September 5, 2025

Advertising Disclosure

10 Best methylfolate supplements of 2025

Save up to 39% off

Best Choice

1

Carlyle
Carlyle L Methylfolate 15mg | 120 Capsules | Value Size | Max Potency | Optimized and Activated | Non-GMO, Gluten Free | Methyl Folate, 5-MTHF | by Opti-Folate

14% Off
Main highlights

High Potency Formula
Delivers 25,000 mcg Folate and 15 mg L-Methylfolate for maximum efficacy.

Ideal for Genetic Conditions
Perfect for individuals with genetic conditions affecting folate metabolism.

Praised for Affordability
Customers appreciate the cost-effectiveness compared to prescription alternatives.
9.7

Exceptional

Our Rating

9.9
simple to consume

9.9
Absorbency

9.5
worth the money
How do we rank?

Powerful technology We scan thousands of products and stores, analyzing reviews to find what matters most to users like you

Careful review Our team ensures quality, value, and fit based on real user feedback

Trusted insights AI and human analysis guide your decisions, reflecting real user priorities
Real users impact

Thousands of users trust our site daily

Based on millions of stores and reviews

Shoppers influence our rankings
Analyzing top stores
Value for Money

2

THORNE
THORNE 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation, and Homocysteine Levels* - 60 Capsules - 5-MTHF 1mg
Main highlights

Supports Cardiovascular and Nerve Health
Thorne 5-MTHF provides active folate for cardiovascular, nerve health, and methylation support.

Ideal for MTHFR Gene Mutation
Perfect for individuals with MTHFR mutation needing enhanced folate absorption.

Improves Focus and Mood
Customers praise its ability to enhance focus, mood, and overall well-being.
9.6

Exceptional

Our Rating

9.9
simple to consume

9.5
Absorbency

9.3
worth the money
3

Triquetra Health
L Methyl Folate 15mg Plus Methyl B12 Cofactor – Organic Berry Flavor, High Potency Liquid Sublingual Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive Forms Vitamin B9 & B12 (1oz)
Main highlights

Key Features and Benefits
Clinically validated 15mg L-Methylfolate in active form for superior absorption, with essential Methyl B12 for methylation and homocysteine breakdown.

Ideal Use Cases
Ideal for supporting brain, mood, energy, cardiovascular health, and nerve function, especially in those with methylation issues who can`t process folic acid.

Customer Reviews Summary
Highly praised for its effective support of mood and energy levels, with the cherry-flavored, sublingual form noted for its ease of use.
Key specs
- Form:Liquid sublingual
- Active Ingredient:L Methyl folate
- Bioavailability:Enhanced sublingual absorption
- Dosage:15mg
- Serving Size:N/A
9.5

Excellent

Our Rating

9.7
simple to consume

9.7
Absorbency

9.5
worth the money
4

NOW Foods
NOW Foods Supplements, Methyl Folate 1,000 mcg, Metabolically Active Folate*, Co-Enzyme B Vitamin, 90 Tablets

38% Off
Main highlights

Superior Bioavailability and Potency
Methylfolate, a biologically active form, enhances cell function and DNA synthesis.

Ideal for MTHFR Gene Mutation
Perfect for those needing methylfolate supplementation due to genetic mutations.

Easy to Swallow Tablets
Customers appreciate the ease of swallowing despite the tablet size.
9.2

Excellent

Our Rating

9.9
simple to consume

9.9
Absorbency

9.7
worth the money
5

Nutricost
Nutricost Methylfolate 1000mcg, 120 Vegetarian Capsules - Gluten Free, Non-GMO

18% Off
Main highlights

High Potency Formula
Contains 1,000mcg Methyl Folate per serving; 120 servings total.

Ideal for Energy Boost
Perfect for individuals seeking enhanced energy and mood improvement.

Praised for Value
Customers frequently commend its affordability and noticeable benefits.
9.1

Excellent

Our Rating

9.5
simple to consume

9.5
Flavor

9.1
Absorbency
See Today’s Deals & Prices
6

Triquetra Health
Organic Methyl Folate 1000 mcg + Methyl B12 Cofactor (300 Servings) – Metabolically Active 5-MTHF Form, Organic Berry Flavor, Liquid Sublingual Form – Mood, Cognition, Methylation, Pregnancy (1oz)
Main highlights

Biologically Active Folate
L-Methylfolate in 1000 mcg dose for immediate absorption and no processing.

Ideal for Methylation Support
Supports healthy methylation, brain, mood, energy, and pregnancy needs.

Easy Sublingual Use
Praised for its pleasant taste and straightforward sublingual application.
Key specs
- Form:Liquid sublingual
- Active Ingredient:L-Methylfolate
- Bioavailability:Enhanced sublingual absorption
- Dosage:1 mg or 1000 mcg
- Serving Size:N/A
8.9

Very Good

Our Rating
7

Life Extension
Life Extension Optimized Folate – L-methylfolate – Heart & Brain Support, Healthy Homocysteine Levels – Non-GMO, Gluten-Free, Vegetarian – 1700 mcg DFE, 100 Vegetarian Tablets
Main highlights

Optimal Cognitive Support
This folate supplement supports brain health and optimal cognitive function as you age.

Ideal for MTHFR Mutation
Best for individuals with MTHFR mutation needing L-methylfolate supplementation.

