10 Best blemish spot treatments of 2025

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Best Choice

1

Mario Badescu
Mario Badescu Drying Lotion for All Skin Types| Blemish Spot Treatment with Salicylic Acid and Sulfur | Dries Surface Blemishes | 1 Fl Oz
Main highlights

Key Features and Benefits
Fast-acting acne treatment, reduces blemish size overnight, suitable for occasional use.

Ideal Use Cases
Best for emergency acne treatment, spot application for quick results.

Praised Feature
Highly effective in reducing blemish size and duration.
9.8

Exceptional

Our Rating

8.0
For Gentle skin

8.0
Aroma

8.0
Moisturizing
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Value for Money

2

Mighty Patch
Mighty Patch™ Original patch from Hero Cosmetics – The #1 Hydrocolloid Acne Pimple Patch for Shrinking Zits and Whiteheads in 1 use; Nighttime Spot Stickers for Face and Skin (36 Count)
Main highlights

Overnight Pimple Treatment
Mighty Patch Original uses hydrocolloid to visibly improve pimples overnight, reducing redness and size.

Best for Night Use
Ideal for overnight use, these patches stay on securely while you sleep.

Customer Praised Adhesion
Customers love the strong adhesion that keeps the patch in place all night.
9.5

Excellent

Our Rating

9.5
Simple to use

9.5
Simple to take off

9.5
Attachment
3

Neutrogena
Neutrogena On-The-Spot Acne Spot Treatment Cream with 2.5% Benzoyl Peroxide, Gentle Face Blemish Medicine for Acne-Prone Skin, Vanishing Formula, Clinically Proven Day-1 Results, 0.75-Ounce Tube

31% Off
Main highlights

Effective Acne Treatment with Benzoyl Peroxide
.75-ounce tube with 2.5% benzoyl peroxide fights acne gently.

Ideal for Daily Use on Acne-Prone Skin
Use up to three times daily without over-drying.

Praised for Quick and Visible Results
Customers appreciate its effectiveness and quick results.
Key specs
- Skin Type:All skin types
- Formulation:Cream
- Effects:Fights acne
- Niacinamide:N/A
- Hyaluronic Acid:N/A
9.3

Excellent

Our Rating
4

Amazon Basics
Amazon Basics Advanced Blemish Spot Treatment with 2% Salicylic Acid Acne Medication, 0.75 Fluid Ounces, 1-Pack
Main highlights

Advanced Acne Treatment
Formulated with 2% Salicylic Acid to effectively treat acne.

Targeted Spot Application
Ideal for applying on specific blemishes one to three times daily.

High Volume Tube
Praised for containing a generous amount of product.
Key specs
- Skin Benefits:Acne treatment
- Formulation:Spot treatment
- Application Frequency:One to three times daily
- Active Ingredient:2% Salicylic Acid
- Skin Type:N/A
9.1

Excellent

Our Rating
5

AcneFree
AcneFree Terminator 10 Acne Spot Treatment with Benzoyl Peroxide 10% Maximum Strength Acne Cream Treatment, 1 Ounce - Pack Of 1

35% Off
Main highlights

Maximum Strength Benzoyl Peroxide
Contains 10% benzoyl peroxide for effective acne treatment and redness control.

Ideal for Spot Treatment
Best used for treating individual pimples and mild recurring acne.

Convenient Flip-Cap Design
Praised for its easy-to-use flip-cap that prevents loss and simplifies application.
Key specs
- Skin Benefits:Redness Control
- Formulation:Cream
- Application Frequency:N/A
- Active Ingredient:N/A
- Skin Type:N/A
8.9

Very Good

Our Rating

9.7
quality of ingredients

8.4
worth the money

8.0
Sheerness
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6

The Ordinary
The Ordinary Salicylic Acid 2% Solution, Acne-Fighting Serum for Blemish-Prone Skin, 1 Fl Oz
Main highlights

Blemish-Reduction Formula
The Ordinary Salicylic Acid 2% Solution targets acne and blemishes effectively.

Ideal for Oily Skin
Best used for oily and blemish-prone skin types.

