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8 Best acne spot treatments of 2026

Save up to 28% off
  • Best Choice

    1

    AcneFree Terminator 10 Acne Spot Treatment with Benzoyl Peroxide 10% Maximum Strength Acne Cream Treatment, 1 Ounce - Pack Of 1
    AcneFree
    9.8
    Exceptional

    AcneFree Terminator 10 Acne Spot Treatment with Benzoyl Peroxide 10% Maximum Strength Acne Cream Treatment, 1 Ounce - Pack Of 1

    • is discontinued by manufacturer:No
    • product dimensions:4.57 x 1.45 x 3.74 inches; 1 ounces
    • upc:850004234785
    • asin:B0014VTOAQ
    • department:unisex-adult
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  • Value for Money

    2

    Neutrogena Rapid Clear Stubborn Acne Spot Treatment Gel, 1 oz
    Neutrogena
    9.7
    Exceptional

    Neutrogena Rapid Clear Stubborn Acne Spot Treatment Gel, 1 oz

    28% Off
    • is discontinued by manufacturer:No
    • upc:070501024614
    • asin:B00NR1YVYU
    • item model number:70501024614
    • manufacturer:Kenvue

  • 3

    La Roche-Posay Effaclar Salicylic Acid Acne Treatment for Face 1.35 oz
    La Roche-Posay
    9.6
    Exceptional

    La Roche-Posay Effaclar Salicylic Acid Acne Treatment for Face 1.35 oz

    25% Off

  • 4

    Differin Acne Spot Treatment, Max Strength, 10% Benzoyl Peroxide, 1oz
    Differin
    9.5
    Excellent

    Differin Acne Spot Treatment, Max Strength, 10% Benzoyl Peroxide, 1oz

    16% Off
    • upc:302994611003
    • package dimensions:6.5 x 2.6 x 1.65 inches 1.59 ounces
    • asin:B0D355W5F2
    • item model number:0299.053078
    • manufacturer:Galderma

  • 5

    Neutrogena On-The-Spot Acne Spot Treatment Cream, 0.75 oz
    Neutrogena
    9.2
    Excellent

    Neutrogena On-The-Spot Acne Spot Treatment Cream, 0.75 oz

    17% Off
    • upc:070501017906
    • package dimensions:N/A
    • asin:B00UOLIOC6
    • item model number:2620649002
    • manufacturer:Kenvue
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  • 6

    Clean & Clear Persa-Gel 10 Acne Spot Treatment, 1 fl. oz
    Clean & Clear
    9.1
    Excellent

    Clean & Clear Persa-Gel 10 Acne Spot Treatment, 1 fl. oz

    25% Off
    • is discontinued by manufacturer:N/A
    • upc:381370034056
    • asin:B00KZ22ED4
    • item model number:N/A
    • manufacturer:Johnson & Johnson

  • 7

    Amazon Basics Advanced Acne Spot Treatment with 2% Salicylic Acid Medication, Blemish Treatment, 0.75 Fluid Ounces, 1-Pack
    Amazon Basics
    9.0
    Excellent

    Amazon Basics Advanced Acne Spot Treatment with 2% Salicylic Acid Medication, Blemish Treatment, 0.75 Fluid Ounces, 1-Pack

    19% Off
    • asin:B0BV6HT9PJ
    • product dimensions:1.38 x 1.38 x 5 inches 1.12 ounces
    • date first available:September 6, 2023
    • manufacturer:Amazon.com Services LLC.
    • country of origin:Canada

  • 8

    Amazon Basics 10% Benzoyl Peroxide Acne Treatment Gel, Maximum Strength, 1 Fluid Ounce
    Amazon Basics
    8.9
    Very Good

    Amazon Basics 10% Benzoyl Peroxide Acne Treatment Gel, Maximum Strength, 1 Fluid Ounce

    • is discontinued by manufacturer:N/A
    • upc:N/A
    • asin:B07Z9Y2QHZ
    • item model number:N/A
    • manufacturer:Amazon.com Services LLC.