10 Best butyrate supplements of 2025

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1

Tesseract Medical Research
Tesseract Medical Research ProButyrate Gut Health Supplement, Butyric Acid Complex, Gastrointestinal Support Supplement, Helps Restore Balance to Stabilize Gut Microbiome, 600mg, 120 Capsules
Main highlights

Sustained Release Butyric Acid
Formulated with butyric acid in a sustained-release format for enhanced gut health.

Gut Microbiome Stabilization
Ideal for stabilizing and restoring balance in the gut microbiome.

Positive Gut Health Impact
Customers appreciate its positive impact on gut health and well-being.
Key specs
- Form:Sustained-release
- Ingredients:Butyric Acid
- Benefits:Gut health support
- Gluten-Free:N/A
- Capsules:N/A
9.8

Exceptional

Our Rating

8.7
worth the money

8.2
Flavor
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Value for Money

2

Designs for Health
Designs for Health Tri-Butyrin Supreme - 3-in-1 Butyric Acid (Butyrate) Postbiotics for Gut Health & Gut Permeability Support - Tributyrin Supplement with Odor-Minimizing Innovation (60 Softgels)
Main highlights

Supports Gut and Immune Health
Contains Tributyrin, a triple butyrate compound, supporting gut flora and immune function.

Ideal for Gut Permeability Issues
Best used by those suffering from gut permeability and related issues.

Easy to Swallow Softgels
Customers praise the small, easy-to-swallow softgel format.
Key specs
- Form:Capsules
- Ingredients:Butyrate, Tributyrin, Glycerol
- Benefits:Promotes colon health
- Gluten-Free:Yes
- Capsules:N/A
9.6

Exceptional

Our Rating

9.5
simple to consume

8.0
Flavor

8.0
worth the money
3

BodyBio
BodyBio Sodium Butyrate - Postbiotic for Gut Health, Leaky Gut Repair, Digestive Support, Bloating Relief, & Microbiome Balance - Butyric Acid Supplement for GI Wellness
Main highlights

Supports Digestive Health
Butyrate enhances probiotics, promoting gut health and regularity.

Ideal for Weight Loss
Assists in detoxification and promotes healthy weight management.

Praised for Gut Benefits
Customers report improved gut health and regularity.
9.3

Excellent

Our Rating

9.7
quality of ingredients

9.3
Comfort

9.1
Simple to use
4

LongJuvity Labs
LongJuvity Sodium Butyrate Supplement (300mg) - Naturally Sourced Postbiotic - Optimal Gut Health & Leaky Gut Repair - Postbiotic Short Chain Fatty Acid, Lab Tested (120 Extended Release Caps)
Main highlights

Extended Release Micro-Granules
Ensures sodium butyrate reaches the lower gastrointestinal tract for optimal absorption.

Ideal for Digestive Health
Perfect for those seeking enhanced gut health and digestion support.

Praised Timed Release Feature
Customers love the gradual release ensuring consistent nutrient delivery.
Key specs
- Form:Micro-encapsulated granules
- Ingredients:Sodium Butyrate
- Benefits:Extended release granules
- Gluten-Free:N/A
- Capsules:N/A
9.2

Excellent

Our Rating
5

Doctor's BEST

Doctor's BEST High Absorption Postbiotic Butyrate Featuring Corebiome, Gut & Immune Health, Non-GMO, Gluten Free, Soy Free, Vegan, 30 Liquid Veggie Caps
9.0

Excellent

Our Rating
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6

BodyBio
BodyBio Calcium Magnesium Butyrate - Postbiotic for Gut Health, Leaky Gut Repair, Digestive Support, Bloating Relief, & Microbiome Balance - Butyric Acid Supplement for GI Wellness
Main highlights

Supports Gut Health and Digestion
BodyBio Butyrate aids in digestion, enhances microbiome diversity, and supports gut health with calcium and magnesium buffering acids.

Ideal for Gut Disorders and Detoxification
Recommended for fibromyalgia, pancreatitis, and gut detoxification, promoting a healthier gut biome and reducing inflammation.

Praised for Reducing Bloating and Gas
Customers frequently highlight its effectiveness in eliminating bloating, gas, and improving overall gut comfort.
8.9

Very Good

Our Rating

8.0
worth the money

8.0
Comfort

8.0
Flavor
7

Nextdia
Butyrate Gummies with Probiotic + Prebiotic + Postbiotic, Omega-3 500mg,Fiber with 9 Billion CFU Probiotics, Calcium & Magnesium, Inulin,Psyllium Husk for Digestive Health,Bloating Support,Sugar Free
Main highlights

Digestive Health Support
Combines probiotics, prebiotics, and postbiotics for optimal gut health.