Customer Praised Clarity
Users frequently commend its ability to clear skin blemishes.
8.6

Very Good

Our Rating
7

Neutrogena
Neutrogena Rapid Clear Stubborn Acne Spot Treatment Gel, Maximum Strength 10% Benzoyl Peroxide Treatment Medication for Acne Prone Skin, Pimple Cream Reduces Size & Redness in 2 Hours, 1 oz

27% Off
Main highlights

Maximum Strength Benzoyl Peroxide
Contains 10% benzoyl peroxide for rapid acne reduction.

Ideal for Stubborn Acne
Perfect for treating stubborn acne on acne-prone skin.

Quick and Effective Results
Praised for reducing acne size and redness within hours.
8.5

Good

Our Rating

8.7
Aroma

8.4
Fashion

8.2
worth the money
8

e.l.f.
e.l.f. SKIN Blemish Breakthrough Acne Fighting Spot Gel, Roll-on For Treating Blemishes, Made With Salicylic Acid, Vegan & Cruelty-Free
Main highlights

Acne Fighting Formula
Infused with Salicylic Acid, treats and prevents blemishes.

Ideal for Oily Skin
Perfect for acne-prone, oily skin types needing quick relief.

Cooling Sensation
Praised for its soothing, cool feeling and redness reduction.
Key specs
- Function:Acne treatment
- Skin Type:Oily and acne-prone
- Usage:Up to three times daily
- Size:0.63 ounces
- Ingredients:Salicylic Acid, Aloe, Witch Hazel
8.3

Good

Our Rating
9

Bye Bye Blemish

Bye Bye Blemish Acne Drying Lotion, Reduce Pimples Overnight 1oz, 1-Pack
8.2

Good

Our Rating
10

Clean & Clear
Clean & Clear Persa-Gel 10 Oil-Free Acne Spot Treatment with Maximum Strength 10% Benzoyl Peroxide, Topical Pimple Cream & Gel Medication for Face, Fragrance-Free, 1 fl. oz, 4 Pack

25% Off
Main highlights

Maximum Strength Formula
Contains 10% benzoyl peroxide for effective acne treatment.

Ideal for Spot Treatment
Perfect for inflamed acne bumps and quick results.

Highly Praised for Quick Results
Users report visible reduction in acne overnight.
8.1

Good

Our Rating

10 Best blemish spot treatments of 2025

1

Mario Badescu Drying Lotion for All Skin Types| Blemish Spot Treatment with Salicylic Acid and Sulfur | Dries Surface Blemishes | 1 Fl Oz

8.0

8.0

8.0

How do we rank?

How do we rank?

Analyzing top stores

2

Mighty Patch™ Original patch from Hero Cosmetics – The #1 Hydrocolloid Acne Pimple Patch for Shrinking Zits and Whiteheads in 1 use; Nighttime Spot Stickers for Face and Skin (36 Count)

9.5

9.5

9.5

3

Neutrogena On-The-Spot Acne Spot Treatment Cream with 2.5% Benzoyl Peroxide, Gentle Face Blemish Medicine for Acne-Prone Skin, Vanishing Formula, Clinically Proven Day-1 Results, 0.75-Ounce Tube

4

Amazon Basics Advanced Blemish Spot Treatment with 2% Salicylic Acid Acne Medication, 0.75 Fluid Ounces, 1-Pack

5

AcneFree Terminator 10 Acne Spot Treatment with Benzoyl Peroxide 10% Maximum Strength Acne Cream Treatment, 1 Ounce - Pack Of 1

9.7

8.4

8.0

6

The Ordinary Salicylic Acid 2% Solution, Acne-Fighting Serum for Blemish-Prone Skin, 1 Fl Oz

7

Neutrogena Rapid Clear Stubborn Acne Spot Treatment Gel, Maximum Strength 10% Benzoyl Peroxide Treatment Medication for Acne Prone Skin, Pimple Cream Reduces Size & Redness in 2 Hours, 1 oz

8.7

8.4

8.2

8

e.l.f. SKIN Blemish Breakthrough Acne Fighting Spot Gel, Roll-on For Treating Blemishes, Made With Salicylic Acid, Vegan & Cruelty-Free

9

Bye Bye Blemish Acne Drying Lotion, Reduce Pimples Overnight 1oz, 1-Pack

10

Clean & Clear Persa-Gel 10 Oil-Free Acne Spot Treatment with Maximum Strength 10% Benzoyl Peroxide, Topical Pimple Cream & Gel Medication for Face, Fragrance-Free, 1 fl. oz, 4 Pack

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