10 Best preservative free eye drops of 2025

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1

Generic

Forte Eye Drops Preservative Free Lubricating Eye Drops for Treatment of Severe and Persistant Dry Eyes - 10ml X 3 Pack
9.8

Exceptional

Our Rating
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Value for Money

2

Refresh
Refresh Plus Lubricant Eye Drops For Dry Eyes, Preservative-Free,Value Size, 0.01 Fl Oz Single-Use Containers, 70 Count

29% Off
Main highlights

Preservative-Free Comfort
Original strength, preservative-free formula ideal for sensitive eyes.

Post-Surgery Relief
Effective for dryness relief after LASIK or cataract surgery.

Single-Use Convenience
Praised for sterile, single-use vials reducing contamination risk.
Key specs
- Preservative Free:Yes
- Use Case:After LASIK or surgeries
- Eye Comfort:Great for sensitive eyes
- Moisturizing Formula:Preservative-free formula
- Relief Duration:Instantly moisturizes
9.6

Exceptional

Our Rating

9.9
Simple to use

9.3
worth the money
3

Systane
Systane Ultra Multi-Dose Preservative-Free Eye Drops Twin Pack (2x10ml)

31% Off
Main highlights

Preservative-Free Hydration
Fast-acting hydration with a preservative-free formula for sensitive eyes, providing lasting dry eye relief.

Ideal for Screen Users
Perfect for users experiencing dry eyes from prolonged screen time or contact lens wear.

Highly Effective Relief
Customers praise its effectiveness in soothing dry and irritated eyes despite the bottle design.
Key specs
- Preservative Free:Preservative-Free
- Use Case:dry eye symptom relief
- Eye Comfort:for sensitive eyes
- Moisturizing Formula:Moisture rich formula
- Relief Duration:lasting dry eye relief
9.5

Excellent

Our Rating
4

Systane
Systane COMPLETE PF Multi-Dose Preservative Free Dry Eye Drops 0.34 Fl Oz, 2 count (pack of 1) (Packaging may vary)

40% Off
Main highlights

Fast Acting Hydration
Nano droplets provide quick and effective moisture for sensitive eyes.

Ideal for Post-Lasik
Recommended for use before and after Lasik surgery for optimal recovery.

Improved Bottle Design
New squeeze bottle retains shape and reduces waste, praised by users.
9.4

Excellent

Our Rating

9.1
Long life

9.1
Moisturizing

8.2
worth the money
5

Refresh
Refresh Plus Lubricant Eye Drops For Dry Eyes, Preservative-Free, 0.01 Fl Oz Single-Use Containers, 50 Count
Main highlights

Preservative-Free Formula
Original strength, preservative-free formula that mimics natural tears.

Ideal for Post-Surgery and Dry Eyes
Recommended for use after LASIK and for relieving mild dryness.

Highly Praised Convenience
Single-use vials praised for preventing contamination and ensuring hygiene.
Key specs
- Preservative Free:Yes
- Use Case:After LASIK or surgeries
- Eye Comfort:Great for sensitive eyes
- Moisturizing Formula:Original strength, preservative-free
- Relief Duration:Instantly moisturizes and lubricates
9.2

Excellent

Our Rating

9.5
Simple to use

9.5
Moisturizing

9.3
Comfort
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6

TheraTears
TheraTears Dry Eye Therapy Lubricating Eye Drops for Dry Eyes, Preservative Free eye drops, 30 Single-Use Vials

15% Off
Main highlights

Immediate Long-Lasting Relief
TheraTears provides immediate, long-lasting relief from dry eye symptoms with its unique formula.

Ideal After LASIK
Perfect for post-LASIK care, offering gentle hydration and soothing relief.

Praised Reusability
Customers love the reusability of vials, minimizing waste and maximizing value.
Key specs
- Formula:Lubricant eye drops
- Usage:Immediate relief
- Preservatives:Preservative free
- Hydration:Silky hydration
- Content:30 vials
9.0

Excellent

Our Rating

9.9
Simple to use

9.1
Moisturizing

8.9
Comfort
7

Refresh

Refresh Tears PF Preservative-Free Artificial Tears Lubricant Eye Drops, 0.33 fl oz (10 mL)
8.7

Very Good

Our Rating
8

Refresh
Refresh RELIEVA Preservative-Free Tears Lubricant Eye Drops, 0.33 fl oz (10 mL)

34% Off
Main highlights

Key Features
Preservative-free formula with Hydrocell technology for hydration, designed for dry, irritated eyes. Patented sterile bottle. #1 in preservative-free artificial tears.

