10 Best preservative free moisturizing eye drops of 2025

Save up to 33% off

Best Choice

1

Systane
Systane COMPLETE PF Multi-Dose Preservative Free Dry Eye Drops 0.34 Fl Oz, 2 count (pack of 1) (Packaging may vary)
Main highlights

Fast Acting Hydration
Nano droplets provide quick and effective moisture for sensitive eyes.

Ideal for Post-Lasik
Recommended for use before and after Lasik surgery for optimal recovery.

Improved Bottle Design
New squeeze bottle retains shape and reduces waste, praised by users.
9.9

Exceptional

Our Rating

9.1
Long life

9.1
Moisturizing

8.2
worth the money
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Value for Money

2

Systane

Systane PRO PF Multi-dose Preservative-Free Lubricant Eye Drops 2 Count

26% Off
9.8

Exceptional

Our Rating
3

Systane
Systane Hydration Multi-Dose Preservative-Free Eye Drops Dry Eye Relief Twin Pack (2x10ml)

33% Off
Main highlights

Fast Hydration and Long-Lasting Relief
Provides quick hydration and sustained relief for dry eyes.

Ideal for Contact Lens Wearers
Safe for use with all contact lenses, perfect for daily wear.

User-Friendly Bottle Design
Customers appreciate the easy-to-use bottle, despite some dispensing issues.
Key specs
- Formula:Contains hyaluronate
- Usage:Safe with contact lenses
- Preservatives:Preservative free
- Hydration:Advanced hydration
- Content:1.45 ounces
9.7

Exceptional

Our Rating

9.3
Moisturizing

8.7
worth the money

8.0
Simple to use
4

Refresh

Refresh Tears PF Preservative-Free Artificial Tears Lubricant Eye Drops, 0.33 fl oz (10 mL)
9.4

Excellent

Our Rating
5

Refresh
Refresh Plus Lubricant Eye Drops, Preservative-Free, 0.01 Fl Oz Single-Use Containers, 50 Count, Packaging May Vary

27% Off
Main highlights

Preservative-Free Formula
Original strength, preservative-free formula that mimics natural tears.

Ideal for Post-Surgery and Dry Eyes
Recommended for use after LASIK and for relieving mild dryness.

Highly Praised Convenience
Single-use vials praised for preventing contamination and ensuring hygiene.
Key specs
- Preservative Free:Yes
- Use Case:After LASIK or surgeries
- Relief Duration:Instantly moisturizes and lubricates
- Eye Comfort:Great for sensitive eyes
- Moisturizing Formula:Original strength, preservative-free
9.3

Excellent

Our Rating

9.5
Simple to use

9.5
Moisturizing

9.3
Comfort
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6

Biotrue

Biotrue Hydration Boost Eye Drops Multi-Dose for Irritated and Dry Eyes from Bausch + Lomb, Preservative Free, pH Balanced, Naturally Inspired 0.33 FL OZ (10 mL)

11% Off
9.0

Excellent

Our Rating
7

Refresh
Refresh Optive MEGA-3 Lubricant Eye Drops Preservative-Free Artificial Tears, 0.01 fl oz (0.4 mL), 30 Single-Use Containers

26% Off
Main highlights

Fast-Acting Relief
Rapidly comforts dry, irritated eyes with a triple-action formula.

Ideal for On-the-Go
Single-use vials are convenient for travel and frequent use.

Praised for Immediate Relief
Customers love the quick relief from dryness and irritation.
8.9

Very Good

Our Rating

9.9
Simple to use

9.3
Moisturizing

8.9
Long life
8

Systane
Systane Ultra Multi-Dose Preservative-Free Eye Drops Twin Pack (2x10ml)

29% Off
Main highlights

Preservative-Free Hydration
Fast-acting hydration with a preservative-free formula for sensitive eyes, providing lasting dry eye relief.

Ideal for Screen Users
Perfect for users experiencing dry eyes from prolonged screen time or contact lens wear.

