzyme Action
Uses natural enzymes to eliminate odors and stains at the source.

Versatile Use Cases
Ideal for carpets, upholstery, pet bedding, and more.

Fresh Scent Praised
Customers love the fresh, clean scent after use.
8.6

Very Good

Our Rating

9.1
Simple to use

8.4
Aroma

8.2
worth the money

10 Best cat urine cleaner enzymes of 2025

1

AmazonCommercial Multi-Purpose Enzyme Cleaner, 1-Gallon, 1-Pack

9.3

9.1

8.9

How do we rank?

How do we rank?

Analyzing top stores

2

Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon

3

Nature's Miracle Urine Destroyer Plus for Cats, Enzymatic Formula for Severe Cat Urine Stains, 32 oz

9.7

9.3

8.4

4

Rocco & Roxie Stain & Odor Eliminator for Strong Odor, 32oz Enzyme Pet Odor Eliminator for Home, Carpet Stain Remover for Cats & Dog Pee, Enzymatic Cat Urine Destroyer, Carpet Cleaner Spray

9.9

9.5

8.9

5

Nature's Miracle Advanced Cat Stain and Odor Eliminator Spray, Severe Mess Enzymatic Formula, 32 fl oz

9.9

9.3

8.7

6

Nature's Miracle Urine Destroyer Plus for Cats, Enzymatic Formula for Severe Cat Urine Stains, 17.5 oz

9.7

9.3

9.1

7

Simple Solution Extreme Pet Stain and Odor Eliminator Spray, Enzymatic Cleaner With 3X Pro-Bacteria Cleaning Power for Dogs & Cats, Strong Urine, Pee and Poop Smell Remover for Carpets & Floors, 32 oz

9.7

9.3

9.1

8

Resolve Urine Destroyer Spray – Pet Stain and Odor Remover, Carpet Cleaner Solution for Cat and Dog Urine, 32 Fl Oz

9.5

9.1

8.7

9

Pet Odor and Stain Eliminator - 32 oz ACTIVE Enzyme Cleaner for Dog & Cat Urine, Stain Remover Spray for Carpet, Upholstery, Hardwood, Spot Cleaning, Deodorizer for Dogs Cats Pets - Natural Citrus Oil

10

Cat Stain & Odor Remover - Enzyme Cleaner for Cat Urine, Feces, Blood, Vomit - 32oz

9.1

8.4

8.2

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