Ideal Use Cases
Perfect for sensitive eyes, post-LASIK surgery care, and those seeking relief from dryness and discomfort without preservatives.

Customer Reviews Highlight
Most praised for providing immediate relief and comfort to sensitive and dry eyes, with the sterile bottle design receiving significant appreciation.
Key specs
- Preservative Free:Yes
- Use Case:Dry, irritated eyes
- Eye Comfort:Relieves discomfort
- Moisturizing Formula:Hydrocell technology
- Relief Duration:N/A
8.6

Very Good

Our Rating

8.0
worth the money

8.0
dispense easily

8.0
Simple to use
9

Biotrue
Biotrue Hydration Boost, Preservative-Free Eye Drops for Dry Eyes, Instantly Moisturizes, Clears and Rehydrates, Contact Lens Friendly, Refresh & Relieve Eye Irritation, 0.33 FL Oz (Pack of 2)
Main highlights

Key Features and Benefits
Features HA Hyaluronan, antioxidants, and electrolytes for instant moisture. Preservative-free and pH balanced, suitable for contact lens wearers.

Ideal Use Cases
Perfect for relieving dry, irritated eyes caused by extensive screen use, environmental factors, and contact lens wear.

Customer Reviews Highlight
Most praised for providing immediate relief and comfort to dry eyes, with users appreciating its contact lens compatibility.
8.5

Good

Our Rating

9.9
Comfort

9.3
worth the money

9.3
Moisturizing
10

Refresh
Refresh Optive Mega-3 Lubricant Eye Drops For Dry Eyes, Preservative-Free, 0.01 Fl Oz Single-Use Containers, 30 Count

18% Off
Main highlights

Fast-Acting Relief
Rapidly comforts dry, irritated eyes with a triple-action formula.

Ideal for On-the-Go
Single-use vials are convenient for travel and frequent use.

Praised for Immediate Relief
Customers love the quick relief from dryness and irritation.
8.3

Good

Our Rating

9.9
Simple to use

9.3
Moisturizing

8.9
Long life

10 Best preservative free eye drops of 2025

1

Forte Eye Drops Preservative Free Lubricating Eye Drops for Treatment of Severe and Persistant Dry Eyes - 10ml X 3 Pack

How do we rank?

How do we rank?

Analyzing top stores

2

Refresh Plus Lubricant Eye Drops For Dry Eyes, Preservative-Free,Value Size, 0.01 Fl Oz Single-Use Containers, 70 Count

9.9

9.3

3

Systane Ultra Multi-Dose Preservative-Free Eye Drops Twin Pack (2x10ml)

4

Systane COMPLETE PF Multi-Dose Preservative Free Dry Eye Drops 0.34 Fl Oz, 2 count (pack of 1) (Packaging may vary)

9.1

9.1

8.2

5

Refresh Plus Lubricant Eye Drops For Dry Eyes, Preservative-Free, 0.01 Fl Oz Single-Use Containers, 50 Count

9.5

9.5

9.3

6

TheraTears Dry Eye Therapy Lubricating Eye Drops for Dry Eyes, Preservative Free eye drops, 30 Single-Use Vials

9.9

9.1

8.9

7

Refresh Tears PF Preservative-Free Artificial Tears Lubricant Eye Drops, 0.33 fl oz (10 mL)

8

Refresh RELIEVA Preservative-Free Tears Lubricant Eye Drops, 0.33 fl oz (10 mL)

8.0

8.0

8.0

9

Biotrue Hydration Boost, Preservative-Free Eye Drops for Dry Eyes, Instantly Moisturizes, Clears and Rehydrates, Contact Lens Friendly, Refresh & Relieve Eye Irritation, 0.33 FL Oz (Pack of 2)

9.9

9.3

9.3

10

Refresh Optive Mega-3 Lubricant Eye Drops For Dry Eyes, Preservative-Free, 0.01 Fl Oz Single-Use Containers, 30 Count

9.9

9.3

8.9

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