10 Best blemish spot treatments of 2026

Save up to 35% off

1

Mighty Patch
Mighty Patch Original Patch from Hero Cosmetics - #1 Hydrocolloid Acne Pimple Patches for Face, Shrinking Zits & Whiteheads in 1 Use, Nighttime Spot Pimple Stickers for Face, 36 Count
Main highlights

Overnight Pimple Treatment
Mighty Patch Original uses hydrocolloid to visibly improve pimples overnight, reducing redness and size.

Best for Night Use
Ideal for overnight use, these patches stay on securely while you sleep.

Customer Praised Adhesion
Customers love the strong adhesion that keeps the patch in place all night.
9.8

Exceptional

Our Rating

9.5
Simple to use

9.5
Simple to take off

9.5
Attachment
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2

Mighty Patch
Mighty Patch Original Patch from Hero Cosmetics - #1 Hydrocolloid Acne Pimple Patches for Face, Shrinking Zits & Whiteheads in 1 Use, Nighttime Spot Pimple Stickers for Face, 36 Count

10% Off
Main highlights

Overnight Pimple Treatment
Mighty Patch Original uses hydrocolloid to visibly improve pimples overnight, reducing redness and size.

Best for Night Use
Ideal for overnight use, these patches stay on securely while you sleep.

Customer Praised Adhesion
Customers love the strong adhesion that keeps the patch in place all night.
9.7

Exceptional

Our Rating

9.5
Simple to use

9.5
Simple to take off

9.5
Attachment
3

Amazon Basics
Amazon Basics Advanced Blemish Spot Treatment with 2% Salicylic Acid Acne Medication, 0.75 Fluid Ounces, 1-Pack
Main highlights

Advanced Acne Treatment
Formulated with 2% Salicylic Acid to effectively treat acne.

Targeted Spot Application
Ideal for applying on specific blemishes one to three times daily.

High Volume Tube
Praised for containing a generous amount of product.
Key specs
- Application Frequency:One to three times daily
- Skin Benefits:Acne treatment
- Formulation:Spot treatment
- Active Ingredient:2% Salicylic Acid
- Skin Type:N/A
9.5

Excellent

Our Rating
4

Amazon Basics
Amazon Basics Advanced Blemish Spot Treatment with 2% Salicylic Acid Acne Medication, 0.75 Fluid Ounces, 1-Pack
Main highlights

Advanced Acne Treatment
Formulated with 2% Salicylic Acid to effectively treat acne.

Targeted Spot Application
Ideal for applying on specific blemishes one to three times daily.

High Volume Tube
Praised for containing a generous amount of product.
Key specs
- Application Frequency:One to three times daily
- Skin Benefits:Acne treatment
- Formulation:Spot treatment
- Active Ingredient:2% Salicylic Acid
- Skin Type:N/A
9.3

Excellent

Our Rating
5

Neutrogena
Neutrogena On-The-Spot Acne Spot Treatment Cream with 2.5% Benzoyl Peroxide, Gentle Face Blemish Medicine for Acne-Prone Skin, Vanishing Formula, Clinically Proven Day-1 Results, 0.75-Ounce Tube

17% Off
Main highlights

Effective Acne Treatment with Benzoyl Peroxide
.75-ounce tube with 2.5% benzoyl peroxide fights acne gently.

Ideal for Daily Use on Acne-Prone Skin
Use up to three times daily without over-drying.

Praised for Quick and Visible Results
Customers appreciate its effectiveness and quick results.
Key specs
- Skin Type:All skin types
- Formulation:Cream
- Effects:Fights acne
- Niacinamide:N/A
- Hyaluronic Acid:N/A
9.1

Excellent

Our Rating
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6

Neutrogena
Neutrogena On-The-Spot Acne Spot Treatment Cream with 2.5% Benzoyl Peroxide, Gentle Face Blemish Medicine for Acne-Prone Skin, Vanishing Formula, Clinically Proven Day-1 Results, 0.75-Ounce Tube

21% Off
Main highlights

Effective Acne Treatment with Benzoyl Peroxide
.75-ounce tube with 2.5% benzoyl peroxide fights acne gently.

Ideal for Daily Use on Acne-Prone Skin
Use up to three times daily without over-drying.

Praised for Quick and Visible Results
Customers appreciate its effectiveness and quick results.
Key specs
- Skin Type:All skin types
- Formulation:Cream
- Effects:Fights acne
- Niacinamide:N/A
- Hyaluronic Acid:N/A
8.9

Very Good

Our Rating
7

The Ordinary
The Ordinary Salicylic Acid 2% Solution, Acne-Fighting Serum for Blemish-Prone Skin, 1 Fl Oz
Main highlights

Blemish-Reduction Formula
The Ordinary Salicylic Acid 2% Solution targets acne and blemishes effectively.

