10 Best nighttime eye ointments of 2025

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Best Choice

1

Systane
Systane Lub Eye Nightime Ointment 3.5g (6 Pack) 0.12 Ounce(Packaging May Vary)
Main highlights

Effective for Severe Dry Eyes
Contains 94% White Petrolatum and 3% Mineral Oil, providing long-lasting moisture and relief for extremely dry eyes. Ideal for nighttime use.

Ideal for Post-Eye Surgery Care
Perfect for individuals recovering from eye surgery or those with severe dry eyes. Provides overnight protection and moisture, ensuring comfort and healing.

Highly Praised for Long-Lasting Comfort
Customers appreciate the thick consistency and effectiveness, noting significant relief from dry eyes and improved comfort throughout the night.
9.8

Exceptional

Our Rating

9.5
Moisturizing

9.3
Simple to use

8.7
worth the money
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Value for Money

2

Retaine
Retaine PM Nighttime Lubricant Eye Ointment 5g (2 Pack)
Main highlights

Effective Night Time Moisturizer
This product is praised for being the best night time moisturizer, effectively keeping the eyes from being dry and providing good value for money.

Ideal for Prosthetic Eye Lubrication
Many customers find this product meets their needs for lubricating prosthetic eyes, performing as well as or better than other products.

Commonly Praised for Effectiveness
Customers consistently highlight the product's effectiveness in treating dry eyes, with many noting its superior performance and value.
9.7

Exceptional

Our Rating

9.3
Moisturizing

8.9
quality of ingredients

8.7
worth the money
3

Systane
Systane Nighttime Lubricant Eye Ointment 3.5g Tube
Main highlights

Long-Lasting Protection
Forms a long-lasting, protective layer on eyes while you sleep, soothing and protecting against dryness and irritation.

Ideal for Nighttime Use
Best used for nighttime relief of dry eye symptoms, providing comfort and protection as you rest.

Soothing Effect
Most praised for its soothing effect, alleviating discomfort from dry eyes effectively.
Key specs
- Formula:Preservative-free
- Usage:Nighttime
- Preservatives:None
- Hydration:Soothes and protects
- Dimensions:6 x 5 x 4 inches
9.5

Excellent

Our Rating
4

Soothe
Soothe Lubricant Eye Ointment by Bausch & Lomb for Dry Eye Relief, Moisturizing Nighttime Therapy Suitable for Sensitive Eyes, Preservative Free, 3.5 g
Main highlights

Key Features and Benefits
Moisturizes and refreshes severe dry eyes overnight with a soothing formula, containing two lubricants for long-lasting relief and comfort.

Ideal Use Cases
Perfect for individuals suffering from severe dry eyes, especially effective overnight to prevent irritation and provide relief from dryness.

Customer Reviews Highlight
Most reviews praise its effectiveness in providing significant relief from severe dryness, noting its ease of use and overnight comfort.
9.2

Excellent

Our Rating

8.2
worth the money

8.0
Simple to use
5

Genteal
Genteal Tears Night-Time Ointment 3.5g Clear 0.12 Fl Oz
Main highlights

Severe Dry Eye Symptom Relief
Provides long-lasting nighttime relief, moisturizes and lubricates eyes, and protects against further eye irritation.

Nighttime Use for Maximum Effectiveness
Ideal for severe dry eyes, Bell's Palsy, Sjogren syndrome, and post-eye surgery care. Apply before bed for best results.

Thick and Soothing Formula
Praised for its thick, soothing consistency that provides overnight comfort and prevents eye irritation and dryness.
9.1

Excellent

Our Rating

9.9
Moisturizing

9.3
worth the money

8.0
Simple to use
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6

Systane

Systane Nighttime Lubricant Eye Ointment 3.50 g , 0.12 Oz (Pack of 3)

20% Off
9.0

Excellent

Our Rating
7

Soothe
Soothe Lubricant Eye Ointment by Bausch & Lomb for Dry Eye Relief, Moisturizing Nighttime Therapy Suitable for Sensitive Eyes, Preservative Free, 1.8 Oz (Pack of 2)
Main highlights

Overnight Moisturizing Relief
Soothe Lubricant Eye Ointment offers long-lasting relief for severe dry eyes overnight.

Best for Nighttime Use
Perfect for moisturizing and refreshing dry eyes while you sleep.