Highly Effective Relief
Customers praise its effectiveness in soothing dry and irritated eyes despite the bottle design.
Key specs
- Preservative Free:Preservative-Free
- Use Case:dry eye symptom relief
- Relief Duration:lasting dry eye relief
- Eye Comfort:for sensitive eyes
- Moisturizing Formula:Moisture rich formula
8.8

Very Good

Our Rating
9

TheraTears
TheraTears Dry Eye Therapy Lubricating Eye Drops for Dry Eyes, Preservative Free eye drops, 30 Single-Use Vials

15% Off
Main highlights

Immediate Long-Lasting Relief
TheraTears provides immediate, long-lasting relief from dry eye symptoms with its unique formula.

Ideal After LASIK
Perfect for post-LASIK care, offering gentle hydration and soothing relief.

Praised Reusability
Customers love the reusability of vials, minimizing waste and maximizing value.
Key specs
- Formula:Lubricant eye drops
- Usage:Immediate relief
- Preservatives:Preservative free
- Hydration:Silky hydration
- Content:30 vials
8.6

Very Good

Our Rating

9.9
Simple to use

9.1
Moisturizing

8.9
Comfort
10

iVIZIA
iVIZIA Lubricant Eye Gel for Severe and Nighttime Dry Eye Relief, Preservative-Free, Moisturizing, 30 Sterile Single-Use Vials Packaging May Vary
Main highlights

Thicker Formula for Overnight Use
The gel provides more lubrication and moisture than daytime formulas, ideal for relieving severe dry eye symptoms, especially overnight.

Ideal for Severe Dry Eye or Nighttime Use
iVIZIA Lubricant Eye Gel is perfect for individuals with severe dry eye symptoms or those needing extra moisture during nighttime.

Long-Lasting Hydration
Customers frequently praise the product for its ability to provide lasting relief and hydration, reducing the need for frequent reapplication.
Key specs
- Formula:Thicker gel
- Usage:Relieve severe dry eye
- Preservatives:Preservative-free
- Hydration:Hyaluronic Acid, Trehalose
- Content:Sterile single-use vials
8.4

Good

Our Rating

9.7
Moisturizing

8.7
worth the money

8.0
Simple to use

10 Best preservative free moisturizing eye drops of 2025

1

Systane COMPLETE PF Multi-Dose Preservative Free Dry Eye Drops 0.34 Fl Oz, 2 count (pack of 1) (Packaging may vary)

9.1

9.1

8.2

How do we rank?

How do we rank?

Analyzing top stores

2

Systane PRO PF Multi-dose Preservative-Free Lubricant Eye Drops 2 Count

3

Systane Hydration Multi-Dose Preservative-Free Eye Drops Dry Eye Relief Twin Pack (2x10ml)

9.3

8.7

8.0

4

Refresh Tears PF Preservative-Free Artificial Tears Lubricant Eye Drops, 0.33 fl oz (10 mL)

5

Refresh Plus Lubricant Eye Drops, Preservative-Free, 0.01 Fl Oz Single-Use Containers, 50 Count, Packaging May Vary

9.5

9.5

9.3

6

Biotrue Hydration Boost Eye Drops Multi-Dose for Irritated and Dry Eyes from Bausch + Lomb, Preservative Free, pH Balanced, Naturally Inspired 0.33 FL OZ (10 mL)

7

Refresh Optive MEGA-3 Lubricant Eye Drops Preservative-Free Artificial Tears, 0.01 fl oz (0.4 mL), 30 Single-Use Containers

9.9

9.3

8.9

8

Systane Ultra Multi-Dose Preservative-Free Eye Drops Twin Pack (2x10ml)

9

TheraTears Dry Eye Therapy Lubricating Eye Drops for Dry Eyes, Preservative Free eye drops, 30 Single-Use Vials

9.9

9.1

8.9

10

iVIZIA Lubricant Eye Gel for Severe and Nighttime Dry Eye Relief, Preservative-Free, Moisturizing, 30 Sterile Single-Use Vials Packaging May Vary

9.7

8.7

8.0

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