Ideal for Daily Use
Perfect for those seeking a sugar-free, gut health supplement.

Praised for Taste and Texture
Customers love the peach flavor and soft, chewy texture.
Key specs
- CFU:9 Billion
- Form:Liquid Filled Gummies
- Strains:L. acidophilus, L. rhamnosus
- Gluten Free:Yes
- Features:Sugar free, Non-GMO
8.8

Very Good

Our Rating
8

Allergy Research Group
Allergy Research Group ButyrEn - Butyrate Gut Health Supplement for Women and Men, Colon and Digestive Support with Tributyrate Complex, Butyric Acid - 100 Delayed Release Vegetarian Capsules
Main highlights

Gastric Acid-Resistant Formulation
MUCOSAL INTEGRITY SUPPORT - Promotes colon health with butyric acid; vegetarian, gluten-free.

Ideal for Digestive Health Support
Perfect for those with digestive issues or leaky gut.

Customer Praised Effectiveness
Highly effective for digestive health, praised for improving gut issues.
Key specs
- Form:Capsule
- Ingredients:Butyric acid, calcium, magnesium
- Benefits:Promotes colon health
- Gluten-Free:Yes
- Capsules:Vegetarian
8.7

Very Good

Our Rating
9

NICMIN

NICMIN Tributyrin Supplement - Premium Butyrate Gut Health Supplement for Leaky Gut 60 Capsules
8.6

Very Good

Our Rating
10

Nutricost
Nutricost HMB (Beta-Hydroxy Beta-Methylbutyrate) 1000mg (240 Capsules) - 500mg Per Capsule, 120 Servings - Gluten Free and Non-GMO
Main highlights

High Potency Formula
Each serving provides 1000mg of HMB, supporting muscle growth and recovery.

Convenient for Active Lifestyles
Ideal for those seeking muscle maintenance with minimal exercise routines.

Positive User Feedback on Energy
Users report increased energy and muscle definition with regular use.
8.5

Good

Our Rating

9.7
simple to consume

9.3
worth the money

8.7
quality of ingredients

10 Best butyrate supplements of 2025

1

Tesseract Medical Research ProButyrate Gut Health Supplement, Butyric Acid Complex, Gastrointestinal Support Supplement, Helps Restore Balance to Stabilize Gut Microbiome, 600mg, 120 Capsules

8.7

8.2

How do we rank?

How do we rank?

Analyzing top stores

2

Designs for Health Tri-Butyrin Supreme - 3-in-1 Butyric Acid (Butyrate) Postbiotics for Gut Health & Gut Permeability Support - Tributyrin Supplement with Odor-Minimizing Innovation (60 Softgels)

9.5

8.0

8.0

3

BodyBio Sodium Butyrate - Postbiotic for Gut Health, Leaky Gut Repair, Digestive Support, Bloating Relief, & Microbiome Balance - Butyric Acid Supplement for GI Wellness

9.7

9.3

9.1

4

LongJuvity Sodium Butyrate Supplement (300mg) - Naturally Sourced Postbiotic - Optimal Gut Health & Leaky Gut Repair - Postbiotic Short Chain Fatty Acid, Lab Tested (120 Extended Release Caps)

5

Doctor's BEST High Absorption Postbiotic Butyrate Featuring Corebiome, Gut & Immune Health, Non-GMO, Gluten Free, Soy Free, Vegan, 30 Liquid Veggie Caps

6

BodyBio Calcium Magnesium Butyrate - Postbiotic for Gut Health, Leaky Gut Repair, Digestive Support, Bloating Relief, & Microbiome Balance - Butyric Acid Supplement for GI Wellness

8.0

8.0

8.0

7

Butyrate Gummies with Probiotic + Prebiotic + Postbiotic, Omega-3 500mg,Fiber with 9 Billion CFU Probiotics, Calcium & Magnesium, Inulin,Psyllium Husk for Digestive Health,Bloating Support,Sugar Free

8

Allergy Research Group ButyrEn - Butyrate Gut Health Supplement for Women and Men, Colon and Digestive Support with Tributyrate Complex, Butyric Acid - 100 Delayed Release Vegetarian Capsules

9

NICMIN Tributyrin Supplement - Premium Butyrate Gut Health Supplement for Leaky Gut 60 Capsules

10

Nutricost HMB (Beta-Hydroxy Beta-Methylbutyrate) 1000mg (240 Capsules) - 500mg Per Capsule, 120 Servings - Gluten Free and Non-GMO

9.7

9.3

8.7

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