Highly Praised Comfort
Customers love the soothing comfort it provides for sensitive eyes.
Key specs
- Active Ingredients:Two lubricants
- Preservative Free:Yes
- Use Case:Dry eyes at night
- Relief Duration:Overnight
- Eye Comfort:Long-lasting relief
8.9

Very Good

Our Rating
8

Optase
Optase HYLO Night Eye Ointment - Preservative Free Lubricant & Nighttime Eye Ointment for Blepharitis and Stye - .18 oz

15% Off
Main highlights

Preservative Free Night Relief
OPTASE Hylo Night Ointment provides comfortable lubrication for dry eye relief, free from preservatives.

Ideal for Nighttime Use
Designed for overnight application to protect and lubricate eyes while sleeping.

Effective Dry Eye Relief
Customers praise its effectiveness in reducing morning dry-eye symptoms and protecting the cornea.
Key specs
- Formula:White Petrolatum, Lanolin, Light Mineral Oil
- Usage:Apply before bed
- Preservatives:Preservative free
- Hydration:Over 6 hours retention
- Dimensions:3.81 x 1.61 x 0.9 inches
8.7

Very Good

Our Rating

9.7
Moisturizing

9.3
Comfort

8.0
Simple to use
9

MAJOR
MAJOR Lubrifresh P.M. Sterile Nighttime Eye Ointment- Preservative-Free Night Time Eye Ointment - Lubricant Relief for Dry Eyes - 3.5 g (1 Pack)
Main highlights

Effective Relief for Dry Eyes
The Major Lubrifresh P.M. Ointment provides preservative-free relief for irritation and dryness, ensuring comfort throughout the night.

Ideal for Nighttime Use
Perfect for use before bed, offering relief from dryness and irritation while you sleep.

Praised for Gentle Formulation
Customers appreciate the gentle, preservative-free formula that soothes without irritation.
8.5

Good

Our Rating
10

iVIZIA
iVIZIA Lubricant Eye Gel for Severe and Nighttime Dry Eye Relief, Preservative-Free, Moisturizing, 30 Sterile Single-Use Vials Packaging May Vary
Main highlights

Thicker Formula for Overnight Use
The gel provides more lubrication and moisture than daytime formulas, ideal for relieving severe dry eye symptoms, especially overnight.

Ideal for Severe Dry Eye or Nighttime Use
iVIZIA Lubricant Eye Gel is perfect for individuals with severe dry eye symptoms or those needing extra moisture during nighttime.

Long-Lasting Hydration
Customers frequently praise the product for its ability to provide lasting relief and hydration, reducing the need for frequent reapplication.
Key specs
- Formula:Thicker gel
- Usage:Relieve severe dry eye
- Preservatives:Preservative-free
- Hydration:Hyaluronic Acid, Trehalose
- Dimensions:4.76 x 2.95 x 2.24 inches
8.3

Good

Our Rating

9.7
Moisturizing

8.7
worth the money

8.0
Simple to use

10 Best nighttime eye ointments of 2025

1

Systane Lub Eye Nightime Ointment 3.5g (6 Pack) 0.12 Ounce(Packaging May Vary)

9.5

9.3

8.7

How do we rank?

How do we rank?

Analyzing top stores

2

Retaine PM Nighttime Lubricant Eye Ointment 5g (2 Pack)

9.3

8.9

8.7

3

Systane Nighttime Lubricant Eye Ointment 3.5g Tube

4

Soothe Lubricant Eye Ointment by Bausch & Lomb for Dry Eye Relief, Moisturizing Nighttime Therapy Suitable for Sensitive Eyes, Preservative Free, 3.5 g

8.2

8.0

5

Genteal Tears Night-Time Ointment 3.5g Clear 0.12 Fl Oz

9.9

9.3

8.0

6

Systane Nighttime Lubricant Eye Ointment 3.50 g , 0.12 Oz (Pack of 3)

7

Soothe Lubricant Eye Ointment by Bausch & Lomb for Dry Eye Relief, Moisturizing Nighttime Therapy Suitable for Sensitive Eyes, Preservative Free, 1.8 Oz (Pack of 2)

8

Optase HYLO Night Eye Ointment - Preservative Free Lubricant & Nighttime Eye Ointment for Blepharitis and Stye - .18 oz

9.7

9.3

8.0

9

MAJOR Lubrifresh P.M. Sterile Nighttime Eye Ointment- Preservative-Free Night Time Eye Ointment - Lubricant Relief for Dry Eyes - 3.5 g (1 Pack)

10

iVIZIA Lubricant Eye Gel for Severe and Nighttime Dry Eye Relief, Preservative-Free, Moisturizing, 30 Sterile Single-Use Vials Packaging May Vary

9.7

8.7

8.0

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