Highly Effective Methylfolate
Praised for its high-quality, effective L-methylfolate form over folic acid.
Key specs
- Form:Supplement
- Active Ingredient:5-MTHF
- Bioavailability:Metabolically active form
- Dosage:1700 mcg
- Serving Size:N/A
8.8

Very Good

Our Rating

9.3
simple to consume

9.3
worth the money

9.1
Flavor
8

Jarrow Formulas
Jarrow Formulas Methyl B-12 1000 MCG and Methyl Folate 400 MCG, Extra Strength, Cellular Energy Metabolism and Cardiovascular Health Formula(1) With P-5-P, 100 Chewable Tablets, Up to a 100 Day Supply

39% Off
Main highlights

Key Features
Combines Methyl B12, Methyl Folate, and P-5-P for enhanced energy metabolism, cardiovascular support, and neurotransmitter synthesis in lemon-flavored chewables.

Ideal Use Cases
Perfect for adults seeking to boost energy, support heart health, and improve neurological function with a daily, easy-to-take supplement.

Customer Reviews Highlight
Most praised for its noticeable boost in energy levels and overall mood improvement, according to consistent user feedback.
Key specs
- Target:Cellular energy metabolism
- Form:Chewable Tablets
- Quantity:100 count
- Dosage:1000 mcg
- Flavor:Lemon
8.7

Very Good

Our Rating

9.3
simple to consume

9.3
worth the money

9.3
Absorbency
9

Jarrow Formulas
Jarrow Formulas Extra Strength Methyl Folate 400 mcg, Dietary Supplement for Cardiovascular and Neurologic Health Support, 60 Veggie Capsules, 60 Day Supply

33% Off
Main highlights

Supports Cardiovascular and Neurologic Health
Contains 400 mcg of Methyl Folate 5-MTHF for heart and brain support.

Ideal for MTHFR Gene Mutation
Perfect for individuals who cannot convert synthetic folic acid.

High Bioavailability and Quality
Praised for its bioavailable form, Quatrefolic methyl folate.
Key specs
- Form:Veggie Capsules
- Active Ingredient:Methyl Folate 5-MTHF
- Bioavailability:Biologically active
- Dosage:400 mcg
- Serving Size:One capsule
8.6

Very Good

Our Rating

9.9
simple to consume

9.7
quality of ingredients

9.7
Absorbency
10

Horbäach
Horbäach Methyl Folate Supplement | 1000 mcg | 200 Capsules | 5-MTHF | Folic Acid for Women & Men | Non-GMO, Gluten Free Methylfolate

14% Off
Main highlights

Bioavailable Folic Acid
Methyl Folate provides a more bioavailable form of folic acid, enhancing absorption and efficacy.

Daily Wellness Support
Ideal for supporting daily wellness, particularly for individuals with specific health needs.

Customer Satisfaction
Praised for its effectiveness in improving health markers and overall well-being.
Key specs
- Form:Quick-Release capsules
- Active Ingredient:Methyl Folate
- Bioavailability:More bioavailable
- Dosage:1000 mcg
- Serving Size:N/A
8.5

Good

Our Rating

9.9
simple to consume

9.9
quality of ingredients

9.7
worth the money

10 Best methylfolate supplements of 2025

1

Carlyle L Methylfolate 15mg | 120 Capsules | Value Size | Max Potency | Optimized and Activated | Non-GMO, Gluten Free | Methyl Folate, 5-MTHF | by Opti-Folate

9.9

9.9

9.5

How do we rank?

How do we rank?

Analyzing top stores

2

THORNE 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation, and Homocysteine Levels* - 60 Capsules - 5-MTHF 1mg

9.9

9.5

9.3

3

L Methyl Folate 15mg Plus Methyl B12 Cofactor – Organic Berry Flavor, High Potency Liquid Sublingual Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive Forms Vitamin B9 & B12 (1oz)

9.7

9.7

9.5

4

NOW Foods Supplements, Methyl Folate 1,000 mcg, Metabolically Active Folate*, Co-Enzyme B Vitamin, 90 Tablets

9.9

9.9

9.7

5

Nutricost Methylfolate 1000mcg, 120 Vegetarian Capsules - Gluten Free, Non-GMO

9.5

9.5

9.1

6

Organic Methyl Folate 1000 mcg + Methyl B12 Cofactor (300 Servings) – Metabolically Active 5-MTHF Form, Organic Berry Flavor, Liquid Sublingual Form – Mood, Cognition, Methylation, Pregnancy (1oz)

7

Life Extension Optimized Folate – L-methylfolate – Heart & Brain Support, Healthy Homocysteine Levels – Non-GMO, Gluten-Free, Vegetarian – 1700 mcg DFE, 100 Vegetarian Tablets

9.3

9.3

9.1

8

Jarrow Formulas Methyl B-12 1000 MCG and Methyl Folate 400 MCG, Extra Strength, Cellular Energy Metabolism and Cardiovascular Health Formula(1) With P-5-P, 100 Chewable Tablets, Up to a 100 Day Supply

9.3

9.3

9.3

9

Jarrow Formulas Extra Strength Methyl Folate 400 mcg, Dietary Supplement for Cardiovascular and Neurologic Health Support, 60 Veggie Capsules, 60 Day Supply

9.9

9.7

9.7

10

Horbäach Methyl Folate Supplement | 1000 mcg | 200 Capsules | 5-MTHF | Folic Acid for Women & Men | Non-GMO, Gluten Free Methylfolate

9.9

9.9

9.7

Sign up and get exclusive special deals