Ideal for Oily Skin
Best used for oily and blemish-prone skin types.

Customer Praised Clarity
Users frequently commend its ability to clear skin blemishes.
8.6

Very Good

Our Rating
8

The Ordinary
The Ordinary Salicylic Acid 2% Solution, Acne-Fighting Serum for Blemish-Prone Skin, 1 Fl Oz
Main highlights

Blemish-Reduction Formula
The Ordinary Salicylic Acid 2% Solution targets acne and blemishes effectively.

Ideal for Oily Skin
Best used for oily and blemish-prone skin types.

Customer Praised Clarity
Users frequently commend its ability to clear skin blemishes.
8.3

Good

Our Rating
9

AcneFree
AcneFree Terminator 10 Acne Spot Treatment with Benzoyl Peroxide 10% Maximum Strength Acne Cream Treatment, 1 Ounce - Pack Of 1

32% Off
Main highlights

Maximum Strength Benzoyl Peroxide
Contains 10% benzoyl peroxide for effective acne treatment and redness control.

Ideal for Spot Treatment
Best used for treating individual pimples and mild recurring acne.

Convenient Flip-Cap Design
Praised for its easy-to-use flip-cap that prevents loss and simplifies application.
Key specs
- Skin Benefits:Redness Control
- Formulation:Cream
- Skin Type:N/A
- Application Frequency:N/A
- Exfoliation Type:N/A
8.1

Good

Our Rating

9.7
quality of ingredients

8.4
worth the money

8.0
Sheerness
10

AcneFree
AcneFree Terminator 10 Acne Spot Treatment with Benzoyl Peroxide 10% Maximum Strength Acne Cream Treatment, 1 Ounce - Pack Of 1

35% Off
Main highlights

Maximum Strength Benzoyl Peroxide
Contains 10% benzoyl peroxide for effective acne treatment and redness control.

Ideal for Spot Treatment
Best used for treating individual pimples and mild recurring acne.

Convenient Flip-Cap Design
Praised for its easy-to-use flip-cap that prevents loss and simplifies application.
Key specs
- Skin Benefits:Redness Control
- Formulation:Cream
- Skin Type:N/A
- Application Frequency:N/A
- Exfoliation Type:N/A
7.9

Good

Our Rating

9.7
quality of ingredients

8.4
worth the money

8.0
Sheerness

10 Best blemish spot treatments of 2026

1

Mighty Patch Original Patch from Hero Cosmetics - #1 Hydrocolloid Acne Pimple Patches for Face, Shrinking Zits & Whiteheads in 1 Use, Nighttime Spot Pimple Stickers for Face, 36 Count

9.5

9.5

9.5

How do we rank?

How do we rank?

Analyzing top stores

2

Mighty Patch Original Patch from Hero Cosmetics - #1 Hydrocolloid Acne Pimple Patches for Face, Shrinking Zits & Whiteheads in 1 Use, Nighttime Spot Pimple Stickers for Face, 36 Count

9.5

9.5

9.5

3

Amazon Basics Advanced Blemish Spot Treatment with 2% Salicylic Acid Acne Medication, 0.75 Fluid Ounces, 1-Pack

4

Amazon Basics Advanced Blemish Spot Treatment with 2% Salicylic Acid Acne Medication, 0.75 Fluid Ounces, 1-Pack

5

Neutrogena On-The-Spot Acne Spot Treatment Cream with 2.5% Benzoyl Peroxide, Gentle Face Blemish Medicine for Acne-Prone Skin, Vanishing Formula, Clinically Proven Day-1 Results, 0.75-Ounce Tube

6

Neutrogena On-The-Spot Acne Spot Treatment Cream with 2.5% Benzoyl Peroxide, Gentle Face Blemish Medicine for Acne-Prone Skin, Vanishing Formula, Clinically Proven Day-1 Results, 0.75-Ounce Tube

7

The Ordinary Salicylic Acid 2% Solution, Acne-Fighting Serum for Blemish-Prone Skin, 1 Fl Oz

8

The Ordinary Salicylic Acid 2% Solution, Acne-Fighting Serum for Blemish-Prone Skin, 1 Fl Oz

9

AcneFree Terminator 10 Acne Spot Treatment with Benzoyl Peroxide 10% Maximum Strength Acne Cream Treatment, 1 Ounce - Pack Of 1

9.7

8.4

8.0

10

AcneFree Terminator 10 Acne Spot Treatment with Benzoyl Peroxide 10% Maximum Strength Acne Cream Treatment, 1 Ounce - Pack Of 1

9.7

8.4

8.0

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